体成分失调介导肥胖对肝再生影响的研究进展
Research Progress on the Effect of Obesity on Liver Regeneration Mediated by Body Composition Imbalance
DOI: 10.12677/acm.2026.1672581, PDF,   
作者: 白 鸽, 张明月, 李 佳：青海省人民医院心血管超声室，青海 西宁；赵玲玲：青海省人民医院内分泌科，青海 西宁；王庆恩*：青海省人民医院甲乳外科，青海 西宁
关键词: 体成分失调；肥胖；肝再生；肌少性肥胖；肝移植；肌肉减少症；Body Composition Imbalance； Obesity； Liver Regeneration； Sarcopenic Obesity； Liver Transplantation； Sarcopenia
摘要: 传统体重指数(BMI)作为肥胖评估的单一指标存在显著局限性，仅能解释约17.6%的体重变异，而体成分的构成与分布特征更能揭示肥胖的病理本质。随着研究范式从BMI为中心向体成分为核心转变，体成分失调与肥胖及肝再生的关联日益受到关注。本文系统梳理了体成分失调的概念、分类体系及肥胖状态下的核心特征，总结了体成分检测技术与评估指标的应用现状，重点阐述了脂肪成分失调、肌肉失调介导肥胖对肝再生影响的核心机制，分析了少肌性肥胖对肝移植预后的影响及体成分异常的临床干预方向。研究表明，体成分失调是肥胖介导肝再生障碍的核心中间环节，通过信号通路紊乱、细胞器功能异常、代谢与炎症微环境改变等多途径影响肝再生，而针对性的临床干预可改善体成分失衡、优化肝再生及肝移植预后。本文为深入理解体成分失调与肥胖、肝再生的关联提供了理论支撑，也为相关疾病的精准评估与靶向干预提供了新的思路与方向。
Abstract: Traditional body mass index (BMI), as a single indicator for obesity assessment, has prominent limitations, which can only explain approximately 17.6% of body weight variation. In contrast, the composition and distribution characteristics of body components can better reveal the pathological essence of obesity. With the shift of research paradigm from BMI-centered to body composition-centered research, the association between body composition imbalance and obesity as well as liver regeneration has attracted increasing attention. This paper systematically sorts out the concept and classification system of body composition imbalance and its core characteristics under obese conditions, summarizes the application status of detection technologies and evaluation indicators for body composition, and mainly elaborates the core mechanisms by which fat component disorder and muscle disorder mediate the effects of obesity on liver regeneration. It also analyzes the impact of sarcopenic obesity on liver transplantation prognosis and the clinical intervention strategies for abnormal body composition. Studies have demonstrated that body composition imbalance serves as a core intermediate link in obesity-induced liver regeneration disorders, which affects liver regeneration via multiple pathways including dysregulated signaling pathways, abnormal organelle functions, and altered metabolic and inflammatory microenvironments. Targeted clinical interventions can ameliorate body composition imbalance, and optimize liver regeneration and liver transplantation prognosis. This review provides theoretical support for further understanding the correlations among body composition imbalance, obesity and liver regeneration, and offers novel ideas and directions for accurate assessment and targeted intervention of related diseases.
文章引用：白鸽, 赵玲玲, 张明月, 李佳, 王庆恩. 体成分失调介导肥胖对肝再生影响的研究进展[J]. 临床医学进展, 2026, 16(7): 737-747. https://doi.org/10.12677/acm.2026.1672581

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