TBK1在炎症性疾病中的调控机制与研究进展
Regulatory Mechanisms and Research Progress of TBK1 in Inflammatory Diseases
摘要: TANK结合激酶1 (TANK-binding kinase 1, TBK1)是先天免疫调控网络的核心丝氨酸/苏氨酸蛋9白激酶，通过介导核因子κB (nuclear factor kappa-B, NF-κB)、I型干扰素等炎症信号通路活化，调控线粒体稳态及细胞程序性死亡，在类风湿关节炎、骨关节炎、银屑病等多种炎症性疾病中发挥关键作用。TBK1的生物学功能具有疾病微环境依赖性和靶点特异性，可通过磷酸化不同底物特定位点实现促炎或抗炎的双向调控，其功能异常是免疫稳态失衡、炎症持续放大的重要机制。本文结合最新研究成果，从TBK1的基础生物学特征、炎症调控核心通路、在常见炎症性疾病中的特异性作用及靶向治疗研究进展等方面进行综述，为炎症性疾病的机制研究和靶向药物研发提供理论参考。
Abstract: TANK-binding kinase 1 (TBK1) is a core serine/threonine protein kinase in the innate immune regulatory network. By mediating the activation of inflammatory signaling pathways such as nuclear factor kappa-B (NF-κB) and type I interferons, it regulates mitochondrial homeostasis and programmed cell death, playing a key role in various inflammatory diseases including rheumatoid arthritis, osteoarthritis, and psoriasis. The biological functions of TBK1 are dependent on disease microenvironment and target-specific, achieving bidirectional regulation of pro-inflammatory or anti-inflammatory effects by phosphorylating specific sites of different substrates. Its functional abnormality is an important mechanism for immune homeostasis imbalance and sustained inflammation amplification. This article reviews recent research progress on the basic biological characteristics of TBK1, core inflammatory regulatory pathways, specific roles in common inflammatory diseases, and targeted therapy research, providing theoretical reference for mechanism research and targeted drug development of inflammatory diseases.
文章引用：贾舒涵, 李欣怡, 申梓晨, 任晨阳, 张会梓. TBK1在炎症性疾病中的调控机制与研究进展[J]. 临床医学进展, 2026, 16(8): 1953-1959. https://doi.org/10.12677/acm.2026.1682982

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