基于神经科学亚型分层构建卒中后感觉障碍 精准针灸治疗新范式的思考
Thoughts on Constructing a New Paradigm of Precise Acupuncture Treatment for Post-Stroke Sensation Disorders Based on Neuroscience-Based Subtype Stratification
摘要: 本文针对卒中后感觉障碍(Post-stroke Sensation Disorders)高发但治疗缺乏精准性的现状,系统构建了基于神经机制的多维亚型分层框架,将其分为初级感觉缺失型、皮质整合障碍型、感觉过敏型及非优势半球特殊型。文章强调,不同亚型对应不同的神经通路损害与临床表现,应开展个体化评估。在此基础上,提出了评估–分型–靶向干预–监测调整的精准针灸治疗新范式,结合现代神经影像与电生理技术,为不同亚型匹配特异性针刺策略,旨在推动针灸治疗从经验化走向科学化与精准化,提升康复效果。
Abstract: This article addresses the fact that post-stroke sensation disorders are common but lack precise treatment. It systematically builds a multi-dimensional subtype framework based on neural mechanisms, dividing them into primary sensory loss type, cortical integration disorder type, sensory hypersensitivity type, and non-dominant hemisphere special type. The article emphasizes that different subtypes correspond to different neural pathway damages and clinical manifestations, so individualized assessment should be conducted. Based on this, a new precise acupuncture treatment model is proposed, following an assessment-classification-targeted intervention-monitoring adjustment approach. By combining modern neuroimaging and electrophysiological techniques, specific acupuncture strategies are matched to different subtypes, aiming to move acupuncture treatment from an experience-based to a scientific and precise practice, improving rehabilitation outcomes.
文章引用:彭静. 基于神经科学亚型分层构建卒中后感觉障碍 精准针灸治疗新范式的思考[J]. 中医学, 2026, 15(7): 148-158. https://doi.org/10.12677/tcm.2026.157372

参考文献

[1] GBD 2021 Stroke Risk Factor Collaborators (2024) Global, Regional, and National Burden of Stroke and Its Risk Factors, 1990-2021: A Systematic Analysis for the Global Burden of Disease Study 2021. The Lancet Neurology, 23, 973-1003.
[2] Feigin, V.L. and Owolabi, M.O. (2023) Pragmatic Solutions to Reduce the Global Burden of Stroke: A World Stroke Organization-Lancet Neurology Commission. The Lancet Neurology, 22, 1160-1206. [Google Scholar] [CrossRef
[3] Fuseya, H., Tashiro, S., Takahashi, O., Kobayashi, Y., Tsuji, T. and Mizuno, K. (2025) Somatosensory‐Evoked Potentials and Clinical Assessments of Sensory Function over Time in Patients with Subacute Stroke. Neural Plasticity, 2025, Article ID: 7939662. [Google Scholar] [CrossRef] [PubMed]
[4] Kim, J.S. (2003) Central Post-Stroke Pain or Paresthesia in Lenticulo-Capsular Hemorrhages. Neurology, 61, 679-682. [Google Scholar] [CrossRef] [PubMed]
[5] Asseyer, S., Panagoulas, E., Maidhof, J., Villringer, K., Al, E., Chen, X., et al. (2024) Prediction of Central Post‐stroke Pain by Quantitative Sensory Testing. Annals of Neurology, 97, 507-520. [Google Scholar] [CrossRef] [PubMed]
[6] Haslam, B.S., Butler, D.S., Kim, A.S. and Carey, L.M. (2023) Somatosensory Impairment and Chronic Pain Following Stroke: An Observational Study. International Journal of Environmental Research and Public Health, 20, Article 906. [Google Scholar] [CrossRef] [PubMed]
[7] 贾杰. 脑卒中上肢康复: 手脑感知与手脑运动[J]. 中国康复医学杂志, 2020, 35(4): 385-389.
