|
[1]
|
Praca, E., Jalou, H., Krupp, N., Delecaris, A., Hatch, J., Slaven, J., et al. (2018) Effect of CPAP on Airway Reactivity and Airway Inflammation in Children with Moderate-Severe Asthma. Respirology, 24, 338-344. [Google Scholar] [CrossRef] [PubMed]
|
|
[2]
|
Chen, W., Puttock, E.J., Schatz, M., Crawford, W., Vollmer, W.M., Xie, F., et al. (2024) Risk Factors for Acute Asthma Exacerbations in Adults with Mild Asthma. The Journal of Allergy and Clinical Immunology: In Practice, 12, 2705-2716.e6. [Google Scholar] [CrossRef] [PubMed]
|
|
[3]
|
Verma, M., Verma, D. and Alam, R. (2021) Role of Type-2 Innate Lymphoid Cells (ILC2s) in Type-2 Asthma. Current Opinion in Allergy & Clinical Immunology, 22, 29-35. [Google Scholar] [CrossRef] [PubMed]
|
|
[4]
|
Miller, R.L., Grayson, M.H. and Strothman, K. (2021) Advances in Asthma: New Understandings of Asthma’s Natural History, Risk Factors, Underlying Mechanisms, and Clinical Management. Journal of Allergy and Clinical Immunology, 148, 1430-1441. [Google Scholar] [CrossRef] [PubMed]
|
|
[5]
|
Kim, M., Bae, C., Bok, S., Choi, H., Ahn, T., Cho, S., et al. (2023) Drug Development from Natural Products Based on the Pathogenic Mechanism of Asthma. International Journal of Molecular Sciences, 24, Article 12469. [Google Scholar] [CrossRef] [PubMed]
|
|
[6]
|
Liu, T., Woodruff, P.G. and Zhou, X. (2024) Advances in Non-Type 2 Severe Asthma: From Molecular Insights to Novel Treatment Strategies. European Respiratory Journal, 64, Article ID: 2300826. [Google Scholar] [CrossRef] [PubMed]
|
|
[7]
|
蔡鑫君, 张相彩, 徐颖颖. 以细胞因子为靶点的抗哮喘药物研究进展[J]. 中国临床药理学与治疗学, 2010, 15(3): 350-355.
|
|
[8]
|
Yang, D., Li, Y., Liu, T., Yang, L., He, L., Huang, T., et al. (2023) Il‐1β Promotes IL‐17A Production of ILC3s to Aggravate Neutrophilic Airway Inflammation in Mice. Immunology, 176, 16-32. [Google Scholar] [CrossRef] [PubMed]
|
|
[9]
|
张国祥, 许文龙. T淋巴细胞及其分泌的细胞因子与哮喘[J]. 蚌埠医学院学报, 2008, 33(1): 125-126.
|
|
[10]
|
Gauthier, M., Kale, S.L. and Ray, A. (2025) T1‐T2 Interplay in the Complex Immune Landscape of Severe Asthma. Immunological Reviews, 330, e70011. [Google Scholar] [CrossRef] [PubMed]
|
|
[11]
|
Olsthoorn, S.E.M., van Krimpen, A., Hendriks, R.W. and Stadhouders, R. (2025) Chronic Inflammation in Asthma: Looking Beyond the Th2 Cell. Immunological Reviews, 330, e70010. [Google Scholar] [CrossRef] [PubMed]
|
|
[12]
|
Gohal, G., Moni, S.S., Bakkari, M.A. and Elmobark, M.E. (2024) A Review on Asthma and Allergy: Current Understanding on Molecular Perspectives. Journal of Clinical Medicine, 13, Article 5775. [Google Scholar] [CrossRef] [PubMed]
|
|
[13]
|
Hammad, H., Ahmed, E. and Lambrecht, B.N. (2025) Immunotherapy for Asthma. Cellular & Molecular Immunology, 22, 1521-1532. [Google Scholar] [CrossRef]
|
|
[14]
|
Li, K., Ji, X., Tian, S., Li, J., Tian, Y., Ma, X., et al. (2025) Oxidative Stress in Asthma Pathogenesis: Mechanistic Insights and Implications for Airway Smooth Muscle Dysfunction. Cell and Tissue Research, 400, 17-34. [Google Scholar] [CrossRef] [PubMed]
|
|
[15]
|
周妍, 张旻. 中国《支气管哮喘防治指南(2024年版)》解读[J]. 诊断学理论与实践, 2025, 24(4): 415-422.
