CD147在动脉粥样硬化中的研究进展

CD147 in Atherosclerosis: A Review of Recent Advances

摘要: CD147作为一种多效性跨膜糖蛋白，在动脉粥样硬化的形成过程中发挥重要作用。现有证据表明，它通过促进炎症反应、加速泡沫细胞形成、诱导细胞外基质降解以及活化血小板等多个环节，参与从斑块形成到破裂的全过程。其中部分机制已在动脉粥样硬化模型中得到直接验证，而其他机制的证据主要来源于其他疾病，其在动脉粥样硬化中的具体作用仍有待阐明。在临床转化方面，CD147作为评估斑块易损性和预后的生物标志物展现出一定潜力，但针对该靶点的干预策略仍处于早期探索阶段，尚需更多临床研究验证其安全性与有效性。

Abstract: CD147, a pleiotropic transmembrane glycoprotein, plays an important role in the development of atherosclerosis. Existing evidence indicates that it participates in the entire process from plaque formation to rupture by promoting inflammatory responses, accelerating foam cell formation, inducing extracellular matrix degradation, and activating platelets. Some of these mechanisms have been directly validated in atherosclerosis models, while evidence for others is primarily derived from other diseases, and their specific roles in atherosclerosis remain to be clarified. In terms of clinical translation, CD147 shows certain potential as a biomarker for assessing plaque vulnerability and prognosis. However, intervention strategies targeting this molecule are still in the early exploratory stage, and further clinical studies are needed to verify their safety and efficacy.