跨膜蛋白TMEM33及其在相关疾病中的研究 进展
Research Progress of Transmembrane Protein TMEM33 and Its Application in Related Diseases
摘要: 跨膜蛋白33 (transmembrane protein 33, TMEM33)属于跨膜蛋白家族，特点在于拥有3个跨膜域，其主要定位于内质网，参与调节内质网应激中未折叠蛋白反应、细胞内钙稳态、细胞脂质代谢以及在肿瘤细胞的一些行为中发挥调节作用，目前研究证实TMEM33与血管生成、急性肾损伤、部分肿瘤的发生发展具有相关性。本文旨在对TMEM33的发现与结构特点、主要生物学功能及与相关疾病的联系进行全面总结，以期能够为进一步探究TMEM33的功能、揭示其在相关疾病的发病机制和功能作用，以及为疾病的临床诊疗提供新的参考思路。
Abstract: Transmembrane protein 33 (TMEM33) belongs to the transmembrane protein family. It is characterized by having three transmembrane domains and is mainly located in the endoplasmic reticulum. TMEM33 is involved in regulating unfolded protein responses during endoplasmic reticulum stress, intracellular calcium homeostasis, cellular lipid metabolism, and plays a regulatory role in some behaviors of tumor cells. Current research has confirmed that TMEM33 is correlated with angiogenesis, acute kidney injury, and the occurrence and development of some tumors. This article aims to comprehensively summarize the discovery and structural characteristics of TMEM33, its main biological functions, and its connection with related diseases, with the expectation of providing new reference ideas for further exploring the functions of TMEM33, revealing its pathogenesis and functional roles in related diseases, and for the clinical diagnosis and treatment of diseases.
文章引用：时拥月, 李小波. 跨膜蛋白TMEM33及其在相关疾病中的研究 进展[J]. 临床医学进展, 2026, 16(7): 1227-1237. https://doi.org/10.12677/acm.2026.1672637

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