基于线粒体动力学探讨中医药干预心肌肥大的研究进展
Research Progress on Traditional Chinese Medicine Intervention in Cardiac Hypertrophy Based on Mitochondrial Dynamics
DOI: 10.12677/acm.2026.1682959, PDF,   
作者: 沈师奇：黑龙江中医药大学研究生院，黑龙江 哈尔滨；赵文霞, 袁晖戍*：黑龙江中医药大学附属第二医院哈南分院心病一科，黑龙江 哈尔滨
关键词: 线粒体动力学；心肌肥大；中医药；Mitochondrial Dynamics； Cardiac Hypertrophy； Traditional Chinese Medicine
摘要: 心肌肥大是心脏在病理刺激下发生的代偿性结构重塑，是心力衰竭等心血管疾病的重要前期病变。线粒体动力学是调控线粒体融合、分裂动态平衡以维持其结构与功能稳定的过程，对能量代谢与维持细胞稳态至关重要。在心肌肥大进程中存在线粒体动力学失衡，表现为线粒体过度分裂和(或)融合功能受损。中医药凭借多靶点、多通路整体调节优势，在调控线粒体动力学平衡、改善心肌肥大方面展现出良好前景。本文系统梳理线粒体动力学的分子机制及其在心肌肥大中的作用、归纳中医药干预研究进展，为中医药靶向线粒体动力学防治心肌肥大提供理论依据与研究思路。
Abstract: Cardiac hypertrophy is a compensatory structural remodeling of the heart under pathological stimuli, which serves as an important preclinical lesion of cardiovascular diseases such as heart failure. Mitochondrial dynamics refers to the process that regulates the dynamic equilibrium of mitochondrial fusion and fission to maintain structural and functional stability, and is crucial for energy metabolism and cellular homeostasis. Imbalanced mitochondrial dynamics exists during the progression of cardiac hypertrophy, characterized by excessive mitochondrial fission and/or impaired fusion. With the advantages of multi-target and multi-pathway holistic regulation, traditional Chinese medicine (TCM) has shown promising prospects in regulating mitochondrial dynamic balance and alleviating cardiac hypertrophy. This paper systematically reviews the molecular mechanism of mitochondrial dynamics and its role in cardiac hypertrophy, summarizes the research progress of TCM intervention, and provides theoretical basis and research ideas for the prevention and treatment of cardiac hypertrophy by targeting mitochondrial dynamics with TCM.
文章引用：沈师奇, 赵文霞, 袁晖戍. 基于线粒体动力学探讨中医药干预心肌肥大的研究进展[J]. 临床医学进展, 2026, 16(8): 1760-1768. https://doi.org/10.12677/acm.2026.1682959

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