关于五指毛桃治疗酒精性肝炎的研究综述

A Review of Studies on Ficus hirta in the Treatment of Alcoholic Hepatitis

摘要: 酒精性肝炎是酒精性肝病的重要阶段，其临床治疗手段相对有限。五指毛桃作为传统中药，其醇提取物在多项研究中表现出抗氧化、抗炎及肝保护活性。本文系统综述了近年来关于五指毛桃醇提取物干预酒精性肝炎的实验研究进展，涵盖其对肝细胞损伤的缓解作用、氧化应激水平的调节、炎症反应的抑制及可能的分子机制。现有证据表明，该提取物可通过多靶点协同发挥保肝效应，具有成为酒精性肝炎辅助治疗药物的潜力。本文旨在总结现有成果，分析不足，并展望未来研究方向。

Abstract: Alcoholic hepatitis is a critical stage of alcoholic liver disease, with relatively limited clinical treatment options. Ficus hirta, a traditional Chinese medicine, has demonstrated antioxidant, anti‑inflammatory, and hepatoprotective activities in multiple studies using its alcohol extract. This article systematically reviews recent experimental research on the intervention of Ficus hirta alcohol extract in alcoholic hepatitis, covering its alleviation of hepatocyte injury, regulation of oxidative stress levels, suppression of inflammatory responses, and possible molecular mechanisms. Current evidence indicates that the extract exerts hepatoprotective effects through multi‑target synergy, showing potential as an adjunctive therapeutic agent for alcoholic hepatitis. This review aims to summarize existing findings, analyze shortcomings, and propose future research directions.