大柴胡汤治疗功能性消化不良的研究进展

Research Progress of Da Chaihu Decoction in the Treatment of Functional Dyspepsia

摘要: 功能性消化不良(FD)作为一种临床常见疾病，严重影响人们的生活质量，临床以上腹部疼痛或烧灼感，餐后早饱感，饱胀感为主要临床表现，目前临床上缺乏有效且彻底的治疗措施。大柴胡汤方简效宏，是调理肝脾的经方验方，临床上常用于治疗胃痞，胃痛等消化系统疾病。临床研究证实大柴胡汤治疗FD疗效显著，可以明显改善患者抑郁焦虑精神状态，且复发率低，不良反应少；实验研究发现大柴胡汤主要是通过促进胃肠动力，降低内脏高敏感反应，修复肠道屏障，抑制炎症反应状态，调节肠道菌群以发挥其治疗作用。本文从中医理论、临床研究和基础实验等方面对大柴胡汤治疗FD进行讨论，旨在深入探究大柴胡汤治疗FD的新进展，以期为临床治疗FD提供新的思路和依据。

Abstract: Functional dyspepsia (FD), as a common clinical disease, seriously affects patients’ quality of life. Its main clinical manifestations include epigastric pain or burning sensation, postprandial early satiety, and fullness. Currently, there is a lack of effective and radical therapeutic measures in clinical practice. Da Chaihu Decoction is a classic and effective formula for regulating the liver and spleen, and is commonly used in the treatment of digestive system diseases such as gastric fullness and stomach pain. Clinical studies have confirmed that Da Chaihu Decoction has a significant therapeutic effect on FD, markedly improving patients’ depressive and anxious mental states, with a low recurrence rate and few adverse reactions. Experimental studies have revealed that Da Chaihu Decoction exerts its therapeutic effects mainly by promoting gastrointestinal motility, reducing visceral hypersensitivity, repairing the intestinal barrier, inhibiting the inflammatory response, and regulating the intestinal microbiota. This article discusses the treatment of FD with Da Chaihu Decoction from the perspectives of traditional Chinese medicine theory, clinical research, and basic experiments, aiming to explore new progress in the treatment of FD with Da Chaihu Decoction and to provide new ideas and evidence for clinical treatment of FD.