|
|
[16]
|
Koumpagioti, D., Dimitroglou, M., Mpoutopoulou, B., Moriki, D. and Douros, K. (2025) The Role of Oxidative Stress in the Pathogenesis of Childhood Asthma: A Comprehensive Review. Children, 12, Article 1110. [Google Scholar] [CrossRef]
|
|
[17]
|
Liu, Y., Zhang, M., Wang, T. and Zhang, J. (2025) Reactive Oxygen Species in Asthma: Regulators of Macrophage Polarization and Therapeutic Implications: A Narrative Review. Journal of Asthma and Allergy, 18, 1129-1146. [Google Scholar] [CrossRef] [PubMed]
|
|
[18]
|
Zhang, B., Feng, X., Tian, L., Xiao, B., Hou, L., Mo, B., et al. (2025) Epithelial-Mesenchymal Transition in Asthma: Its Role and Underlying Regulatory Mechanisms. Frontiers in Immunology, 16, Article 1519998. [Google Scholar] [CrossRef] [PubMed]
|
|
[19]
|
He, H., Ji, X., Cao, L., Wang, Z., Wang, X., Li, X., et al. (2023) Medicine Targeting Epithelial-Mesenchymal Transition to Treat Airway Remodeling and Pulmonary Fibrosis Progression. Canadian Respiratory Journal, 2023, Article ID: 3291957. [Google Scholar] [CrossRef] [PubMed]
|
|
[20]
|
Gebski, E.B., Anaspure, O., Panettieri, R.A. and Koziol-White, C.J. (2022) Airway Smooth Muscle and Airway Hyperresponsiveness in Asthma: Mechanisms of Airway Smooth Muscle Dysfunction. Minerva Medica, 113, 4-16. [Google Scholar] [CrossRef] [PubMed]
|
|
[21]
|
Sahnoon, L., Bajbouj, K., Mahboub, B., Hamoudi, R. and Hamid, Q. (2025) Targeting IL-13 and IL-4 in Asthma: Therapeutic Implications on Airway Remodeling in Severe Asthma. Clinical Reviews in Allergy & Immunology, 68, Article No. 44. [Google Scholar] [CrossRef] [PubMed]
|
|
[22]
|
Tiotiu, A., Steiropoulos, P., Novakova, S., Nedeva, D., Novakova, P., Chong-Neto, H., et al. (2025) Airway Remodeling in Asthma: Mechanisms, Diagnosis, Treatment, and Future Directions. Archivos de Bronconeumología, 61, 31-40. [Google Scholar] [CrossRef] [PubMed]
|
|
[23]
|
Yang, Z., Mao, W., Wang, J. and Yin, L. (2025) The Gut-Lung Axis in Asthma: Microbiota-Driven Mechanisms and Therapeutic Perspectives. Frontiers in Microbiology, 16, Article 1680521. [Google Scholar] [CrossRef]
|
|
[24]
|
Perez-Garcia, J., Cardenas, A., Lorenzo-Diaz, F. and Pino-Yanes, M. (2025) Precision Medicine for Asthma Treatment: Unlocking the Potential of the Epigenome and Microbiome. Journal of Allergy and Clinical Immunology, 155, 298-315. [Google Scholar] [CrossRef] [PubMed]
|
|
[25]
|
Fang, Z., Fu, Y., Yi, F., Chen, Z., Li, Y., Wang, Z., et al. (2025) Neural Control of the Pathophysiology of Allergic Airway Disease and Its Clinical Implications: A Focus on Allergic Rhinitis and Asthma. Journal of Allergy and Clinical Immunology, 156, 259-269. [Google Scholar] [CrossRef] [PubMed]
|
|
[26]
|
Kistemaker, L.E.M. and Prakash, Y.S. (2019) Airway Innervation and Plasticity in Asthma. Physiology, 34, 283-298. [Google Scholar] [CrossRef] [PubMed]
|
|
[27]
|
张亚军, 谭亚琴, 王丽. 哮喘中医证候的古代文献研究[J]. 内蒙古中医药, 2007, 26(3): 46-47.
