肝硬化与幽门螺旋杆菌的相关性研究
Study on the Correlation between Liver Cirrhosis and Helicobacter pylori
DOI: 10.12677/acm.2026.1682773, PDF,   
作者: 宋 慧*：青岛大学青岛医学院，山东 青岛；淄博市传染病医院感染科，山东 淄博；牛庆慧#：青岛大学附属医院肝病内科，山东 青岛
关键词: 肝硬化；幽门螺旋杆菌；乙型病毒性肝炎；感染；Liver Cirrhosis； Helicobacter pylori； Hepatitis B Virus Infection； Infection
摘要: 目的：探讨肝硬化患者与幽门螺旋杆菌(Helicobacter pylori, HP)的感染率及相关性。方法：选取2023年1月~2025年12月期间首次确诊为肝硬化患者的70例，应用检测尿素13C呼气试验检测肝硬化患者的HP，分析HP的感染率与HBsAg、临床分期、肝功能Child-Pugh分级的关系，探讨HP检测值与乙肝DNA定量、肝硬度测定值(LSM)的相关性。结果：HP的感染率与患者年龄与性别无统计学差异。肝硬化患者HP阳性率(65.71%)显著高于密切接触者(47.14%)；HBsAg阳性的HP感染率(78.05%)明显高于阴性(48.27%)；失代偿期的HP感染率(75.00%)高于代偿期(57.89%)；HP阳性率呈现出随着级数从Child-Pugh分级A到C依次升高；以上均有统计学差异(P < 0.05)。HP检测值与HBV-DNA定量、LSM均呈正相关，有统计学差异(P < 0.05)。结论：肝硬化患者HP的感染率较高，HP可能在肝硬化的发生、发展中有一定程度的协同作用。
Abstract: Objective: To investigate the infection rate of Helicobacter pylori (HP) in patients with liver cirrhosis and its correlation. Methods: A total of 70 patients newly diagnosed with liver cirrhosis from Janu-ary 2023 to December 2025 were enrolled. The 13C urea breath test was used to detect HP infection in cirrhotic patients. The relationships between HP infection rate and HBsAg, clinical stage, and Child-Pugh grade of liver function were analyzed. The correlations between HP test value and hepa-titis B virus DNA quantification, as well as liver stiffness measurement (LSM), were explored. Re-sults: No statistically significant differences in HP infection rate were observed with respect to pa-tient age or gender. The HP positive rate in cirrhotic patients (65.71%) was significantly higher than that in close contacts (47.14%). The HP infection rate in HBsAg-positive patients (78.05%) was significantly higher than that in HBsAg-negative patients (48.27%). The HP infection rate in the de-compensated stage (75.00%) was higher than that in the compensated stage (57.89%). The HP pos-itive rate increased progressively from Child-Pugh grade A to C. All the above differences were sta-tistically significant (P < 0.05). The HP test value was positively correlated with HBV-DNA quantifi-cation and LSM, with statistical significance (P < 0.05). Conclusion: The infection rate of HP is high in patients with liver cirrhosis. HP may play a synergistic role in the occurrence and development of liver cirrhosis to some extent.
文章引用：宋慧, 牛庆慧. 肝硬化与幽门螺旋杆菌的相关性研究[J]. 临床医学进展, 2026, 16(8): 71-78. https://doi.org/10.12677/acm.2026.1682773

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