血栓闭塞性脉管炎与生活习惯的关联性分析
Analysis of the Association between Thromboangiitis Obliterans and Lifestyle Habits Ulcers
DOI: 10.12677/acm.2026.1682829, PDF,   
作者: 刘徐超*:黑龙江中医药大学研究生院,黑龙江 哈尔滨;孙 秋#:黑龙江中医药大学附属第一医院周围血管病一科,黑龙江 哈尔滨
关键词: 血栓闭塞性脉管炎;生活习惯;危险因素;关联性;Thromboangiitis Obliterans; Lifestyle Habits; Risk Factors; Correlation
摘要: 血栓闭塞性脉管炎是一种以中小动脉和静脉节段性、闭塞性炎症为特征的慢性血管疾病,临床表现为肢体远端缺血、疼痛、麻木、溃疡甚至坏疽。目前TAO的病因尚未完全明确,研究证实其发病是遗传易感性、外界环境因素及生活习惯共同作用的结果,其中不良生活习惯作为可干预的危险因素,与疾病的发生、发展、预后密切相关。本文结合近年来国内外相关研究进展,深入分析吸烟、饮食结构、运动久坐等常见生活方式与TAO的流行病学关联证据,总结干预要点,为TAO的预防、临床诊疗及远期康复提供相关理论依据和实践参考。
Abstract: Thromboangiitis obliterans (TAO) is a chronic vascular disease characterized by segmental, occlusive inflammation of small and medium-sized arteries and veins, clinically manifested as distal limb ischemia, pain, numbness, ulcers, and even gangrene. The etiology of TAO remains incompletely understood, with studies confirming that its pathogenesis results from the combined effects of genetic predisposition, external environmental factors, and lifestyle habits. Among these, unhealthy lifestyle habits, as modifiable risk factors, are closely associated with the occurrence, progression, and prognosis of the disease. This article synthesizes recent domestic and international research advances to thoroughly analyze epidemiological evidence linking common lifestyle factors—such as smoking, dietary patterns, and physical inactivity—with TAO, summarizing key intervention points to provide theoretical foundations and practical references for TAO prevention, clinical diagnosis, treatment, and long-term rehabilitation.
文章引用:刘徐超, 孙秋. 血栓闭塞性脉管炎与生活习惯的关联性分析[J]. 临床医学进展, 2026, 16(8): 585-591. https://doi.org/10.12677/acm.2026.1682829

参考文献

[1] Matsushita, M., Nishikimi, N., Sakurai, T. and Nimura, Y. (1998) Decrease in Prevalence of Buerger’s Disease in Japan. Surgery, 124, 498-502.
https://doi.org/10.1016/s0039-6060(98)70095-9
[2] 王嘉桔, 赵文光, 王征. 我国血栓闭塞性脉管炎流行病学调查研究[J]. 中华国际医药杂志, 2002, 1(1): 45-47.
[3] Reny, J.L. and Cabane, J. (1998) La maladie de Buerger ou thromboangéte oblitérante. La Revue de Médecine Interne, 19, 34-43.
https://doi.org/10.1016/s0248-8663(97)83697-1
[4] Sharebiani, H., Fazeli, B., Maniscalco, R., Ligi, D. and Mannello, F. (2020) The Imbalance among Oxidative Biomarkers and Antioxidant Defense Systems in Thromboangiitis Obliterans (Winiwarter-Buerger Disease). Journal of Clinical Medicine, 9, Article 1036.
https://doi.org/10.3390/jcm9041036
[5] Modaghegh, M.S., Kazemzadeh, G.H., Ravari, H., Johari, H.G. and Barzanuni, A. (2015) Buerger’s Disease in the Northeast of Iran: Epidemiology and Clinical Features. Vascular, 23, 519-524.
https://doi.org/10.1177/1708538114552838
[6] 金星, 王茂华, 吴学君, 等. 吸烟与大鼠血栓闭塞性脉管炎的关系探讨[J]. 山东医药, 2011, 51(6): 29-30.
[7] Vicente, I., Alves, A., Pereira, A. and Roncon de Albuquerque, R. (2012) Avaliação das alterações hemodinâmicas em pacientes com diagnóstico de doença de buerger. Acta Médica Portuguesa, 25, 156-164.
https://doi.org/10.20344/amp.36
[8] Jiménez-Ruiz, C.A., Dale, L.C., Astray Mochales, J., Velázquez Buendía, L., De Granda Orive, I. and Guirao García, A. (2016) Smoking Characteristics and Cessation in Patients with Thromboangiitis Obliterans. Monaldi Archives for Chest Disease, 65, 217-221.
https://doi.org/10.4081/monaldi.2006.552
[9] Highlander, P., Southerland, C.C., VonHerbulis, E. and Gonzalez, A. (2011) Buerger Disease (Thromboangiitis obliterans): A Clinical Diagnosis. Advances in Skin & Wound Care, 24, 15-17.
https://doi.org/10.1097/01.asw.0000392923.37852.43
[10] 花奇凯, 高伟. 血栓闭塞性脉管炎的诊疗现状与应用前景[J]. 微创医学, 2016, 11(4): 551-553.