|
|
[28]
|
Liu, Y., Zha, W., Ma, Y., Chen, F., Zhu, W., Ge, A., et al. (2015) Galangin Attenuates Airway Remodelling by Inhibiting TGF-β1-Mediated ROS Generation and MAPK/Akt Phosphorylation in Asthma. Scientific Reports, 5, Article No. 11758. [Google Scholar] [CrossRef] [PubMed]
|
|
[29]
|
Chunlian, W., Heyong, W., Jia, X., Jie, H., Xi, C. and Gentao, L. (2014) Magnolol Inhibits Tumor Necrosis Factor-Α-Induced ICAM-1 Expression via Suppressing NF-κB and MAPK Signaling Pathways in Human Lung Epithelial Cells. Inflammation, 37, 1957-1967. [Google Scholar] [CrossRef] [PubMed]
|
|
[30]
|
Li, J., Zheng, M., Wang, C., Jiang, J., Xu, C., Li, L., et al. (2020) Cryptotanshinone Attenuates Allergic Airway Inflammation through Negative Regulation of NF-κB and P38 MAPK. Bioscience, Biotechnology, and Biochemistry, 84, 268-278. [Google Scholar] [CrossRef] [PubMed]
|
|
[31]
|
Yu, Q., Shi, Y., Shu, C., Ding, X., Zhu, S., Shen, Z., et al. (2021) Andrographolide Inhibition of Th17-Regulated Cytokines and JAK1/STAT3 Signaling in Ova-Stimulated Asthma in Mice. Evidence-Based Complementary and Alternative Medicine, 2021, Article ID: 6862073. [Google Scholar] [CrossRef] [PubMed]
|
|
[32]
|
Zhang, H., Zhang, J., Pan, H., Yang, K. and Hu, C. (2024) Astragaloside IV Promotes the Pyroptosis of Airway Smooth Muscle Cells in Childhood Asthma by Suppressing HMGB1/RAGE Axis to Inactivate NF-κB Pathway. Autoimmunity, 57, Article ID: 2387100. [Google Scholar] [CrossRef] [PubMed]
|
|
[33]
|
Yang, X. and Wang, F. (2019) The Effect of Astragaloside IV on JAK2‐STAT6 Signalling Pathway in Mouse Model of Ovalbumin‐Induced Asthma. Journal of Animal Physiology and Animal Nutrition, 103, 1578-1584. [Google Scholar] [CrossRef] [PubMed]
|
|
[34]
|
Xu, L., Li, J., Zhang, Y., Zhao, P. and Zhang, X. (2017) Regulatory Effect of Baicalin on the Imbalance of Th17/Treg Responses in Mice with Allergic Asthma. Journal of Ethnopharmacology, 208, 199-206. [Google Scholar] [CrossRef] [PubMed]
|
|
[35]
|
Quan, J., Xie, D., Li, Z., Yu, X., Liang, Z., Chen, Y., et al. (2024) Luteolin Alleviates Airway Remodeling in Asthma by Inhibiting the Epithelial-Mesenchymal Transition via β-Catenin Regulation. Phytomedicine, 135, Article ID: 156090. [Google Scholar] [CrossRef] [PubMed]
|
|
[36]
|
Yang, X., Lv, J., Li, H., Jiao, B., Zhang, Q., Zhang, Y., et al. (2017) Curcumin Reduces Lung Inflammation via WNT/β-Catenin Signaling in Mouse Model of Asthma. Journal of Asthma, 54, 335-340. [Google Scholar] [CrossRef] [PubMed]
|
|
[37]
|
Jia, S., Guo, P., Lu, J., Huang, X., Deng, L., Jin, Y., et al. (2021) Curcumol Ameliorates Lung Inflammation and Airway Remodeling via Inhibiting the Abnormal Activation of the WNT/β-Catenin Pathway in Chronic Asthmatic Mice. Drug Design, Development and Therapy, 15, 2641-2651. [Google Scholar] [CrossRef] [PubMed]
|
|
[38]
|
Li, Z., Zheng, J., Zhang, N. and Li, C. (2016) Berberine Improves Airway Inflammation and Inhibits NF-κB Signaling Pathway in an Ovalbumin-Induced Rat Model of Asthma. Journal of Asthma, 53, 999-1005. [Google Scholar] [CrossRef] [PubMed]
|
|
[39]
|
Jin, H., Li, J., Zhang, M., Luo, R., Lu, P., Zhang, W., et al. (2021) Berberine-Loaded Biomimetic Nanoparticles Attenuate Inflammation of Experimental Allergic Asthma via Enhancing IL-12 Expression. Frontiers in Pharmacology, 12, Article 724525. [Google Scholar] [CrossRef] [PubMed]
|
|
[40]
|
Sun, D., Wang, J., Yang, N. and Ma, H. (2016) Matrine Suppresses Airway Inflammation by Downregulating SOCS3 Expression via Inhibition of NF-κB Signaling in Airway Epithelial Cells and Asthmatic Mice. Biochemical and Biophysical Research Communications, 477, 83-90. [Google Scholar] [CrossRef] [PubMed]
