人工智能心电图在心血管疾病早期筛查与风险预测中的研究进展
Research Progress of Artificial Intelligence-Enabled Electrocardiography in Early Screening and Risk Prediction of Cardiovascular Diseases
DOI: 10.12677/acm.2026.1682886, PDF,    科研立项经费支持
作者: 陈佳兴, 梅宵宵, 沈楚豪, 蒋铭涛, 谢芝琬:南通大学杏林学院,江苏 南通;朱蕙霞:南通大学医学院,江苏 南通
关键词: 心血管疾病;人工智能;心电图;早期筛查;风险预测;深度学习;Cardiovascular Disease; Artificial Intelligence; Electrocardiogram; Early Screening; Risk Prediction; Deep Learning
摘要: 心电图(Electrocardiogram, ECG)是临床最常用的无创心电检查工具,传统上主要用于诊断既有心律失常与心肌缺血。近年来,随着人工智能(Artificial Intelligence, AI)技术的快速发展,人工智能心电图不仅提升了疾病诊断的准确性,更在心血管疾病的早期筛查与风险预测方面展现出巨大潜力。本文旨在系统综述人工智能辅助心电图诊断(Artificial Intelligence-enabled Electrocardiogram, AI-ECG)在心律失常、心力衰竭、心肌病、结构性心脏病等心血管疾病的早期识别与风险分层中的最新研究进展,并探讨其临床转化面临的挑战与未来方向。
Abstract: The electrocardiogram (ECG) is the most widely utilized non-invasive tool in clinical practice, traditionally employed for diagnosing established arrhythmias and myocardial ischemia. In recent years, with the rapid advancement of artificial intelligence (AI) technology, AI-enabled electrocardiography (AI-ECG) has not only improved diagnostic accuracy but also demonstrated significant potential in the early screening and risk prediction of cardiovascular diseases. This article aims to systematically review the latest research progress of AI-ECG in the early identification and risk stratification of cardiovascular conditions—including arrhythmias, heart failure, cardiomyopathy, and structural heart disease—while discussing the challenges of clinical translation and future directions in this field.
文章引用:陈佳兴, 梅宵宵, 沈楚豪, 蒋铭涛, 谢芝琬, 朱蕙霞. 人工智能心电图在心血管疾病早期筛查与风险预测中的研究进展[J]. 临床医学进展, 2026, 16(8): 1108-1116. https://doi.org/10.12677/acm.2026.1682886

参考文献

[1] 王觅也, 郑涛, 刘然. 基于人工智能的心梗风险预测辅助决策系统研发[J]. 中国卫生信息管理杂志, 2021, 18(6): 819-824+842.
[2] 周和, 徐亚伟. 评价智能心电检测仪诊断心律失常的准确性[J]. 北京生物医学工程, 2022, 41(1): 73-78.
[3] 李方江, 张爱爱, 张鹏祥, 等. 人工智能心电监测在心律失常检测中的应用价值[J]. 河北医药, 2022, 44(2): 192-195.
[4] 罗秋实, 朱红玲, 杨晓云. 人工智能心电图的现状和未来[J]. 临床心电学杂志, 2024, 33(2): 120-125.
[5] Attia, Z.I., Harmon, D.M., Behr, E.R. and Friedman, P.A. (2021) Application of Artificial Intelligence to the Electrocardiogram. European Heart Journal, 42, 4717-4730.
https://doi.org/10.1093/eurheartj/ehab649
[6] Yasmin, F., Shah, S.M.I., Naeem, A., Shujauddin, S.M., Jabeen, A., Kazmi, S., et al. (2021) Artificial Intelligence in the Diagnosis and Detection of Heart Failure: The Past, Present, and Future. Reviews in Cardiovascular Medicine, 22, 1095-1113.
https://doi.org/10.31083/j.rcm2204121
[7] Nagarajan, V.D., Lee, S., Robertus, J., Nienaber, C.A., Trayanova, N.A. and Ernst, S. (2021) Artificial Intelligence in the Diagnosis and Management of Arrhythmias. European Heart Journal, 42, 3904-3916.
https://doi.org/10.1093/eurheartj/ehab544
[8] Siontis, K.C., Noseworthy, P.A., Attia, Z.I. and Friedman, P.A. (2021) Artificial Intelligence-Enhanced Electrocardiography in Cardiovascular Disease Management. Nature Reviews Cardiology, 18, 465-478.
https://doi.org/10.1038/s41569-020-00503-2
[9] Hassannataj Joloudari, J., Mojrian, S., Nodehi, I., Mashmool, A., Kiani Zadegan, Z., Khanjani Shirkharkolaie, S., et al. (2022) Application of Artificial Intelligence Techniques for Automated Detection of Myocardial Infarction: A Review. Physiological Measurement, 43, 08TR01.
https://doi.org/10.1088/1361-6579/ac7fd9
[10] 黎明, 张宇霞, 蔡卫卫, 等. 人工智能心电算法对临床心律失常检测的有效性评估[J]. 实用心电学杂志, 2020, 29(3): 153-156.
