羟考酮在临床麻醉中的应用进展
Advances in the Clinical Application of Oxycodone in Anesthesia
DOI: 10.12677/acm.2026.1682768, PDF,   
作者: 徐林波：右江民族医学院研究生院，广西 百色；韦巧松*：右江民族医学院附属西南医院麻醉科，广西 百色
关键词: 羟考酮；临床麻醉；多模式镇痛；应激反应；寒战防治；Oxycodone； Clinical Anesthesia； Multimodal Analgesia； Stress Response； Shivering Prevention
摘要: 羟考酮是μ和κ双受体激动剂，在临床麻醉中具有重要价值。本文结合近五年国内外相关文献，从多模式镇痛、特殊手术类型、并发症防治及药物联合应用等方面进行综述。研究表明，羟考酮血流动力学稳定，老年患者不良反应少，在内脏痛控制、超前镇痛与寒战防治方面有效，与局麻药物联用有协同效应，还可通过κ受体介导的抗炎作用参与炎症调节。未来需进一步探索CYP2D6基因多态性指导个体化用药，探究羟考酮的剂量–效应关系，推动羟考酮科学、规范的应用。
Abstract: Oxycodone, a dual μ- and κ-opioid receptor agonist, plays an important role in clinical anesthesia. This review synthesizes relevant national and international literature published over the past five years, focusing on multimodal analgesia, specific surgical procedures, complication management, and drug combinations. Current evidence indicates that oxycodone provides hemodynamic stability and a favorable safety profile in elderly patients, with demonstrated efficacy in visceral pain control, preemptive analgesia, and shivering prevention. It also shows synergistic effects when combined with local anesthetics and may modulate inflammatory responses via κ-receptor-mediated pathways. Future research should further investigate the role of CYP2D6 pharmacogenomics in guiding individualized dosing, as well as the precise dose-response relationship of oxycodone, to promote its safe, effective, and evidence-based integration into perioperative clinical practice.
文章引用：徐林波, 韦巧松. 羟考酮在临床麻醉中的应用进展[J]. 临床医学进展, 2026, 16(8): 30-38. https://doi.org/10.12677/acm.2026.1682768

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