中性粒细胞载脂蛋白与降钙素原对评估ICU脓毒症患者预后的诊断价值
Diagnostic Value of Human Neutrophil Lipoprotein and Procalcitonin in Assessing the Prognosis of Patients with Sepsis in ICU
DOI: 10.12677/acm.2026.1672688, PDF,   
作者: 赵泽昊：苏州大学附属第一医院急诊科，江苏 苏州
关键词: 脓毒症；中性粒细胞载脂蛋白；降钙素原；预后评价；Sepsis； Human Neutrophil Lipoprotein； Procalcitonin； Prognosis
摘要: 目的：探讨ICU脓毒症患者血清中性粒细胞载脂蛋白(HNL)和降钙素原(PCT)水平对预后的评估价值。方法：选取苏州大学附属第一医院2024年10月至2025年12月期间住院的36例脓毒症患者，根据住院30天内是否死亡将其分为生存组和死亡组，比较两组的血清HNL、PCT、WBC和CRP水平，并使用受试者工作特征曲线(ROC)分析血清HNL及PCT对ICU脓毒症患者预后的价值，同时选取28例健康体检人员作为本研究对照组，比较脓毒症组和对照组指标差异。结果：脓毒症组的血清HNL、PCT、WBC和CRP水平相比对照组显著升高(P < 0.05)，存活组的血清HNL和PCT水平低于死亡组(P < 0.05)，WBC及CRP则无统计学差异(P > 0.05)。结论：HNL、PCT、WBC及CRP等可用于脓毒症的诊断，HNL和PCT对鉴别ICU高危脓毒症患者诊断价值大。
Abstract: Objective: To explore the prognostic evaluation value of serum human neutrophil lipoprotein(HNL) and procalcitonin (PCT) levels in ICU patients with sepsis. Methods: A total of 36 sepsis patients admitted to the First Affiliated Hospital of Soochow University between October 2024 and December 2025 were enrolled in this study. These patients were categorized into a survival group and a death group based on their mortality status within 30 days of hospitalization. The serum levels of HNL, PCT, WBC, and CRP were compared between the two groups. The prognostic significance of serum HNL and PCT in ICU sepsis patients was evaluated using Receiver Operating Characteristic (ROC) curve analysis. Furthermore, 28 healthy individuals undergoing routine physical examinations were recruited as the control group to facilitate a comparative analysis of the aforementioned indicators between the sepsis and control groups. Results: The sepsis group exhibited significantly elevated serum levels of HNL, PCT, WBC, and CRP compared to the control group (P < 0.05). Within the sepsis cohort, the survival group demonstrated lower serum levels of HNL and PCT than the death group (P < 0.05), whereas no statistically significant differences were observed in WBC and CRP levels between the two groups (P > 0.05). Conclusion: HNL, PCT, WBC, and CRP serve as valuable diagnostic markers for sepsis, with HNL and PCT exhibiting substantial diagnostic utility in identifying high-risk sepsis patients in the ICU setting.
文章引用：赵泽昊. 中性粒细胞载脂蛋白与降钙素原对评估ICU脓毒症患者预后的诊断价值[J]. 临床医学进展, 2026, 16(7): 1666-1671. https://doi.org/10.12677/acm.2026.1672688

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