基于文献计量分析群体感应在颗粒污泥领域的应用
A Bibliometric Analysis of the Application of Quorum Sensing in the Field of Granular Sludge
DOI: 10.12677/aep.2026.167128, PDF,    科研立项经费支持
作者: 张世龙, 吕晶晶*, 芦珂毅, 梁曦殳, 窦艳艳, 李 扬, 陈旭东, 常步云：中原工学院智慧能源与环境学院，河南 郑州；殷秀海：中冶京诚工程技术有限公司，北京
关键词: 群体感应；颗粒污泥；文献计量分析；信号分子；污水处理；Quorum Sensing； Granular Sludge； Bibliometric Analysis； Signal Molecules； Wastewater Treatment
摘要: 为明确群体感应在颗粒污泥领域的研究现状与趋势，基于Web of Science核心合集183篇和中国知网246篇(2006年1月至2025年5月)的文献开展可视化分析。结果表明：发文量持续增长，2016年后显著加速。中国在WOS的发文量124篇(占总量的68%)，居全球首位，并与澳大利亚、加拿大等国形成紧密合作网络。研究热点集中于三方面：厌氧氨氧化中通过信号分子优化工艺提升脱氮效率；在好氧颗粒污泥中促进颗粒化并抑制解体，但关键机制待明；信号分子调控胞外聚合物(EPS)分泌促进细胞聚集的颗粒化协同机制。高频关键词与期刊分析表明，该领域研究正由机制认识向颗粒化调控、脱氮强化和稳定运行拓展；同时，中国学者已形成稳定团队并产出高影响力成果。未来需深化信号分子精准调控、群落协同演化机制及低能耗工艺开发。本研究为深入探索群体感应在颗粒污泥领域的研究和工程应用提供系统的文献计量学依据。
Abstract: To clarify the current status and trends in research on quorum sensing in the field of granular sludge, a visualization analysis was conducted based on 183 articles from the Web of Science Core Collection and 246 articles from China National Knowledge Infrastructure (CNKI) (January 2006 to May 2025). The results show that the number of publications has continued to grow, with a significant acceleration after 2016. China ranked first globally with 124 publications in the Web of Science (accounting for 68% of the total) and has formed a close collaborative network with countries such as Australia and Canada. Research hotspots are concentrated in three areas: optimizing processes through signaling molecules to enhance denitrification efficiency in anaerobic ammonium oxidation; promoting granulation and inhibiting disintegration in aerobic granular sludge, although the key mechanisms remain to be elucidated; the synergistic mechanism by which signaling molecules regulate extracellular polymeric substance (EPS) secretion to promote cell aggregation and granulation. Analysis of high-frequency keywords and journals indicates that research in this field is expanding from mechanistic understanding toward granulation regulation, denitrification enhancement, and stable operation; simultaneously, Chinese scholars have formed stable research teams and produced high-impact results. Future research should focus on deepening the understanding of precise regulation by signaling molecules, the mechanisms of community co-evolution, and the development of low-energy-consumption processes. This study provides a systematic bibliometric basis for further exploration of the research and engineering applications of quorum sensing in the field of granular sludge.
文章引用：张世龙, 殷秀海, 吕晶晶, 芦珂毅, 梁曦殳, 窦艳艳, 李扬, 陈旭东, 常步云. 基于文献计量分析群体感应在颗粒污泥领域的应用[J]. 环境保护前沿, 2026, 16(7): 1272-1284. https://doi.org/10.12677/aep.2026.167128

参考文献

[1] de Celis, M., Modin, O., Arregui, L., Persson, F., Santos, A., Belda, I., et al. (2024) Community Successional Patterns and Inter-Kingdom Interactions during Granular Biofilm Development. npj Biofilms and Microbiomes, 10, 109-112.
https://doi.org/10.1038/s41522-024-00581-x
[2] Shi, L., Li, R., Bu, Y., Wei, Y., Cai, W., Huang, Z., et al. (2023) Hybrid Granule-Floc Sludge Distribution and Its Potential for Upgrading a Tropical Continuous-Flow Wastewater Treatment Plant. Journal of Water Process Engineering, 55, Article 104178.
https://doi.org/10.1016/j.jwpe.2023.104178
[3] Wang, X., Yi, K., Pang, H., Liu, Z., Li, X., Zhang, W., et al. (2024) An Overview of Quorum Sensing in Shaping Activated Sludge Forms: Mechanisms, Applications and Challenges. Science of the Total Environment, 927, Article 171886.
https://doi.org/10.1016/j.scitotenv.2024.171886
[4] Gao, P., Li, J., Zhang, J., Zhao, A., Tang, P., Zhang, X., et al. (2024) Application and Mechanism of Quorum Sensing in Biological Wastewater Treatment Systems: Current State and Future Prospects. Journal of Environmental Chemical Engineering, 12, Article 113453.
https://doi.org/10.1016/j.jece.2024.113453
[5] 庞悦, 吴宗林, 安彤, 等. 污水生物处理中信号分子AHL介导的群体感应[J]. 水处理技术, 2020, 46(11): 1-15.
