前列腺癌伴胸膜转移1例
Prostate Cancer with Pleural Metastasis: A Case Report
DOI: 10.12677/jcpm.2026.54239, PDF,   
作者: 宋金瑶:济宁医学院临床医学院,山东 济宁;王全义*:济宁医学院附属医院病理科,山东 济宁
关键词: 前列腺癌胸膜结节胸腔积液转移 Prostate Cancer Pleural Nodule Pleural Effusion Metastasis
摘要: 前列腺癌伴胸膜转移是极为少见的,且整体预后较差,做到早发现早治疗尤为重要。本文报道1例因发现胸腔积液入院的61岁男性患者,入院检查提示血清总前列腺特异性抗原显著升高,影像学检查发现胸膜结节性病变,经胸膜活检及免疫组织化学检测提示前列腺来源,最终结合前列腺MRI确诊前列腺癌伴胸膜转移、恶性胸腔积液。后续患者接受内分泌治疗联合化疗,目前病情稳定。
Abstract: Pleural metastasis from prostate cancer is extremely rare and is associated with a poor overall prognosis, therefore, early detection and treatment are of paramount importance. This case report describes a 61-year-old male who presented with pleural effusion. Laboratory tests revealed markedly elevated serum total prostate-specific antigen. Imaging demonstrated nodular pleural lesions. Pleural biopsy with immunohistochemical staining confirmed prostatic origin, and subsequent prostate MRI established the diagnosis of metastatic prostate cancer with pleural involvement and malignant pleural effusion. The patient was treated with combined endocrine therapy and chemotherapy, and currently remains in stable condition.
文章引用:宋金瑶, 王全义. 前列腺癌伴胸膜转移1例[J]. 临床个性化医学, 2026, 5(4): 190-194. https://doi.org/10.12677/jcpm.2026.54239

参考文献

[1] Bray, F., Laversanne, M., Sung, H., Ferlay, J., Siegel, R.L., Soerjomataram, I., et al. (2024) Global Cancer Statistics 2022: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 74, 229-263.
https://doi.org/10.3322/caac.21834
[2] Skrobisz, K., Miszewski, K., Miszewska, L., Bieńkowski, M., Matuszewski, M. and Studniarek, M. (2025) Pleural Metastasis as an Initial Presentation of Prostate Cancer: Case Report and Literature Review. Diagnostics, 15, Article 666.
https://doi.org/10.3390/diagnostics15060666
[3] Jamil, A., Ali, R., Paige, A., Miller, R., Mistry, N., Abbas, A., et al. (2024) Atypical Pulmonary Metastasis of Prostate Adenocarcinoma: A Rare Phenomenon. European Journal of Case Reports in Internal Medicine, 11, Article ID: 004494.
https://doi.org/10.12890/2024_004494
[4] Knight, J.C., Ray, M.A. and Benzaquen, S. (2014) Malignant Pleural Effusion from Prostate Adenocarcinoma. Respiratory Medicine Case Reports, 13, 24-25.
https://doi.org/10.1016/j.rmcr.2014.04.001
[5] Sampsonas, F., Komninos, D., Sotiropoulou, V., Katsaras, M., Gkanetsou, D., Papaioannou, O., et al. (2024) EBUS-TBNA Pleural Biopsy Reveals Prostate Cancer Metastasis: A Rare Case Report and Review of the Literature. Pneumon, 37, 1-4.
https://doi.org/10.18332/pne/188870
[6] So, M., Chaddha, U., Shojaee, S. and Lee, P. (2023) Medical Thoracoscopy for Pleural Diseases. Current Opinion in Pulmonary Medicine, 30, 84-91.
https://doi.org/10.1097/mcp.0000000000001039
[7] Prihadi, J.C., Lionardi, S.K., Widjanarko, N.D., Alvianto, S., Rinaldi, F.X. and Iskandar, A.F. (2025) AMACR Is a Highly Sensitive and Specific Immunohistochemical Marker for Diagnosing Prostate Cancer on Biopsy: A Systematic Review and Meta-Analysis. Journal of Pathology and Translational Medicine, 59, 235-248.
https://doi.org/10.4132/jptm.2025.04.16
[8] Wang, M., Abi-Raad, R., Adeniran, A.J. and Cai, G. (2021) Expression of NKX3.1, Prostatic Specific Antigen and Prostatic Specific Alkaline Phosphatase in Cytology Specimens of Metastatic Prostatic Carcinoma. Journal of Clinical and Translational Pathology, 1, 16-20.
[9] Vakil, A., Upadhyay, H., Sherani, K., Cervellione, K. and Babury, M. (2014) Isolated Pleural Involvement in Recurrent Metastatic Prostate Cancer: A Case Report. Chest, 145, 308A.
https://doi.org/10.1378/chest.1826362
[10] Yasuda, K., Maeda, A., Yukawa, T., Saisho, S., Okita, R., Hirami, Y., et al. (2013) Case of Pleural Metastasis of Prostate Cancer. Thoracic Cancer, 4, 465-468.
https://doi.org/10.1111/1759-7714.12001
[11] Kawahara, T., Taguchi, H., Yamagishi, T., Udagawa, K., Ouchi, H. and Misaki, H. (2009) A Case of Bilateral Adrenal and Pleural Metastases from Prostate Cancer. Case Reports in Oncology, 2, 217-219.
https://doi.org/10.1159/000258964
[12] dos Santos, V.M., Zembrzuski, M.M., Gouvea, I.P., Nery, N.S. and dos Santos, L.A. (2011) Massive Pleural Effusion Due to Metastasis of Prostate Cancer. The West Indian Medical Journal, 60, 690-693.
[13] Singh, S. and Singh, A. (2013) Metastasis of Prostate Cancer to Pleura. Journal of Pulmonary & Respiratory Medicine, 3, Article ID: 1000135.
https://doi.org/10.4172/2161-105x.1000135
[14] Ahmed, M.E., Mahmoud, A.M., Reitano, G., Zeina, W., Lehner, K., Day, C.A., et al. (2024) Survival Patterns Based on First-Site-Specific Visceral Metastatic Prostate Cancer: Are Outcomes of Visceral Metastases the Same? European Urology Open Science, 66, 38-45.
https://doi.org/10.1016/j.euros.2024.06.006
[15] 中国抗癌协会男性生殖系统肿瘤专业委员会. 前列腺癌全程管理专家共识(2025版) [J]. 中华肿瘤杂志, 2025, 47(7): 617-634.
[16] Tappero, S., Piccinelli, M.L., Incesu, R., Cano Garcia, C., Barletta, F., Morra, S., et al. (2024) Overall Survival of Metastatic Prostate Cancer Patients According to Location of Visceral Metastatic Sites. Clinical Genitourinary Cancer, 22, 47-55.e2.
https://doi.org/10.1016/j.clgc.2023.08.004