注意缺陷多动障碍与肠道微生物异常表现研究进展

Research Progress on Attention Deficit Hyperactivity Disorder and Intestinal Microbiological Abnormalities

摘要: 注意缺陷多动障碍是一种起病于儿童期的神经发育障碍，以注意力不集中、多动–冲动为核心特征。近年来众多学者围绕“微生物–肠–脑轴”开展研究，探究肠道微生态与中枢神经系统之间双向联结，注意缺陷多动障碍儿童也常表现出胃肠道功能异常，研究表明其核心症状可能与肠道微生态之间存在密切联系。本文分析了肠道菌群影响注意缺陷多动障碍的可能机制，并综述注意缺陷多动障碍儿童肠道微生态异常特征和临床证据，本文能够为理解注意缺陷多动障碍的病理机制和开展临床管理提供新的视角。

Abstract: Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder that starts in childhood and is characterized by inattention and hyperactivity impulsivity. In recent years, many scholars have carried out research around the “microbial gut brain axis” to explore the two-way connection between the intestinal microecology and the central nervous system. Children with attention deficit hyperactivity disorder also often show gastrointestinal dysfunction. Research shows that the core symptoms may be closely related to the intestinal microecology. This paper analyzes the possible mechanism of intestinal flora affecting attention deficit hyperactivity disorder, and reviews the characteristics and clinical evidence of intestinal microecology abnormalities in children with attention deficit hyperactivity disorder. This paper can provide a new perspective for understanding the mechanism of attention deficit hyperactivity disorder and developing clinical management.