p62在肺部疾病中的研究进展
Research Progress of p62 in Lung Diseases
DOI: 10.12677/acm.2026.1682951, PDF,   
作者: 时拥月, 李小波*：成都市第七人民医院呼吸与危重症医学科，四川 成都
关键词: p62/SQSTM1；自噬；肺部疾病；信号通路；靶向治疗；p62/SQSTM1； Autophagy； Lung Diseases； Signal Pathway； Targeted Therapy
摘要: p62/SQSTM1本质上是一种衔接蛋白，具备多种生物学功能。作为选择性自噬受体，它在细胞内蛋白质质量控制中发挥关键作用。最新研究表明，p62不仅参与自噬介导的底物降解，还能整合NF-κB、mTORC1和Keap1-NRF2等信号通路，在细胞应激、炎症调控和代谢重塑中扮演信号中枢的角色。在肺部疾病领域，p62的异常表达和功能失调与肺癌、慢阻肺、肺动脉高压、急性肺损伤/急性呼吸窘迫综合征以及特发性肺纤维化等多种肺部疾病的发病机制密切相关。本文系统综述p62的分子结构、功能调控及其在各类肺部疾病中的研究进展，并对基于p62的治疗策略前景进行展望。
Abstract: p62/SQSTM1 is essentially an adaptor protein with diverse functions. Among them, as a selective autophagy receptor, it plays a core role in the control of intracellular protein quality. Recent studies have shown that p62 not only participates in autophagy-mediated substrate degradation, but also plays the role of a signaling center in cellular stress, inflammatory regulation and metabolic remodeling by integrating multiple signaling pathways such as NF-κB, mTORC1 and Keap1-NRF2. In the field of pulmonary diseases, the abnormal expression and dysfunction of p62 are closely related to the pathogenesis of various pulmonary diseases such as lung cancer, chronic obstructive pulmonary disease, pulmonary hypertension, acute lung injury/acute respiratory distress syndrome, and idiopathic pulmonary fibrosis. This article systematically reviews the molecular structure and functional regulation of p62 and its research progress in various lung diseases, and looks forward to the prospects of treatment strategies based on p62.
文章引用：时拥月, 李小波. p62在肺部疾病中的研究进展[J]. 临床医学进展, 2026, 16(8): 1693-1699. https://doi.org/10.12677/acm.2026.1682951

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