水平离心富血小板纤维蛋白在组织再生中的研究进展
Research Progress of Horizontal-PRF in Tissue Regeneration
DOI: 10.12677/acm.2026.1682915, PDF,    科研立项经费支持
作者: 徐 苍:国药一机医院(内蒙古医科大学第四附属医院)口腔颌面外科,内蒙古 包头;吕守印*:内蒙古自治区人民医院数字口腔种植中心,内蒙古 呼和浩特
关键词: 水平离心富血小板纤维蛋白;组织再生;血管新生;免疫调控;自体生物材料;Horizontal Centrifuged Platelet-Rich Fibrin (H-PRF); Tissue Regeneration; Angiogenesis; Immune Regulation; Autologous Biomaterials
摘要: 水平离心富血小板纤维蛋白(H-PRF)是改良传统PRF离心工艺的新型自体生物材料,有效解决了传统PRF细胞分布不均、生物活性不稳定等缺陷。其特殊水平离心模式可实现血小板、免疫细胞均匀富集,构建均质三维纤维蛋白网络,结合适度热处理可优化理化性能、延缓降解,实现再生因子长效缓释。H-PRF可通过激活相关信号通路促进血管新生,同时动态调控免疫微环境,兼具抗菌、抗炎、促组织修复多重功效,在软硬组织再生领域优势显著。目前H-PRF存在热处理参数不统一、材料成分异质性等技术瓶颈,缺乏标准化制备与评价体系。本文综述H-PRF的技术演进、结构功能机制及现存问题,旨在为其基础研究深化与临床规范化转化提供理论参考。
Abstract: Horizontal centrifuged platelet-rich fibrin (H-PRF) is a novel autologous biomaterial modified based on the conventional PRF centrifugation technique, which effectively overcomes the limitations of traditional PRF, including uneven cell distribution and unstable biological activity. Its unique horizontal centrifugation mode enables the uniform enrichment of platelets and immune cells and constructs a homogeneous three-dimensional fibrin network. Combined with appropriate heat treatment, H-PRF exhibits optimized physicochemical properties, delayed degradation, and sustained release of regenerative factors. By activating related signaling pathways, H-PRF promotes angiogenesis and dynamically regulates the immune microenvironment, possessing multiple functions of antibacterial, anti-inflammatory, and tissue repair effects with prominent advantages in soft and hard tissue regeneration. At present, the clinical application and basic research of H-PRF are restricted by technical bottlenecks, such as inconsistent heat treatment parameters and material heterogeneity, as well as the lack of standardized preparation and evaluation systems. This paper reviews the technological evolution, structural and functional mechanisms, and existing challenges of H-PRF, aiming to provide a theoretical reference for its in-depth basic research and standardized clinical transformation.
文章引用:徐苍, 吕守印. 水平离心富血小板纤维蛋白在组织再生中的研究进展[J]. 临床医学进展, 2026, 16(8): 1389-1398. https://doi.org/10.12677/acm.2026.1682915

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