男性精子相关因素与复发性流产相关性研究的国内外现状综述
Research Status Review at Home and Abroad on the Correlation between Male Sperm-Related Factors and Recurrent Spontaneous Abortion
摘要: 复发性流产(Recurrent Spontaneous Abortion, RSA)是生殖医学常见疾病，病因复杂，涉及男女双方多种因素。近年来，男性因素在RSA中的作用日益受到关注，其中精子质量相关指标成为研究热点。本文系统综述国内外相关研究，从精子DNA碎片率(DFI)、精液常规参数、精浆生化指标、精子核蛋白组型及染色体异常等方面，梳理男性精子因素与RSA的相关性研究现状，总结共识与争议，并展望未来方向，以期为RSA的病因诊断与临床干预提供参考。
Abstract: Recurrent Spontaneous Abortion (RSA) is a common disease in reproductive medicine with complex etiologies involving multiple factors from both male and female partners. In recent years, increasing attention has been paid to the role of male factors in RSA, among which indicators related to sperm quality have become a research hotspot. This paper systematically reviews relevant domestic and overseas studies, sorts out the research progress on the correlation between male sperm-related factors and RSA from the perspectives of sperm DNA fragmentation index (DFI), routine semen parameters, seminal plasma biochemical indicators, sperm nucleoprotein patterns and chromosomal abnormalities, summarizes existing consensuses and controversies, and prospects future research directions, so as to provide references for etiological diagnosis and clinical intervention of RSA.
文章引用：周星宇, 艾佳文, 张泽璐, 薛娟. 男性精子相关因素与复发性流产相关性研究的国内外现状综述[J]. 临床医学进展, 2026, 16(8): 970-977. https://doi.org/10.12677/acm.2026.1682871

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