[11] 杨柳青青, 蔡於馨, 方婕, 等. 人工智能心电分析技术在心律失常诊断中的应用研究进展[J]. 实用心电学杂志, 2024, 33(5): 499-504.
[12] Jabbour, G., Nolin-Lapalme, A., Tastet, O., Corbin, D., Jordà, P., Sowa, A., et al. (2024) Prediction of Incident Atrial Fibrillation Using Deep Learning, Clinical Models, and Polygenic Scores. European Heart Journal, 45, 4920-4934.
https://doi.org/10.1093/eurheartj/ehae595
[13] Khurshid, S., Friedman, S.F., Kany, S., Mahajan, R., Turner, A.C., Lubitz, S.A., et al. (2024) Electrocardiogram-Based Artificial Intelligence to Discriminate Cardioembolic Stroke and Stratify Risk of Atrial Fibrillation after Stroke. Circulation: Arrhythmia and Electrophysiology, 17, e012959.
https://doi.org/10.1161/circep.124.012959
[14] Jin, Y., Ko, B., Chang, W., Choi, K. and Lee, K.H. (2025) Explainable Paroxysmal Atrial Fibrillation Diagnosis Using an Artificial Intelligence-Enabled Electrocardiogram. The Korean Journal of Internal Medicine, 40, 251-261.
https://doi.org/10.3904/kjim.2024.130
[15] Lou, Y., Lin, C., Fang, W., Lee, C., Ho, C., Wang, C., et al. (2022) Artificial Intelligence-Enabled Electrocardiogram Estimates Left Atrium Enlargement as a Predictor of Future Cardiovascular Disease. Journal of Personalized Medicine, 12, Article 315.
https://doi.org/10.3390/jpm12020315
[16] Jacobs, J.E.J., Greason, G., Mangold, K.E., et al. (2024) Artificial Intelligence Electrocardiogram as a Novel Screening Tool to Detect a Newly Abnormal Left Ventricular Ejection Fraction after Anthracycline-Based Cancer Therapy. European Journal of Preventive Cardiology, 31, 560-566.
[17] Chou, C., Liu, Z., Chang, P., Liu, H., Wo, H., Lee, W., et al. (2024) Comparing Artificial Intelligence-Enabled Electrocardiogram Models in Identifying Left Atrium Enlargement and Long-Term Cardiovascular Risk. Canadian Journal of Cardiology, 40, 585-594.
https://doi.org/10.1016/j.cjca.2023.12.025
[18] Adedinsewo, D.A., Morales-Lara, A.C., Afolabi, B.B., Kushimo, O.A., Mbakwem, A.C., Ibiyemi, K.F., et al. (2025) Author Correction: Artificial Intelligence Guided Screening for Cardiomyopathies in an Obstetric Population: A Pragmatic Randomized Clinical Trial. Nature Medicine, 31, 1715-1715.
https://doi.org/10.1038/s41591-025-03554-5
[19] de Vries, I.R., van Laar, J.O.E.H., van der Hout-van der Jagt, M.B., Clur, S.B. and Vullings, R. (2023) Fetal Electrocardiography and Artificial Intelligence for Prenatal Detection of Congenital Heart Disease. Acta Obstetricia et Gynecologica Scandinavica, 102, 1511-1520.
https://doi.org/10.1111/aogs.14623
[20] Nogimori, Y., Sato, K., Takamizawa, K., Ogawa, Y., Tanaka, Y., Shiraga, K., et al. (2024) Prediction of Adverse Cardiovascular Events in Children Using Artificial Intelligence-Based Electrocardiogram. International Journal of Cardiology, 406, Article 132019.
