中医药治疗动脉粥样硬化研究热点可视化 分析

Visual Analysis of Research Hotspots in Traditional Chinese Medicine for the Treatment of Atherosclerosis

摘要: 目的：基于文献计量学方法，分析中医药治疗动脉粥样硬化(AS)领域的研究现状、热点主题与演进趋势，为该领域后续研究提供数据支撑和方向参考。方法：检索中国知网(CNKI)数据库自1965年11月至2026年1月15日收录的中医药治疗动脉粥样硬化的相关文献，经筛选后纳入CiteSpace软件进行可视化分析。对发文量年度分布进行分析，对作者、研究机构进行共现分析，对关键词进行共现、聚类及突现分析，以揭示该领域的研究脉络与发展趋势。结果：1965年以来，该领域发文量总体呈上升趋势，2004年后进入快速增长阶段，近年来维持在较高水平。研究力量以辽宁中医药大学及其附属医院为核心，形成以杨关林、贾连群等为代表的高产团队。机构合作多局限于高校及其附属医院内部，跨区域合作较少。关键词分析显示，研究热点由早期的“中医证型”“临床观察”逐步转向“炎症反应”“自噬”“细胞焦亡”“肠道菌群”“信号通路”等微观机制领域，网络药理学、分子对接等方法应用日益广泛。结论：中医药治疗AS研究正处于快速发展阶段，研究主题从宏观证候向微观机制深入，细胞自噬、肠道菌群、炎症调控等成为当前研究前沿。未来应加强多学科交叉与国际合作，推动基础研究成果向临床转化。

Abstract: Objective: To analyze the research status, hotspots and evolutionary trends in the field of traditional Chinese medicine (TCM) for atherosclerosis (AS) using bibliometric methods, and to provide data support and reference for future research. Methods: Relevant literatures on TCM treatment of AS from November 1965 to January 15, 2026 were retrieved from CNKI. After screening, CiteSpace was used for visual analysis, including annual publication distribution, author and institution co-occurrence, and keyword co-occurrence, clustering and burst analysis. Results: Publications on TCM for AS have increased overall since 1965, accelerated after 2004 and remained high in recent years. Liaoning University of TCM and its affiliated hospitals are the core research force, with productive teams led by Yang Guanlin and Jia Lianqun. Institutional collaboration is mostly internal, with limited cross‑regional cooperation. Research focus has shifted from “TCM syndromes” and “clinical observation” to microscopic mechanisms including “inflammation”, “autophagy”, “pyroptosis”, “gut microbiota” and “signaling pathways”, with growing use of network pharmacology and molecular docking. Conclusion: Research on TCM for AS is rapidly developing, moving from macroscopic syndromes to microscopic mechanisms. Autophagy, gut microbiota and inflammation regulation are current frontiers. Future research should strengthen interdisciplinary and international collaboration to promote clinical translation.