关于癌痛机制与治疗方法的研究现状： 一项系统性综述
Current Research Status on the Mechanisms and Treatment Methods of Cancer Pain: A Systematic Review
DOI: 10.12677/acm.2026.1672565, PDF,   
作者: 姬甜甜, 高彦东*, 边步荣：延安大学医学院，陕西 延安
关键词: 癌性疼痛；机制；治疗方法；Cancer Pain； Mechanism； Treatment Methods
摘要: 癌痛(cancer pain)是癌症患者因肿瘤本身发展、转移或治疗过程引发的持续性或间歇性疼痛，作为癌症患者的主要症状，普遍存在于癌症患者的每个阶段，困扰着大部分癌症患者，已经成为影响癌症患者生存质量和生存期的关键问题之一。据研究显示，对于晚期癌症患者，至少66%的患者会出现疼痛，且55%的患者会经历中度至重度疼痛。癌症相关疼痛会显著增加躯体痛苦，严重损害心理健康和日常生活质量，进一步加重患者的负担。因此本文将以癌性疼痛的外周和中枢机制与缓解治疗方法做一综述，以期为后续癌痛的机制探索和治疗方向提供思路。
Abstract: Cancer pain, defined as persistent or intermittent pain resulting from tumor progression, metastasis, or therapeutic interventions, constitutes a predominant symptom experienced by the majority of cancer patients across all disease stages. As a critical determinant impacting both quality of life and overall survival, it represents one of the most significant challenges in oncology care. Studies indicate that over 66% of patients with advanced cancer experience pain, among whom 55% report moderate to severe intensity. Cancer-related pain markedly exacerbates physical distress, impairs psychological well-being, and substantially compromises daily functioning, thereby imposing additional burdens on affected individuals. This review synthesizes current knowledge on the peripheral and central mechanisms underlying cancer pain and discusses contemporary therapeutic strategies for its alleviation, aiming to provide insights for future mechanistic investigations and treatment innovations.
文章引用：姬甜甜, 高彦东, 边步荣. 关于癌痛机制与治疗方法的研究现状： 一项系统性综述[J]. 临床医学进展, 2026, 16(7): 595-601. https://doi.org/10.12677/acm.2026.1672565

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