https://doi.org/10.1016/j.ijcard.2024.132019
[21] Valente Silva, B., Marques, J., Nobre Menezes, M., Oliveira, A.L. and Pinto, F.J. (2023) Artificial Intelligence-Based Diagnosis of Acute Pulmonary Embolism: Development of a Machine Learning Model Using 12-Lead Electrocardiogram. Revista Portuguesa de Cardiologia, 42, 643-651.
https://doi.org/10.1016/j.repc.2023.03.016
[22] Lee, M.S., Shin, T.G., Lee, Y., Kim, D.H., Choi, S.H., Cho, H., et al. (2025) Artificial Intelligence Applied to Electrocardiogram to Rule Out Acute Myocardial Infarction: The ROMIAE Multicentre Study. European Heart Journal, 46, 1917-1929.
https://doi.org/10.1093/eurheartj/ehaf004
[23] Fiorina, L., Carbonati, T., Narayanan, K., Li, J., Henry, C., Singh, J.P., et al. (2025) Near-Term Prediction of Sustained Ventricular Arrhythmias Applying Artificial Intelligence to Single-Lead Ambulatory Electrocardiogram. European Heart Journal, 46, 1998-2008.
https://doi.org/10.1093/eurheartj/ehaf073
[24] Fu, Z., Hong, S., Zhang, R. and Du, S. (2021) Artificial-Intelligence-Enhanced Mobile System for Cardiovascular Health Management. Sensors, 21, Article 773.
https://doi.org/10.3390/s21030773
[25] Sau, A., Pastika, L., Sieliwonczyk, E., et al. (2024) Artificial Intelligence-Enabled Electrocardiogram for Mortality and Cardiovascular Risk Estimation: A Model Development and Validation Study. The Lancet Digital Health, 6, e791-e802.
[26] Liang, Y., Sau, A., Zeidaabadi, B., Barker, J., Patlatzoglou, K., Pastika, L., et al. (2025) Artificial Intelligence-Enhanced Electrocardiography to Predict Regurgitant Valvular Heart Diseases: An International Study. European Heart Journal, 46, 4823-4837.
https://doi.org/10.1093/eurheartj/ehaf448
[27] Maille, B., Wilkin, M., Million, M., Rességuier, N., Franceschi, F., Koutbi-Franceschi, L., et al. (2021) Smartwatch Electrocardiogram and Artificial Intelligence for Assessing Cardiac-Rhythm Safety of Drug Therapy in the COVID-19 Pandemic. The Qt-Logs Study. International Journal of Cardiology, 331, 333-339.
https://doi.org/10.1016/j.ijcard.2021.01.002
[28] Yagi, R., Goto, S., Himeno, Y., Katsumata, Y., Hashimoto, M., MacRae, C.A., et al. (2024) Artificial Intelligence-Enabled Prediction of Chemotherapy-Induced Cardiotoxicity from Baseline Electrocardiograms. Nature Communications, 15, Article No. 2536.
https://doi.org/10.1038/s41467-024-45733-x
[29] Amadio, J.M., Grogan, M., Muchtar, E., Lopez-Jimenez, F., Attia, Z.I., AbouEzzeddine, O., et al. (2024) Predictors of Mortality by an Artificial Intelligence Enhanced Electrocardiogram Model for Cardiac Amyloidosis. ESC Heart Failure, 12, 677-682.
https://doi.org/10.1002/ehf2.15061
[30] Sau, A., Sieliwonczyk, E., Patlatzoglou, K., Pastika, L., McGurk, K.A., Ribeiro, A.H., et al. (2025) Artificial Intelligence-Enhanced Electrocardiography for the Identification of a Sex-Related Cardiovascular Risk Continuum: A Retrospective Cohort Study. The Lancet Digital Health, 7, e184-e194.
https://doi.org/10.1016/j.landig.2024.12.003
[31] Johnson, L.S., Zadrozniak, P., Jasina, G., Grotek-Cuprjak, A., Andrade, J.G., Svennberg, E., et al. (2025) Artificial Intelligence for Direct-to-Physician Reporting of Ambulatory Electrocardiography. Nature Medicine, 31, 925-931.
https://doi.org/10.1038/s41591-025-03516-x
[32] Mayourian, J., El-Bokl, A., Lukyanenko, P., La Cava, W.G., Geva, T., Valente, A.M., et al. (2024) Electrocardiogram-Based Deep Learning to Predict Mortality in Paediatric and Adult Congenital Heart Disease. European Heart Journal, 46, 856-868.
https://doi.org/10.1093/eurheartj/ehae651