[6] 何航, 赵健, 孙宁, 等. 好氧颗粒膜生物污水处理技术研究进展[J]. 环境工程技术学报, 2021, 11(1): 163-172.
[7] Moreno-Gámez, S., Hochberg, M.E. and van Doorn, G.S. (2023) Quorum Sensing as a Mechanism to Harness the Wisdom of the Crowds. Nature Communications, 14, Article No. 3415.
https://doi.org/10.1038/s41467-023-37950-7
[8] 齐枝花, 于鑫, 余萍, 等. 生物法中细菌群感效应所需自诱导物的存在证明[J]. 中国给水排水, 2006(13): 18-21+25.
[9] Lv, Y., Huang, X. and Lee, D. (2024) The Second Messenger (Cyclic Diguanylate and Autoinducer-2) Promotes N-Acylated-Homoserine Lactones-Based Quorum Sensing for Enhanced Recovery of Stored Aerobic Granular Sludge. Bioresource Technology, 398, Article 130479.
https://doi.org/10.1016/j.biortech.2024.130479.
[10] Ji, Y.T., Yu, H.T., Cao, R.J., et al. (2022) Promoting the Granulation Process of Aerobic Sludge via a Sustainable Strategy of Effluent Reflux in View of AHLs-Mediated Quorum Sensing. Journal of Environmental Management, 303, Article 114091.
https://doi.org/10.1016/j.jenvman.2021.114091
[11] 杨早, 毛萍, 何奕忻, 等. 基于VOSviewer的公园城市计量特征、热点与趋势[J]. 应用与环境生物学报, 2022, 28(4): 84-93.
[12] 付全升, 黄先寒, 申仕康, 等. 基于数据库的植物功能性状研究现状文献计量学分析[J]. 应用与环境生物学报, 2021, 27(1): 228-240.
[13] Zheng, T.L., Li, P.Y., Wu, W.J., et al. (2018) State of the Art on Granular Sludge by Using Bibliometric Analysis. Applied Microbiology and Biotechnology, 102, 3453-3473.
https://doi.org/10.1007/s00253-018-8844-5
[14] 索传军, 于淼, 牌艳欣, 等. 数据驱动的学术评价理论框架研究[J]. 图书情报工作, 2024, 68(1): 5-12.
[15] Sarma, S.J., Tay, J.H. and Chu, A. (2017) Finding Knowledge Gaps in Aerobic Granulation Technology. Trends in Biotechnology, 35, 66-78.
https://doi.org/10.1016/j.tibtech.2016.07.003
[16] 李杰, 王少坡, 李亚静, 等. 好氧颗粒污泥污水处理技术研究现状与发展[J]. 环境科学与技术, 2021, 44(11): 176-183.
[17] 刘莎莎, 梁家豪, 李晋, 等. 信号分子在好氧污泥颗粒化中的作用及其控制策略[J]. 工业水处理, 2021, 41(1): 25-29.
[18] 赵敏娟, 李雨季, 王佳彤, 等. 好氧颗粒污泥处理低C/N生活污水的新策略探究[J]. 水处理技术, 2021, 47(12): 112-115+119.
[19] Zhao, R., Zhang, X., Jin, D., Zhu, X., Ji, L., Gao, B., et al. (2025) Anammox Sludge Granulation and Synergy with Comammox: A Critical Review. Journal of Environmental Chemical Engineering, 13, Article 115300.
https://doi.org/10.1016/j.jece.2024.115300
[20] 曹宇浩, 管锡珺, 陈计洋, 等. 不同粒径厌氧颗粒污泥产气作用对沉降性能的影响[J]. 中国给水排水, 2024, 40(5): 82-86.
[21] 肖飞, 杨紫海, 王世民, 等. 优化双搅拌策略修复耐盐好氧颗粒污泥脱氮除磷及结构稳定性研究[J]. 水处理技术, 2025, 51(4): 92-98+112.
[22] Zhang, X.N., Zhu, Z.X., Zhang, X.X., et al. (2025) Deciphering Intricate Associations between Vigorous Development and Novel Metabolic Preferences of Partial Denitrification/Anammox Granular Consortia within Mainstream Municipal Wastewater. Bioresource Technology, 419, Article 132074.
https://doi.org/10.1016/j.biortech.2025.132074
[23] Gao, M.J., Zou, X., Dang, H.Y., et al. (2024) Enhancing Anammox Process at Moderate Temperature via Employing Anammox Granular Sludge Reactor Effluent Addition. Process Safety and Environmental Protection, 182, 894-902.
https://doi.org/10.1016/j.psep.2023.12.014
[24] 王亚军, 秦楚桐, 李肇隆, 等. 好氧颗粒污泥结构稳定强化策略研究评述[J]. 生态环境学报, 2024, 33(3): 478-486.