[8] Kenzie, J.M., Rajashekar, D., Goodyear, B.G. and Dukelow, S.P. (2023) Resting State Functional Connectivity Associated with Impaired Proprioception Post‐Stroke. Human Brain Mapping, 45, e26541. [Google Scholar] [CrossRef] [PubMed]
[9] 林衍声, 林嘉滢, 周钰馨. 社区脑卒中患者上肢躯体感觉功能障碍康复中国专家共识(2025版) [J]. 中国医刊, 2025, 60(9): 1025-1034.
[10] 杨宇琦, 山磊, 厉含之, 等. 中文版改良诺丁汉感觉功能评价量表的建立及信效度检验[J]. 中国康复医学杂志, 2021, 36(11): 1378-1383.
[11] 刘慧华, 王颖敏, 何晓阔, 等. 单次电针与经皮穴位电刺激治疗前后体感诱发电位的比较[J]. 中国康复理论与实践, 2017, 23(2): 185-188.
[12] Zhu, X., Tang, H.D., Dong, W.Y., Kang, F., Liu, A., Mao, Y., et al. (2021) Distinct Thalamocortical Circuits Underlie Allodynia Induced by Tissue Injury and by Depression-Like States. Nature Neuroscience, 24, 542-553. [Google Scholar] [CrossRef] [PubMed]
[13] Huang, T., Fu, G., Gao, J., Zhang, Y., Cai, W., Wu, S., et al. (2020) FGR Contributes to Hemorrhage-Induced Thalamic Pain by Activating NF-κB/ERK1/2 Pathways. JCI Insight, 5, e139987. [Google Scholar] [CrossRef] [PubMed]
[14] Schulz, R., Koch, P., Zimerman, M., Wessel, M., Bönstrup, M., Thomalla, G., et al. (2015) Parietofrontal Motor Pathways and Their Association with Motor Function after Stroke. Brain, 138, 1949-1960. [Google Scholar] [CrossRef] [PubMed]
[15] Malhotra, P., Coulthard, E.J. and Husain, M. (2009) Role of Right Posterior Parietal Cortex in Maintaining Attention to Spatial Locations over Time. Brain, 132, 645-660. [Google Scholar] [CrossRef] [PubMed]
[16] Wan, S., Liu, K., Zhao, J., Xu, J., Chen, X., Shu, H., et al. (2025) Case Report: Multidimensional Analgesia via Asymmetric Dual-Target Deep Brain Stimulation of the Periaqueductal Gray and Ventral Posterior Thalamus in Central Post-Stroke Pain. Neurology and Therapy, 14, 2751-2764. [Google Scholar] [CrossRef
[17] Steinhoff, M., Schmelz, M., Szabó, I.L. and Oaklander, A.L. (2018) Clinical Presentation, Management, and Pathophysiology of Neuropathic Itch. The Lancet Neurology, 17, 709-720. [Google Scholar] [CrossRef] [PubMed]
[18] Feinberg, T.E., Venneri, A., Simone, A.M., Fan, Y. and Northoff, G. (2010) The Neuroanatomy of Asomatognosia and Somatoparaphrenia. Journal of Neurology, Neurosurgery & Psychiatry, 81, 276-281. [Google Scholar] [CrossRef] [PubMed]
[19] 张哲, 郑丽娜, 杨中华, 等. 重症脑血管病临床研究20年[J]. 中国卒中杂志, 2025, 20(5): 555-565.
[20] 邵芃, 贾杰. 单侧脑卒中患者上肢感觉功能障碍临床特征分析[J]. 康复学报, 2022, 32(6): 527-532.
[21] 李晓东, 刘爱国, 吴秀玲, 等. 针刺对不同分型脑卒中神经功能缺损的疗效观察[J]. 河北中医, 2009, 31(7): 1033-1035.
[22] Solomon, D.H., Barohn, R.J., Bazan, C. and Grissom, J. (1994) The Thalamic Ataxia Syndrome. Neurology, 44, 810-810. [Google Scholar] [CrossRef] [PubMed]
[23] 董悦, 董玉茹, 姜胤, 等. 手针、电针及经皮穴位电刺激调节人脑功能的功能性磁共振观察[J]. 中国疼痛医学杂志, 2013, 19(2): 75-79.
