胶质–淋巴系统功能障碍与视神经疾病的关联机制及研究进展
Mechanisms and Research Progress of the Association between Glymphatic System Dysfunction and Optic Neuropathies
摘要: 近期研究在啮齿类动物中发现了一种类淋巴系统，即胶质–淋巴系统，且越来越多的研究证实人眼中存在类似通路。胶质–淋巴系统的发现改变了我们对脑脊液循环和眼部代谢废物清除的传统认知。本文综述了国内外最新研究成果，围绕胶质–淋巴系统障碍的致病机制，总结了胶质–淋巴系统功能障碍在视神经疾病，例如青光眼、缺血性视神经病变、视神经脊髓炎谱系疾病和高颅压性视乳头水肿中的潜在作用和诊疗前景，以期为未来研究胶质–淋巴系统在视神经疾病中的作用提供参考。
Abstract: Recent studies have identified a lymphatic-like system, the glymphatic system, in rodents, and increasing evidence suggests the presence of similar pathways in the human eye. The discovery of the glymphatic system has changed our traditional understanding of cerebrospinal fluid circulation and metabolic waste clearance in eyes. This article reviews the latest research findings from both domestic and international sources, focusing on the pathogenic mechanisms underlying glymphatic system dysfunction, to summarize the potential role and therapeutic prospects of glymphatic system dysfunction in optic neuropathies such as glaucoma, ischemic optic neuropathy, neuromyelitis optica spectrum disorders, and papilledema caused by elevated intracranial pressure, aiming to provide a reference for future research on the role of the glymphatic system in optic nerve diseases.
文章引用：王梓默. 胶质–淋巴系统功能障碍与视神经疾病的关联机制及研究进展[J]. 临床医学进展, 2026, 16(7): 1297-1303. https://doi.org/10.12677/acm.2026.1672645

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