[25] Jang, E., Min, K.J., Lee, E., Choi, H. and Park, K.Y. (2023) Acceleration of Aerobic Granulation in Sidestream Treatment with Exogenous Autoinducer. Water, 15, Article 2173.
https://doi.org/10.3390/w15122173
[26] 明婕, 黄子萌, 董清林, 等. 好氧颗粒污泥的性质及形成机制[J]. 水处理技术, 2019, 45(7): 1-5+23.
[27] 赵生娟, 刘莎莎, 宋佳宇, 等. 颗粒污泥中群体感应的环境影响因素及其对EPS的调控机制[J]. 工业水处理, 2025, 45(11): 8-18.
[28] Xiong, F.Z., Zhao, X.X., Wen, D.H., et al. (2020) Effects of N-Acyl-Homoserine Lactones-Based Quorum Sensing on Biofilm Formation, Sludge Characteristics, and Bacterial Community during the Start-Up of Bioaugmented Reactors. Science of the Total Environment, 735, Article 139449.
https://doi.org/10.1016/j.scitotenv.2020.139449
[29] 谭煜, 付丽亚, 周鉴, 等. 胞外聚合物(EPS)对污水处理影响的研究进展[J]. 环境工程技术学报, 2021, 11(2): 307-313.
[30] 唐婧, 李威潭, 杨佳豪. 基于CiteSpace的污水处理厂生命周期碳排放评价领域研究热点[J]. 应用与环境生物学报, 2024, 30(3): 633-641.
[31] 徐佳杰, 张妮, 谢周云, 等. 好氧颗粒污泥耐受PFOS的结构稳定性及微生物响应[J]. 中国环境科学, 2022, 42(11): 5117-5127.
[32] Li, T.L., Guo, F., Lin, Y., et al. (2019) Metagenomic Analysis of Quorum Sensing Systems in Activated Sludge and Membrane Biofilm of a Full-Scale Membrane Bioreactor. Journal of Water Process Engineering, 32, Article 100952.
https://doi.org/10.1016/j.jwpe.2019.100952
[33] Perianes-Rodriguez, A., Waltman, L. and van Eck, N.J. (2016) Constructing Bibliometric Networks: A Comparison between Full and Fractional Counting. Journal of Informetrics, 10, 1178-1195.
https://doi.org/10.1016/j.joi.2016.10.006
[34] 王洪臣. 坚持和发展中国特色城市治水路线[J]. 给水排水, 2025, 61(1): 1-12.
[35] Li, Y.S., Li, B.B., Tian, T., et al. (2023) Quorum Sensing Unveils the Sludge Floccule‐Assisted Stabilization of Aerobic Granules in Granule‐Dominated Sequencing Batch Reactors. Biotechnology and Bioengineering, 120, 444-455.
https://doi.org/10.1002/bit.28275
[36] 卢之琪, 唐俊, 李洪静. 污水生物处理领域“群体感应”应用研究进展[J]. 复旦学报(自然科学版), 2024, 63(3): 306-319.
[37] Guan, W. and Ling, W. (2020) Analysis of Visual Knowledge Mapping of Digital Twin Research Based on Bibliometrics. Computer Integrated Manufacturing Systems, 26, 18-27.
[38] 支丽玲, 王玉莹, 马鑫欣, 等. c-di-GMP在低温好氧颗粒污泥形成过程中的作用[J]. 中国环境科学, 2019, 39(4): 1560-1577.
[39] 汤皓婷, 隆静, 蒋宽胜, 等. 好氧颗粒污泥失稳机理及改善策略之研究进展[J]. 环境工程, 2023, 41(9): 96-106.
[40] 刘文如, 阴方芳, 丁玲玲, 等. 选择性排泥改善颗粒污泥亚硝化性能的研究[J]. 中国环境科学, 2014, 34(2): 396-402.
[41] de Solla Price, D.J. (1963) Little Science, Big Science. Columbia University Press.
[42] 文丹, 李蕾, 史昱翔, 等. 机械力化学在环境领域的研究及应用: 基于球磨方法的文献计量分析[J]. 应用化工, 2025, 54(2): 439-445+451.
[43] Shi, Y.H., Huang, J.H., Zeng, G.M., et al. (2017) Exploiting Extracellular Polymeric Substances (EPS) Controlling Strategies for Performance Enhancement of Biological Wastewater Treatments: An Overview. Chemosphere, 180, 396-411.
https://doi.org/10.1016/j.chemosphere.2017.04.042
[44] Tan, C.H., Koh, K.S., Xie, C., et al. (2014) The Role of Quorum Sensing Signalling in EPS Production and the Assembly of a Sludge Community into Aerobic Granules. The ISME Journal, 8, 1186-1197.
https://doi.org/10.1038/ismej.2013.240