中性粒细胞胞外诱捕网介导的炎症–血栓反应在慢性阻塞性肺疾病并发静脉血栓栓塞症中的研究进展
Research Progress in Neutrophil Extracellular Trap-Mediated Thromboinflammatory Responses in Chronic Obstructive Pulmonary Disease Complicated with Venous Thromboembolism
DOI: 10.12677/acm.2026.1672540, PDF,   
作者: 侯 艳, 兰 月, 李灵娜, 黄 鑫, 黄 玲*：西南医科大学附属医院呼吸与危重症医学科，四川 泸州；绵阳市第三人民医院(四川省精神卫生中心)呼吸与危重症医学科，四川 绵阳
关键词: 慢性阻塞性肺疾病；中性粒细胞胞外诱捕网；静脉血栓栓塞症；综述；Chronic Obstructive Pulmonary Disease； Neutrophil Extracellular Trap； Venous Thromboembolism； Review
摘要: 慢性阻塞性肺疾病(COPD)患者并发静脉血栓栓塞症(VTE)的风险显著增加，其病理基础与慢性炎症和高凝状态之间的相互作用密切相关。中性粒细胞胞外诱捕网(NETs)因其同时参与炎症反应与凝血过程，可能是连接COPD与VTE的关键分子桥梁。本文介绍了NETs的生物学特性，并重点阐述了其在COPD气道炎症及血栓形成中的双重作用机制，指出NETs通过释放组蛋白、蛋白酶等成分，损伤血管内皮、激活凝血系统并放大炎症反应，从而驱动“炎症–血栓”恶性循环。本综述展现了靶向NETs作为一种兼具抗炎与抗栓潜力的治疗策略，为COPD相关VTE的防治提供了新视角。
Abstract: Patients with chronic obstructive pulmonary disease (COPD) exhibit a significantly increased risk of developing venous thromboembolism (VTE), with the pathological basis closely linked to the interplay between chronic inflammation and hypercoagulability. Neutrophil extracellular traps (NETs), which participate in both inflammatory responses and coagulation processes, may serve as a key molecular bridge connecting COPD and VTE. This review introduces the biological characteristics of NETs and highlights their dual mechanistic roles in COPD airway inflammation and thrombus formation. Specifically, NETs release components such as histones and proteases that damage vascular endothelium, activate the coagulation system, and amplify inflammatory responses, thereby driving a vicious cycle of “inflammation-thrombosis”. The review demonstrates that targeting NETs represents a potential therapeutic strategy with both anti-inflammatory and antithrombotic effects, offering novel perspectives for the prevention and treatment of COPD-associated VTE.
文章引用：侯艳, 兰月, 李灵娜, 黄鑫, 黄玲. 中性粒细胞胞外诱捕网介导的炎症–血栓反应在慢性阻塞性肺疾病并发静脉血栓栓塞症中的研究进展[J]. 临床医学进展, 2026, 16(7): 406-414. https://doi.org/10.12677/acm.2026.1672540

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