基于miRNA探究针刺治疗卒中后抑郁的机制研究进展
Research Progress on the Mechanism of Acupuncture in Treating Post-Stroke Depression Based on miRNA
DOI: 10.12677/jcpm.2026.54249, PDF,   
作者: 王 昭, 李晶怡, 刘 月：黑龙江中医药大学研究生院，黑龙江 哈尔滨；王东岩*：黑龙江中医药大学附属第二医院针灸三科，黑龙江 哈尔滨
关键词: 卒中后抑郁；微小核糖核酸；针刺；机制 ；Post-Stroke Depression； microRNA； Acupuncture； Mechanism
摘要: 卒中后抑郁(PSD)是脑卒中常见且严重的并发症，严重影响患者的康复及生活质量。微小核糖核酸(miRNA)作为一类重要的内源性非编码RNA，在PSD的发病机制中发挥着关键作用。针刺疗法作为传统中医疗法，在PSD的治疗中显示出一定优势，且越来越多的研究表明针刺可能间接通过调节miRNA的表达来发挥抗抑郁作用。本文综述了miRNA在PSD发病机制中的作用，以及针刺治疗PSD可能涉及的miRNA相关机制，旨在为PSD的治疗提供新的思路和理论依据。
Abstract: Post-stroke depression (PSD) is a common and serious complication following stroke, significantly affecting patients’ recovery and quality of life. MicroRNAs (miRNAs), a class of important endogenous non-coding RNAs, play a crucial role in the pathogenesis of PSD. Acupuncture, a traditional Chinese medicine therapy, has shown certain advantages in treating PSD, and increasing evidence suggests that acupuncture may exert its antidepressant effects by modulating miRNA expression. This review summarizes the role of miRNAs in the pathogenesis of PSD and discusses potential miRNA-related mechanisms underlying acupuncture treatment for PSD, aiming to provide new insights and theoretical foundations for PSD management.
文章引用：王昭, 王东岩, 李晶怡, 刘月. 基于miRNA探究针刺治疗卒中后抑郁的机制研究进展[J]. 临床个性化医学, 2026, 5(4): 273-279. https://doi.org/10.12677/jcpm.2026.54249

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