ATP结合盒A亚家族成员2 (ABCA2)在多种神经系统疾病中的作用
The Role of ATP-Binding Cassette Subfamily A Member 2 (ABCA 2) in Various Neurological Diseases
摘要: ATP结合盒A亚家族成员2 (ABCA2)在脑组织中表达量很高，它主要是一种具有多种功能的内溶酶体膜蛋白。多种神经系统疾病都涉及到ABCA2。此前，大量研究表明ABCA2与阿尔茨海默病有关，最近的研究表明，ABCA2还是其他神经系统疾病，如智力发育障碍；共济失调；构音障碍和少突胶质细胞瘤等的潜在因素。本文就ABCA2与相关的神经系统疾病研究作如下综述。
Abstract: ATP-Binding cassette subfamily A member 2 (ABCA2) is highly expressed in brain tissue and is mainly an endolysosomal membrane protein with various functions. ABCA2 has been implicated in a variety of neurological diseases. Previously, numerous studies have shown that ABCA2 is associated with Alzheimer’s disease and recent studies have shown that ABCA2 is also a potential factor for other neurological diseases, such as intellectual developmental disorder; ataxia; dysarthria and oligodendroglioma. This article reviews the research on ABCA2 and related nervous system diseases as follows.
文章引用：顾令文, 吴江. ATP结合盒A亚家族成员2 (ABCA2)在多种神经系统疾病中的作用[J]. 临床医学进展, 2026, 16(7): 1194-1199. https://doi.org/10.12677/acm.2026.1672633

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