含氮杂环4-羟基哌啶的官能化反应研究
Study on the Functionalization Reaction of Nitrogen-Containing Heterocyclic 4-Hydroxypiperidine
DOI: 10.12677/hjcet.2026.164031, PDF,    科研立项经费支持
作者: 蔡彦鹏, 张立硕, 张天昶, 苏文嘉艺, 马 乾, 王翠苹*：辽宁科技大学化学工程学院，辽宁 鞍山
关键词: 哌啶；有机中间体；C-O键；杂环；官能化；Piperidine； Organic Intermediate； C-O Bond； Heterocycle； Functionalization
摘要: 哌啶是一种非芳香性饱和六元含氮杂环化合物，也是一类重要的含氮杂环类有机中间体，具有良好的生物活性，在医药、农药等领域得到了广泛应用。文章以含氮杂环N-Boc-4-羟基哌啶和溴代芳烃为原料，在溶剂和碱存在的条件下，不添加任何金属催化剂，经C-O键的官能化反应合成了四种1-Boc-4-芳氧基哌啶衍生物，并对其结构进行了NMR和MS表征。该方法具有很好的底物兼容性。
Abstract: Piperidine is a non-aromatic, saturated six-membered nitrogen-containing heterocyclic compound. As a vital nitrogen-heterocyclic organic intermediate with favorable biological activities, it has been widely applied in pharmaceuticals, pesticides, and other fields. In this paper, four 1-Boc-4-aryloxypiperidine derivatives were synthesized via C-O bond functionalization reactions using N-Boc-4-hydroxypiperidine and aryl bromides as starting materials under solvent and base conditions without any metal catalyst. Their structures were characterized by NMR and MS spectroscopy. This method exhibits excellent substrate compatibility.
文章引用：蔡彦鹏, 张立硕, 张天昶, 苏文嘉艺, 马乾, 王翠苹. 含氮杂环4-羟基哌啶的官能化反应研究[J]. 化学工程与技术, 2026, 16(4): 330-335. https://doi.org/10.12677/hjcet.2026.164031

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