不同来源的间充质干细胞在肺癌的研究进展
Research Progress of Mesenchymal Stem Cells from Different Sources in Lung Cancer
DOI: 10.12677/acm.2026.1672538, PDF,   
作者: 周 宽, 张婷婷, 李辰浩：延安大学延安医学院，陕西 延安；李 艳, 董 玉*：西安市中心医院呼吸与危重症医学科，陕西 西安
关键词: 间充质干细胞；肺癌；细胞来源；外泌体；肿瘤微环境；Mesenchymal Stem Cells； Lung Cancer； Cell Source； Exosomes； Tumor Microenvironment
摘要: 间充质干细胞(MSCs)因其肿瘤趋向性、免疫调节特性及易于工程化操作的优势，已成为肺癌治疗研究的热点。来源于骨髓、脐带等不同组织的MSCs在生物学特性和抗肿瘤效应方面呈现显著差异。MSCs在肺癌治疗中仍存在促瘤或抑瘤的争议。本文将介绍间充质干细胞对肺癌的可能机制和相关研究进展。
Abstract: Mesenchymal stem cells (MSCs) have become a hot topic in lung cancer treatment research due to their tumor tropism, immunomodulatory properties, and ease of engineering operation. MSCs derived from different tissues such as bone marrow and umbilical cord show significant differences in biological characteristics and anti-tumor effects. There is still controversy over whether MSCs promote or inhibit tumors in the treatment of lung cancer. This article will introduce the possible mechanisms of mesenchymal stem cells in lung cancer and the related research progress.
文章引用：周宽, 张婷婷, 李辰浩, 李艳, 董玉. 不同来源的间充质干细胞在肺癌的研究进展[J]. 临床医学进展, 2026, 16(7): 389-396. https://doi.org/10.12677/acm.2026.1672538

