马齿苋白鲜皮外敷干预炎性毛孔粗大研究
External Application of Portulaca and Dictamnus for Inflammatory Enlarged Pores
DOI: 10.12677/jcpm.2026.54219, PDF,    科研立项经费支持
作者: 汪晓宇, 孟禹辰：黑龙江中医药大学第一临床医学院，黑龙江 哈尔滨；刘传奇：黑龙江中医药大学第二临床医学院，黑龙江 哈尔滨；刘 洋*：黑龙江中医药大学基础医学院，黑龙江 哈尔滨
关键词: 马齿苋；白鲜皮；炎性毛孔粗大；外敷；作用机制；临床疗效；Portulaca Oleracea； Dictamnus Cortex； Inflammatory Enlarged Pores； External Application； Mechanism； Clinical Efficacy
摘要: 炎性毛孔粗大以毛囊皮脂腺单位炎症激活、角化异常、皮脂分泌增多及毛囊周围支持结构受损为主要病理基础，临床表现为毛孔扩张、红斑、角栓形成及肤质粗糙。现有缩孔治疗多偏重控油、剥脱或光电重塑，虽可短期改善外观，但在复发控制、炎症调节及屏障保护方面仍存在不足。马齿苋与白鲜皮均属皮肤科外治常用中药，现代研究提示其具有抗炎、抑菌、抗氧化、调节免疫及促进皮肤屏障修复等作用。本文围绕炎性毛孔粗大的发病特点，综述马齿苋–白鲜皮外敷的药理基础、可能作用机制及相关临床研究进展。现有证据表明，两药可能通过抑制炎症信号通路、调节毛囊皮脂腺微环境、改善角质代谢与屏障功能等多途径发挥作用，并可为炎性毛孔粗大的中药外治研究提供思路。然而目前直接针对该病证的高质量临床证据仍然不足，后续尚需结合规范化基础实验、随机对照研究及客观量化评价体系，进一步明确其有效成分、作用靶点及临床适用性。
Abstract: Inflammatory enlarged pores are associated with inflammation of the pilosebaceous unit, abnormal keratinization, excessive sebum secretion, and damage to perifollicular supporting structures. Current treatments mainly focus on oil control, keratolysis, or energy-based remodeling and can provide temporary cosmetic improvement, but limitations remain in recurrence prevention, inflammatory regulation, and barrier protection. Portulaca oleracea and Dictamnus Cortex are commonly used topical herbs in dermatologic practice, and recent studies suggest anti-inflammatory, antimicrobial, antioxidant, immunomodulatory, and skin barrier-repair effects. This article reviews the pharmacological basis, potential mechanisms, and relevant clinical evidence of external application of these two herbs in inflammatory enlarged pores. Available evidence indicates that they may improve the disease through suppression of inflammatory pathways, regulation of the pilosebaceous microenvironment, and restoration of keratinization and barrier function. However, direct high-quality evidence remains insufficient, and further standardized basic research and randomized clinical trials are warranted.
文章引用：汪晓宇, 孟禹辰, 刘传奇, 刘洋. 马齿苋白鲜皮外敷干预炎性毛孔粗大研究[J]. 临床个性化医学, 2026, 5(4): 11-19. https://doi.org/10.12677/jcpm.2026.54219

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