脓毒症生物标志物研究进展：多组学机制解析与临床转化挑战
Research Advances in Sepsis Biomarkers: Multi-Omics Mechanistic Insights and Challenges in Clinical Translation
DOI: 10.12677/acm.2026.1682864, PDF,    科研立项经费支持
作者: 陈静珊：赣南医科大学第一临床医学院，江西 赣州；陈章宇, 罗开源*：赣南医科大学第一附属医院PICU，江西 赣州
关键词: 生物标志物；脓毒症；临床转化；Biomarkers； Sepsis； Clinical Translation
摘要: 脓毒症是由宿主对感染反应失调引起的危及生命的器官功能障碍，是一种病情进展迅速、死亡率高的临床常见危重疾病。其病理生理涉及免疫失调、代谢紊乱、微循环障碍及器官功能障碍等多个方面，尽管脓毒症治疗的临床指南有所发展，但脓毒症患者的识别、个体化治疗及预后判断在临床上仍然是一个重大挑战。临床一直致力于确定基于病理生理的生物标志物来帮助诊治脓毒症，本文系统综述了脓毒症生物标志物的研究进展，依托多组学技术驱动下代谢、免疫及表观遗传的机制解析，论证脓毒症精准诊疗必须完成从传统单一生物标志物向类型特异性标志物组合的范式转移，并对脓毒症精准医学的未来发展进行展望。
Abstract: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection, representing a common critical illness characterized by rapid disease progression and high mortality. Its pathophysiology encompasses multiple dimensions including immune dysregulation, metabolic disturbance, microcirculatory dysfunction, and organ dysfunction. Despite advances in clinical guidelines for sepsis management, the identification, individualized treatment, and prognostic stratification of sepsis patients remain major clinical challenges. Clinical research has long been dedicated to identifying pathophysiology-based biomarkers to facilitate the diagnosis and treatment of sepsis. This article systematically reviews research advances in sepsis biomarkers, dissects the mechanistic insights into metabolic, immune, and epigenetic alterations driven by multi-omics technologies, argues that precision diagnosis and treatment of sepsis must undergo a paradigm shift from traditional single biomarkers to type-specific biomarker panels, and offers perspectives on the future development of precision medicine in sepsis.
文章引用：陈静珊, 陈章宇, 罗开源. 脓毒症生物标志物研究进展：多组学机制解析与临床转化挑战[J]. 临床医学进展, 2026, 16(8): 898-907. https://doi.org/10.12677/acm.2026.1682864

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