[24] Sridhar, A., Mawla, I., Ichesco, E., Pluimer, B., Harte, S.E., Edwards, R., et al. (2026) Brain Sensory Network Activity Underlies Reduced Nociceptive Initiated and Nociplastic Pain via Acupuncture in Fibromyalgia. Communications Medicine, 6, Article No. 25. [Google Scholar] [CrossRef
[25] Yoon, D., Lee, S., Kim, J., Kim, K., Park, H., Napadow, V., et al. (2023) Graded Brain fMRI Response to Somatic and Visual Acupuncture Stimulation. Cerebral Cortex, 33, 11269-11278. [Google Scholar] [CrossRef] [PubMed]
[26] Xu, H., Yang, Y., Deng, Q., Zhang, B., Ruan, J., Jin, H., et al. (2021) Governor Vessel Electro-Acupuncture Promotes the Intrinsic Growth Ability of Spinal Neurons through Activating Calcitonin Gene-Related Peptide/α-Calcium/Calmodulin-Dependent Protein Kinase/neurotrophin-3 Pathway after Spinal Cord Injury. Journal of Neurotrauma, 38, 734-745. [Google Scholar] [CrossRef] [PubMed]
[27] Kim, H., Mawla, I., Lee, J., Gerber, J., Walker, K., Kim, J., et al. (2020) Reduced Tactile Acuity in Chronic Low Back Pain Is Linked with Structural Neuroplasticity in Primary Somatosensory Cortex and Is Modulated by Acupuncture Therapy. NeuroImage, 217, Article ID: 116899. [Google Scholar] [CrossRef] [PubMed]
[28] Lee, H., Lee, J., Jung, D., Oh, H., Shin, H. and Choi, B. (2024) Neuroprotection of Transcranial Cortical and Peripheral Somatosensory Electrical Stimulation by Modulating a Common Neuronal Death Pathway in Mice with Ischemic Stroke. International Journal of Molecular Sciences, 25, 7546. [Google Scholar] [CrossRef] [PubMed]
[29] Peng, W., Yang, T., Yuan, J., Huang, J. and Liu, J. (2020) Electroacupuncture-Induced Plasticity between Different Representations in Human Motor Cortex. Neural Plasticity, 2020, Article ID: 8856868. [Google Scholar] [CrossRef] [PubMed]
[30] 黄键澎, 朱玉, 张芷晴, 等. 电针太冲对大脑感觉皮层诱发电位的影响[J]. 针刺研究, 2021, 46(1): 69-72.
[31] 祝鹏宇, 井天依, 许娜, 等. 孙申田经颅针刺刺激疗法介绍[J]. 中华中医药杂志, 2021, 36(4): 2254-2256.
[32] Liu, C.H., Yang, M.H., Zhang, G.Z., Wang, X., Li, B., Li, M., et al. (2020) Neural Networks and the Anti-Inflammatory Effect of Transcutaneous Auricular Vagus Nerve Stimulation in Depression. Journal of Neuroinflammation, 17, Article No. 54. [Google Scholar] [CrossRef] [PubMed]
[33] Shen, D., Yang, B., Li, J., Zhang, J., Li, Y., Zhang, G., et al. (2025) The Potential Associations between Acupuncture Sensation and Brain Functional Network: A EEG Study. Cognitive Neurodynamics, 19, Article No. 49. [Google Scholar] [CrossRef] [PubMed]
[34] 苏菁菁, 范磊, 李旻瑶, 等. 醒脑开窍针刺法联合重复经颅磁刺激治疗卒中后认知障碍的疗效分析[J]. 时珍国医国药, 2024, 35(15): 3421-3423.
