用于光气检测的荧光探针的研究进展
Research Progress on Fluorescent Probes for Phosgene Detection
DOI: 10.12677/japc.2026.153020, PDF,    科研立项经费支持
作者: 孟 瓒, 王 晔, 张悦然, 李咨诺, 高 云, 高 妍*：辽宁科技大学化学工程学院，辽宁 鞍山
关键词: 光气；荧光探针；识别机制；可视化检测；Phosgene； Fluorescent Probe； Recognition Mechanism； Visual Detection
摘要: 光气(COCl2)作为一种高毒性、高反应活性的窒息性化学战剂及重要化工中间体，广泛应用于聚碳酸酯、农药和医药合成等领域。然而，其极低的致死浓度和隐蔽性强、潜伏期短等特点，使其在生产、储存与运输过程中会造成严峻的急性中毒风险，因此开发快速、灵敏且可视化的光气检测方法已成为保障工业安全与公共健康的重大现实需求。在此背景下，小分子有机荧光探针因其低检测限、快速响应动力学和优异的选择特异性，正迅速成为光气传感领域的前沿策略。本文系统梳理了基于不同识别机制的小分子荧光探针的研究进展，重点评述其响应机理、光物理性能及结构–性能构效关系，旨在为面向复杂环境与生物体系的高性能光气荧光探针的设计提供系统性理论支撑。
Abstract: Phosgene (COCl2) is a highly toxic and chemically reactive choking chemical warfare agent, as well as an essential chemical intermediate widely applied in the synthesis of polycarbonates, pesticides and pharmaceuticals. Nevertheless, characterized by an extremely low lethal concentration, strong concealment and a short incubation period, phosgene poses a severe risk of acute poisoning during its production, storage and transportation. Therefore, the development of rapid and sensitive phosgene detection methods has become an urgent practical demand for industrial safety and public health protection. Against this background, small-molecule organic fluorescent probes have rapidly emerged as a cutting-edge strategy in the field of phosgene sensing due to their inherent advantages such as low detection limit, fast response kinetics and excellent selectivity. This paper systematically reviews the research progress of small-molecule fluorescent probes based on different recognition mechanisms, with a focus on their response mechanisms, photophysical properties and structure-performance relationships. It aims to provide systematic theoretical support for the rational design of high-performance phosgene fluorescent probes suitable for complex environmental and biological systems.
文章引用：孟瓒, 王晔, 张悦然, 李咨诺, 高云, 高妍. 用于光气检测的荧光探针的研究进展[J]. 物理化学进展, 2026, 15(3): 202-214. https://doi.org/10.12677/japc.2026.153020

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