[11] 舒小军, 李正飞, 王平, 等. 血栓闭塞性脉管炎的病因学和发病机制的研究[J]. 山西医药杂志(下半月版), 2013, 42(6): 280-282.
[12] Stammler, F. and Diehm, C. (1995) Rauchen und periphere Gefässleiden. Zeitschrift für Ärztliche Fortbildung, 89, 459-466.
[13] Phang, M., Lazarus, S., Wood, L. and Garg, M. (2011) Diet and Thrombosis Risk: Nutrients for Prevention of Thrombotic Disease. Seminars in Thrombosis and Hemostasis, 37, 199-208.
https://doi.org/10.1055/s-0031-1273084
[14] Olin, J.W. (2018) Thromboangiitis Obliterans: 110 Years Old and Little Progress Made. Journal of the American Heart Association, 7, e011214.
https://doi.org/10.1161/jaha.118.011214
[15] 付书贞, 王园园. 25-羟基维生素D3在血栓闭塞性脉管炎外周血的表达及其与脑动脉损害的关系[J]. 中国保健营养, 2016, 26(25): 296-296.
[16] Ojaroodi, A.F., Jafarnezhad, F., Eskandari, Z., Keramat, S. and Stanek, A. (2024) Recent Updates and Advances in the Association between Vitamin D Deficiency and Risk of Thrombotic Disease. Nutrients, 17, Article 90.
https://doi.org/10.3390/nu17010090
[17] Xu, T., Zhu, G. and Han, S. (2020) Prevalence of Suboptimal Health Status and the Relationships between Suboptimal Health Status and Lifestyle Factors among Chinese Adults Using a Multi-Level Generalized Estimating Equation Model. International Journal of Environmental Research and Public Health, 17, Article 763.
https://doi.org/10.3390/ijerph17030763
[18] Thijssen, D.H.J., Maiorana, A.J., O’Driscoll, G., Cable, N.T., Hopman, M.T.E. and Green, D.J. (2010) Impact of Inactivity and Exercise on the Vasculature in Humans. European Journal of Applied Physiology, 108, 845-875.
https://doi.org/10.1007/s00421-009-1260-x
[19] Green, D.J. and Smith, K.J. (2018) Effects of Exercise on Vascular Function, Structure, and Health in Humans. Cold Spring Harbor Perspectives in Medicine, 8, a029819.
https://doi.org/10.1101/cshperspect.a029819
[20] Königstein, K., Dipla, K. and Zafeiridis, A. (2023) Training the Vessels: Molecular and Clinical Effects of Exercise on Vascular Health—A Narrative Review. Cells, 12, Article 2544.
https://doi.org/10.3390/cells12212544
[21] Whyte, J.J. and Harold Laughlin, M. (2010) The Effects of Acute and Chronic Exercise on the Vasculature. Acta Physiologica, 199, 441-450.
https://doi.org/10.1111/j.1748-1716.2010.02127.x
[22] McDermott, M.M. (2017) Exercise Training for Intermittent Claudication. Journal of Vascular Surgery, 66, 1612-1620.
https://doi.org/10.1016/j.jvs.2017.05.111
[23] 谭逢梅, 李文华. 步行锻炼对血栓闭塞性脉管炎患者PTA术后患肢侧支循环的影响[J]. 医学信息, 2020, 33(23): 177-178.
[24] Klein-Weigel, P., Volz, T.S., Zange, L. and Richter, J. (2016) Buerger’s Disease: Providing Integrated Care. Journal of Multidisciplinary Healthcare, 9, 511-518.
https://doi.org/10.2147/jmdh.s109985
[25] Khati, I., Menvielle, G., Chollet, A., Younès, N., Metadieu, B. and Melchior, M. (2015) What Distinguishes Successful from Unsuccessful Tobacco Smoking Cessation? Data from a Study of Young Adults (Tempo). Preventive Medicine Reports, 2, 679-685.
https://doi.org/10.1016/j.pmedr.2015.08.006
[26] Balmford, J., Leifert, J.A., Schulz, C., Elze, M. and Jaehne, A. (2014) Implementation and Effectiveness of a Hospital Smoking Cessation Service in Germany. Patient Education and Counseling, 94, 103-109.
https://doi.org/10.1016/j.pec.2013.09.024
[27] 朱洪江. 血栓闭塞性脉管炎的治疗进展[J]. 医学理论与实践, 2019, 32(6): 806-807, 813.
[28] 袁又圆. 自我管理教育在介入治疗血栓闭塞性脉管炎护理的探索[J]. 血管与腔内血管外科杂志, 2017, 3(6): 1101-1103+1105.
[29] 宋倩倩, 王克芳. 健康教育对血栓闭塞性脉管炎患者行为方式的影响[J]. 求医问药(下半月刊), 2012, 10(8): 647-648.