|
|
[41]
|
He, H., Cao, L., Wang, Z., Wang, Z., Miao, J., Li, X., et al. (2021) Sinomenine Relieves Airway Remodeling by Inhibiting Epithelial-Mesenchymal Transition through Downregulating TGF-β1 and Smad3 Expression in Vitro and in Vivo. Frontiers in Immunology, 12, Article 736479. [Google Scholar] [CrossRef] [PubMed]
|
|
[42]
|
Bao, H., Liu, X., Li, Y., Men, X. and Zeng, X. (2016) Sinomenine Attenuates Airway Inflammation and Remodeling in a Mouse Model of Asthma. Molecular Medicine Reports, 13, 2415-2422. [Google Scholar] [CrossRef] [PubMed]
|
|
[43]
|
Qin, Z., Chen, Y., Liu, N., Wang, Y., Su, L., Liang, B., et al. (2024) Mechanisms of Bushenyiqi Decoction in the Treatment of Asthma: An Investigation Based on Network Pharmacology with Experimental Validation. Frontiers in Pharmacology, 15, Article 1361379. [Google Scholar] [CrossRef] [PubMed]
|
|
[44]
|
Chen, Z., Zhou, Y., Tan, Y., He, S., Ji, X., Xiao, B., et al. (2024) Network Pharmacology Analysis and Experimental Validation of Xiao-Qing-Long-Tang’s Therapeutic Effects against Neutrophilic Asthma. Journal of Pharmaceutical and Biomedical Analysis, 243, Article ID: 116063. [Google Scholar] [CrossRef] [PubMed]
|
|
[45]
|
Liu, X., Shen, J., Fan, D., Qiu, X., Guo, Q., Zheng, K., et al. (2017) Yupingfeng San Inhibits NLRP3 Inflammasome to Attenuate the Inflammatory Response in Asthma Mice. Frontiers in Pharmacology, 8, Article 944. [Google Scholar] [CrossRef] [PubMed]
|
|
[46]
|
Xu, W., Zhao, R. and Yuan, B. (2021) The Therapeutic Effect of Traditional Liujunzi Decoction on Ovalbumin-Induced Asthma in BALB/C Mice. Canadian Respiratory Journal, 2021, Article ID: 6406295. [Google Scholar] [CrossRef] [PubMed]
|
|
[47]
|
Wei, L., Gou, X., Su, B., Han, H., Guo, T., Liu, L., et al. (2022) Mahuang Decoction Attenuates Airway Inflammation and Remodeling in Asthma via Suppression of the SP1/FGFR3/PI3K/AKT Axis. Drug Design, Development and Therapy, 16, 2833-2850. [Google Scholar] [CrossRef] [PubMed]
|
|
[48]
|
Chen, H., Xing, S., Wu, J., Li, Y., Yang, X., Wang, Z., et al. (2026) Zhichuanling Oral Liquid Attenuates Airway Inflammation in Asthma by Targeting the STIM1/CHOP/JNK Axis. Journal of Ethnopharmacology, 356, Article ID: 120859. [Google Scholar] [CrossRef]
|
|
[49]
|
Jiang, H., Bai, Z., Ou, Y., Liu, H., Si, Z., Liu, Y., et al. (2023) β-Hydroxybutyric Acid Upregulated by Suhuang Antitussive Capsule Ameliorates Cough Variant Asthma through GSK3β/AMPK-Nrf2 Signal Axis. Journal of Ethnopharmacology, 307, Article ID: 116013. [Google Scholar] [CrossRef] [PubMed]
|
|
[50]
|
Liu, B., Xiang, M., Zhou, M., Li, C., Xin, H., Zhang, S., et al. (2025) Pharmacological Effects and Mechanisms of Danlong Oral Liquid in Asthma Airway Remodeling: Insights from Serum Medicinal Chemistry, Network Pharmacology, and Experimental Validation. Journal of Ethnopharmacology, 340, Article ID: 119259. [Google Scholar] [CrossRef] [PubMed]
|
|
[51]
|
Kao, S., Wang, S., Lin, C. and Lin, L. (2018) Jin Gui Shen Qi Wan, a Traditional Chinese Medicine, Alleviated Allergic Airway Hypersensitivity and Inflammatory Cell Infiltration in a Chronic Asthma Mouse Model. Journal of Ethnopharmacology, 227, 181-190. [Google Scholar] [CrossRef] [PubMed]
|
|
[52]
|
Yuan, J., Wang, Y., Sha, B., Zhang, Y., Mokuy, O.O.E.M., Jin, M., et al. (2025) Network Pharmacology and Experimental Validation of Inflammation Inhibition by Chuankezhi Injection in Treating Asthma. Phytomedicine, 143, Article ID: 156891. [Google Scholar] [CrossRef] [PubMed]
|