[35] Qi, S., Lin, D., Lin, L., Huang, X., Lin, S., Yu, Y., et al. (2020) Using Nonlinear Dynamics and Multivariate Statistics to Analyze EEG Signals of Insomniacs with the Intervention of Superficial Acupuncture. Evidence-Based Complementary and Alternative Medicine, 2020, Article ID: 8817843. [Google Scholar] [CrossRef] [PubMed]
[36] Yu, H., Li, F., Liu, J., Liu, C., Li, G. and Wang, J. (2024) Spatiotemporal Dynamics of Periodic and Aperiodic Brain Activity under Peripheral Nerve Stimulation with Acupuncture. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 32, 3993-4003. [Google Scholar] [CrossRef] [PubMed]
[37] Kong, Q., Sacca, V., Walker, K., Hodges, S. and Kong, J. (2023) Thalamocortical Mechanisms Underlying Real and Imagined Acupuncture. Biomedicines, 11, Article 1830. [Google Scholar] [CrossRef] [PubMed]
[38] Peng, J., Su, J., Song, L., Lv, Q., Gao, Y., Chang, J., et al. (2023) Altered Functional Activity and Functional Connectivity of Seed Regions Based on ALFF Following Acupuncture Treatment in Patients with Stroke Sequelae with Unilateral Limb Numbness. Neuropsychiatric Disease and Treatment, 19, 233-245. [Google Scholar] [CrossRef] [PubMed]
[39] Yu, Q., Sun, X., Chen, J., Li, M., Wang, X., Su, Y., et al. (2026) Distinct Intensity of Electroacupuncture Ameliorates Mechanical Hypersensitivity by Attenuating Neuronal Sensitization in Spinal Dorsal Horn in a Rat Model of Inflammatory Muscle Pain. Journal of Integrative Medicine, 24, 443-453. [Google Scholar] [CrossRef
[40] Ge, W., Zhan-Mu, O., Chen, C., Zhang, H., Wang, X., Liu, X., et al. (2022) Electroacupuncture Reduces Chronic Itch via Cannabinoid CB1 Receptors in the Ventrolateral Periaqueductal Gray. Frontiers in Pharmacology, 13, Article 931600. [Google Scholar] [CrossRef] [PubMed]
[41] Shi, J.F., Cao, W.Y., Zhang, X.N., Wan, H.Y., Su, Y.S., Qu, Z.Y., et al. (2023) Local Analgesia of Electroacupuncture Is Mediated by the Recruitment of Neutrophils and Released β-Endorphins. Pain, 164, 1965-1975. [Google Scholar] [CrossRef] [PubMed]
[42] Lu, Z., Huo, T., Deng, J., et al. (2022) Transcutaneous Electrical Acupoint Stimulation Induced Sedative Effects in Healthy Volunteers: A Resting-State fMRI Study. Frontiers in Human Neuroscience, 16, Article 843186. [Google Scholar] [CrossRef] [PubMed]
[43] Ali, U., Apryani, E., Wu, H.Y., Mao, X.F., Liu, H. and Wang, Y.Y. (2020) Low Frequency Electroacupuncture Alleviates Neuropathic Pain by Activation of Spinal Microglial Il-10/β-Endorphin Pathway. Biomedicine & Pharmacotherapy, 125, Article ID: 109898. [Google Scholar] [CrossRef] [PubMed]
[44] 王铁刚, 孙忠人, 戴缙, 等. 经颅重复针刺刺激疗法对慢性疲劳综合征脑功能调控的fMRI研究[J]. 临床放射学杂志, 2024, 43(1): 139-145.
[45] 刘西花, 于子夫, 马赛, 等. 针刺同步运动疗法改善脑卒中患者下肢感觉及运动功能的效果研究[J]. 中国康复医学杂志, 2025, 40(11): 1674-1678.
[46] 刘倩, 郭晓媛, 周炜, 等. 温针灸治疗缺血性卒中后偏身感觉障碍的疗效观察[J]. 上海针灸杂志, 2023, 42(9): 933-938.
