酚类化合物甲酰化反应研究进展
Research Progress on Formylation Reactions of Phenolic Compounds
DOI: 10.12677/amc.2026.143023, PDF,    科研立项经费支持
作者: 邱世林, 谭 成, 王圆媛, 薛 智*：阿坝师范学院资源与环境学院，四川 阿坝；吴 同：宜宾学院过程分析与控制四川省高校重点实验室，四川 宜宾
关键词: 酚；甲酰化；水杨醛；区域选择性；绿色合成；天然产物全合成；Phenol； Formylation； Salicylaldehyde； Regional Selectivity； Green Synthesis； Natural Products Are Fully Synthesized
摘要: 酚类化合物的甲酰化反应是构建芳香醛骨架的重要有机转化，所得产物水杨醛及其衍生物在药物、天然产物、功能材料和配体合成中作为关键中间体具有广泛应用。本文系统总结酚类甲酰化反应的研究进展，从经典方法如Reimer-Tiemann反应、Vilsmeier-Haack反应、Duff反应、Casnati-Skattebol反应出发，详细讨论各方法的特点、适用范围及局限性。在此基础上，重点介绍近年来发展的新型催化体系，包括金属催化、有机催化、非均相催化及光/电催化等绿色合成策略。此外，探讨甲酰化反应的区域选择性控制机制及其在复杂天然产物全合成中的应用，并对酚类甲酰化反应的未来发展方向进行展望。
Abstract: The formylation reaction of phenolic compounds is an important organic transformation of aromatic aldehyde skeleton, and the resulting products salicylaldehyde and its derivatives are widely used as key intermediates in the synthesis of drugs, natural products, functional materials and ligands. This paper systematically summarizes the research progress of phenolic formylation reactions, starting from classical methods such as Reimer-Tiemann reaction, Vilsmeier-Haack reaction, Duff reaction, and Casnati-Skattebol reaction, and discusses the characteristics, scope of application and limitations of each method in detail. On this basis, the new catalytic systems developed in recent years are introduced, including green synthesis strategies such as metal catalysis, organic catalysis, heterogeneous catalysis and photo/electrocatalysis. In addition, the regioselective control mechanism of formylation reaction and its application in the total synthesis of complex natural products are discussed, and the future development direction of phenolic formylation reaction is prospected.
文章引用：邱世林, 谭成, 王圆媛, 吴同, 薛智. 酚类化合物甲酰化反应研究进展[J]. 材料化学前沿, 2026, 14(3): 220-229. https://doi.org/10.12677/amc.2026.143023

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