益气养阴法治疗胃癌前病变作用机制的研究 进展
Research Progress on Mechanisms of Qi-Tonifying and Yin-Nourishing Method in Treating Gastric Precancerous Lesions
DOI: 10.12677/tcm.2026.157368, PDF,   
作者: 刘小颖：黑龙江中医药大学研究生院，黑龙江 哈尔滨；梁国英*：黑龙江中医药大学附属第一医院消化一科，黑龙江 哈尔滨
关键词: 中医药；益气养阴法；胃癌前病变；作用机制；Traditional Chinese Medicine； Qi-Tonifying and Yin-Nourishing Method； Gastric Precancerous Lesions； Mechanisms
摘要: 归纳总结益气养阴法治疗PLGC作用机制的研究进展，并系统综述具有益气养阴功效的中药及其活性成分(如人参皂苷、黄芪甲苷、石斛多糖等)，以及体现该法的复方制剂(如益胃汤、麦门冬汤、健运清化方等)可通过调节炎症因子水平、抑制胃黏膜萎缩、延缓病理进程、介导肿瘤细胞增殖与凋亡、调控铁死亡和维持血管生成微环境的稳态等多种方式发挥作用，从而在一定程度上有效阻断甚至逆转其向胃癌的恶性转化。
Abstract: This review synthesizes the mechanistic basis of the Qi-tonifying and Yin-nourishing method for gastric precancerous lesions (PLGC) and systematically evaluates its representative agents. We detail how key bioactive compounds (e.g., ginsenosides, astragaloside IV, Dendrobium polysaccharides) and classical formulations (e.g., Yiwei Decoction, Maidong Decoction, Jianyun Qinghua Formula) exert their effects through multi-targeted actions. These include modulating inflammatory cytokines, inhibiting gastric mucosal atrophy, balancing cell proliferation and apoptosis, regulating ferroptosis, and stabilizing the angiogenic microenvironment. Collectively, evidence indicates that this therapeutic strategy can effectively retard disease progression and shows potential to block or even reverse the malignant transformation to gastric cancer.
文章引用：刘小颖, 梁国英. 益气养阴法治疗胃癌前病变作用机制的研究 进展[J]. 中医学, 2026, 15(7): 121-128. https://doi.org/10.12677/tcm.2026.157368

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