[47] Tang, X., Shi, J., Lin, S., He, Z., Cui, S., Di, W., et al. (2024) Pyramidal and Parvalbumin Neurons Modulate the Process of Electroacupuncture Stimulation for Stroke Rehabilitation. iScience, 27, Article ID: 109695. [Google Scholar] [CrossRef] [PubMed]
[48] Chang, X., Hao, P., Zhang, S., Dang, Y., Liu, A., Zheng, N., et al. (2024) Multi-Scale Analysis of Acupuncture Mechanisms for Motor and Sensory Cortex Activity Based on SEEG Data. Cerebral Cortex, 34, bhae127. [Google Scholar] [CrossRef] [PubMed]
[49] 彭景, 邹忆怀, 宋蕾, 等. “形神共调”针法调节中风后肢体麻木患者大脑局部一致性的功能磁共振研究[J]. 中国中医药信息杂志, 2022, 29(11): 109-114.
[50] 朱雪梅, 于学平, 马慧慧. 调神通络针刺法治疗中风后偏身麻木的疗效观察[J]. 广州中医药大学学报, 2021, 38(6): 1168-1172.
[51] 闫凯, 薛原, 尹贵荣. 腕踝针联合甲钴胺治疗缺血性脑卒中患者偏身感觉障碍的临床效果[J]. 中国老年学杂志, 2021, 41(18): 3917-3920.
[52] 李瑞青, 王艺莹, 梅紧紧, 等. 腕踝针治疗中风后肩手综合征Ⅰ期临床疗效观察[J]. 中国针灸, 2022, 42(7): 721-725.
[53] Song, Y., Ni, J., Yuan, J., et al. (2025) Effects of Low-Frequency and High-Frequency Electroacupuncture Pretreatment on the COX-2/mPGES-1/PGE2 Pathway in a Rat Model of Cold-Coagulation Dysmenorrhea. Frontiers in Immunology, 16, Article 1563626. [Google Scholar] [CrossRef] [PubMed]
[54] 宁可星, 刘少鹏, 林立军, 等. 高维滨“脑部电场”疗法治疗脑梗死恢复期临床经验撷菁[J]. 中国针灸, 2024, 44(11): 1299-1303.
[55] 曾婧纯, 陈悦轩, 李晶晶, 等. 火针对化疗所致神经病理性疼痛大鼠外周敏化的镇痛作用机制[J]. 针刺研究, 2023, 48(11): 1095-1102.
[56] 袁景, 林桦, 许磊, 等. 沉浸式虚拟现实训练联合穴位针刺对脑卒中患者单侧空间忽略的影响[J]. 康复学报, 2025, 35(4): 363-369, 377.
[57] 秦丽娟, 孙三峰, 王娟. 补中益气法针刺联合经颅直流电刺激治疗中风后单侧空间忽略的临床疗效观察[J]. 辽宁中医杂志, 2025, 52(3): 174-177.
[58] Yanagisawa, T., Fukuma, R., Seymour, B., Tanaka, M., Yamashita, O., Hosomi, K., et al. (2022) Neurofeedback Training without Explicit Phantom Hand Movements and Hand-Like Visual Feedback to Modulate Pain: A Randomized Crossover Feasibility Trial. The Journal of Pain, 23, 2080-2091. [Google Scholar] [CrossRef] [PubMed]
[59] Yu, Z., Yang, X., Qin, F., Ma, T., Zhang, J., Leng, X., et al. (2023) Effects of Acupuncture Synchronized Rehabilitation Therapy on Upper Limb Motor and Sensory Function after Stroke: A Study Protocol for a Single-Center, 2 × 2 Factorial Design, Randomized Controlled Trial. Frontiers in Neurology, 14, Article 1162168. [Google Scholar] [CrossRef] [PubMed]
[60] Barelli, A., Valente, M.R., Clemente, A., Bozza, P., Proietti, R. and Corte, F.D. (1991) Serial Multimodality-Evoked Potentials in Severely Head-Injured Patients. Critical Care Medicine, 19, 1374-1381. [Google Scholar] [CrossRef] [PubMed]
[61] 杨世宁, 马将, 李红, 等. 不同病程脑卒中患者上肢体感诱发电位与感觉、运动功能的相关性[J]. 中国康复理论与实践, 2024, 30(6): 701-708.