参考文献

[1] Singh, K., Grover, A. and Dhanasekaran, K. (2025) Unveiling the Cancer Epidemic in India: A Glimpse into GLOBOCAN 2022 and Past Patterns. The Lancet Regional Health-Southeast Asia, 34, Article 100546. [Google Scholar] [CrossRef] [PubMed]
[2] Bray, F., Laversanne, M., Sung, H., Ferlay, J., Siegel, R.L., Soerjomataram, I., et al. (2024) Global Cancer Statistics 2022: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 74, 229-263. [Google Scholar] [CrossRef] [PubMed]
[3] Ye, H., Pan, J., Gong, E., Cai, X., Xu, C., Li, Y., et al. (2023) Inhibitory Effect of Immunologically Activated Mesenchymal Stem Cells on Lung Cancer Cell Growth and Metastasis. Cancer Biotherapy and Radiopharmaceuticals, 38, 322-335. [Google Scholar] [CrossRef] [PubMed]
[4] Fregni, G., Quinodoz, M., Möller, E., et al. (2018) Reciprocal Modulation of Mesenchymal Stem Cells and Tumor Cells Promotes Lung Cancer Metastasis. EBioMedicine, 29, 128-145.
[5] 李慧杰, 胡熙文, 齐元富, 等. 代谢重编程对攻毒治法靶向治疗肺癌干细胞的影响[J]. 中国实验方剂学杂志, 2020, 26(8): 75-80.
[6] 刘志远. 富含miR-663a的人脐带间充质干细胞来源外泌体促进巨噬细胞极化治疗糖尿病创面愈合的机制研究[D]: [博士学位论文]. 遵义: 遵义医科大学, 2025.
[7] 马晨, 何亚琴, 马海滨, 等. 人胎盘间充质干细胞外泌体通过稳定RAS系统改善LPS诱导损伤后肺血管内皮纤维化的调控机制研究[J]. 重庆医学, 2026, 55(2): 293-299.
[8] Chen, J., Ding, C., Yang, X., Zhao, J. (2021) BMSCs-Derived Exosomal miR-126-3p Inhibits the Viability of NSCLC Cells by Targeting PTPN9. Journal of Balkan Union of Oncology, 26, 1832-1841.
[9] Ren, J. (2022) Intermittent Hypoxia Bmscs-Derived Exosomal miR-31-5p Promotes Lung Adenocarcinoma Development via WDR5-Induced Epithelial Mesenchymal Transition. Sleep and Breathing, 27, 1399-1409. [Google Scholar] [CrossRef] [PubMed]
[10] Yang, M., Zhou, W., Han, X., Xu, M., Wang, Z., Shi, M., et al. (2024) Modified Bone Marrow Mesenchymal Stem Cells Derived Exosomes Loaded with miRNA Ameliorates Non‐Small Cell Lung Cancer. Journal of Cellular and Molecular Medicine, 28, e70115. [Google Scholar] [CrossRef] [PubMed]
[11] Yan, W., Yang, H., Duan, D., Wu, Y., Liu, Y., Mao, J., et al. (2024) Bone Marrow Mesenchymal Stem Cells-Derived Exosomal miR-145-5p Reduced Non-Small Cell Lung Cancer Cell Progression by Targeting SOX9. BMC Cancer, 24, Article No. 883. [Google Scholar] [CrossRef] [PubMed]
[12] Sun, H., Zhu, R., Guo, X., Zhao, P., Zhang, R., Zhao, Z., et al. (2024) Exosome miR-101-3p Derived from Bone Marrow Mesenchymal Stem Cells Promotes Radiotherapy Sensitivity in Non-Small Cell Lung Cancer by Regulating DNA Damage Repair and Autophagy Levels through EZH2. Pathology-Research and Practice, 256, Article 155271. [Google Scholar] [CrossRef] [PubMed]
[13] Wu, T., Tian, Q., Liu, R., Xu, K., Shi, S., Zhang, X., et al. (2023) Inhibitory Role of Bone Marrow Mesenchymal Stem Cells‐Derived Exosome in Non‐Small‐Cell Lung Cancer: MicroRNA‐30b‐5p, EZH2 and Pi3k/Akt Pathway. Journal of Cellular and Molecular Medicine, 27, 3526-3538. [Google Scholar] [CrossRef] [PubMed]
[14] He, Y., Li, R., She, W., Ai, Y., Li, K., Kumeria, T., et al. (2023) Inhibitory Effects of the Nanoscale Lysate Derived from Xenogenic Dental Pulp Stem Cells in Lung Cancer Models. Journal of Nanobiotechnology, 21, Article No. 488. [Google Scholar] [CrossRef] [PubMed]
[15] Sengul, F., Vatansev, H. and Ozturk, B. (2023) Investigation the Effects of Bee Venom and H-Dental-Derived Mesenchymal Stem Cells on Non-Small Cell Lung Cancer Cells (A549). Molecular Biology Reports, 51, Article No. 2. [Google Scholar] [CrossRef] [PubMed]
[16] 袁哲, 吴思梦, 王亚君, 等. UC-MSC经PI3K/AKT信号通路影响人肺腺癌A549细胞的凋亡和增殖[J]. 中国肿瘤生物治疗杂志, 2019, 26(3): 260-265.
[17] Zhu, W., Xu, W., Jiang, R., Qian, H., Chen, M., Hu, J., et al. (2006) Mesenchymal Stem Cells Derived from Bone Marrow Favor Tumor Cell Growth in Vivo. Experimental and Molecular Pathology, 80, 267-274. [Google Scholar] [CrossRef] [PubMed]
[18] Karnoub, A.E., Dash, A.B., Vo, A.P., Sullivan, A., Brooks, M.W., Bell, G.W., et al. (2007) Mesenchymal Stem Cells within Tumour Stroma Promote Breast Cancer Metastasis. Nature, 449, 557-563. [Google Scholar] [CrossRef] [PubMed]
[19] Lis, R., Touboul, C., Mirshahi, P., Ali, F., Mathew, S., Nolan, D.J., et al. (2011) Tumor Associated Mesenchymal Stem Cells Protects Ovarian Cancer Cells from Hyperthermia through CXCL12. International Journal of Cancer, 128, 715-725. [Google Scholar] [CrossRef] [PubMed]
[20] Okumura, T., Wang, S.S., Takaishi, S., Tu, S.P., Ng, V., E Ericksen, R., et al. (2009) Identification of a Bone Marrow-Derived Mesenchymal Progenitor Cell Subset That Can Contribute to the Gastric Epithelium. Laboratory Investigation, 89, 1410-1422. [Google Scholar] [CrossRef] [PubMed]
[21] Stepanov, Y.V., Golovynska, I., Ostrovska, G., Pylyp, L., Dovbynchuk, T., Stepanova, L.I., et al. (2024) Human Mesenchymal Stem Cells Increase llc Metastasis and Stimulate or Decelerate Tumor Development Depending on Injection Method and Cell Amount. Cytometry Part A, 105, 252-265. [Google Scholar] [CrossRef] [PubMed]
[22] Ridge, S.M., Sullivan, F.J. and Glynn, S.A. (2017) Mesenchymal Stem Cells: Key Players in Cancer Progression. Molecular Cancer, 16, Article No. 31. [Google Scholar] [CrossRef] [PubMed]
[23] Galland, S. and Stamenkovic, I. (2019) Mesenchymal Stromal Cells in Cancer: A Review of Their Immunomodulatory Functions and Dual Effects on Tumor Progression. The Journal of Pathology, 250, 555-572. [Google Scholar] [CrossRef] [PubMed]
[24] Minev, T., Balbuena, S., Gill, J.M., Marincola, F.M., Kesari, S. and Lin, F. (2024) Mesenchymal Stem Cells—The Secret Agents of Cancer Immunotherapy: Promises, Challenges, and Surprising Twists. Oncotarget, 15, 793-805. [Google Scholar] [CrossRef] [PubMed]
[25] Meng, M., Zhang, W.W., Chen, S.F., Wang, D. and Zhou, C. (2024) Therapeutic Utility of Human Umbilical Cord-Derived Mesenchymal Stem Cells-Based Approaches in Pulmonary Diseases: Recent Advancements and Prospects. World Journal of Stem Cells, 16, 70-88. [Google Scholar] [CrossRef] [PubMed]
[26] Testa, U., Castelli, G. and Pelosi, E. (2018) Lung Cancers: Molecular Characterization, Clonal Heterogeneity and Evolution, and Cancer Stem Cells. Cancers, 10, Article 248. [Google Scholar] [CrossRef] [PubMed]
[27] Kamrani, S., Naseramini, R., Khani, P., Razavi, Z.S., Afkhami, H., Atashzar, M.R., et al. (2025) Mesenchymal Stromal Cells in Bone Marrow Niche of Patients with Multiple Myeloma: A Double-Edged Sword. Cancer Cell International, 25, Article No. 117. [Google Scholar] [CrossRef] [PubMed]

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