炎症信号介导糖尿病周围神经痛与睡眠障碍的共病研究进展
Research Progress on Inflammatory Signals Mediating the Comorbidity of Diabetic Peripheral Neuropathia and Sleep Disorders
摘要: 糖尿病周围神经痛(DPN)是糖尿病高发的慢性并发症,发病过程伴随代谢紊乱、氧化应激与多条炎症信号通路异常激活。神经炎症信号不仅贯穿DPN发生、发展全过程,更是串联DPN与睡眠障碍的核心枢纽,二者形成双向恶性循环。本文系统综述DPN与睡眠障碍的交互作用机制,重点探讨各类炎症信号通路的调控作用,深度剖析二者互作的分子基础,以期为该类共病的临床防治提供新的理论依据与潜在治疗靶点。
Abstract: Diabetic peripheral neuralgia (DPN) is a common chronic complication of diabetes, which is accompanied by metabolic disorder, oxidative stress and abnormal activation of multiple inflammatory signaling pathways. Neuroinflammatory signals run through the whole process of DPN and act as a core hub linking DPN and sleep disorders, forming a two-way vicious cycle. This paper systematically reviews the interaction mechanism between DPN and sleep disorders, focuses on the regulatory effect of inflammatory signaling pathways, and deeply analyzes the molecular basis of their interaction, so as to provide new theoretical basis and potential therapeutic targets for the clinical prevention and treatment of this comorbidity.
文章引用:张淇茹, 刘延峰. 炎症信号介导糖尿病周围神经痛与睡眠障碍的共病研究进展[J]. 临床医学进展, 2026, 16(7): 1057-1064. https://doi.org/10.12677/acm.2026.1672618

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