系统性炎症反应指数预测急性前循环大血管闭塞取栓预后的研究进展
Research Progress on the Systemic Inflammation Response Index in Predicting Prognosis after Thrombectomy for Acute Anterior Circulation Large Vessel Occlusion
DOI: 10.12677/jcpm.2026.54277, PDF,   
作者: 郭城余*, 吕 哲, 周 杰：延安大学延安医学院，陕西 延安；延安大学附属医院神经外科，陕西 延安；郭 杰#：延安大学附属医院神经外科，陕西 延安
关键词: 系统性炎症反应指数；急性前循环大血管闭塞；机械取栓；无效再通 ；Systemic Inflammation Response Index； Acute Anterior Circulation Large Vessel Occlusion； Mechanical Thrombectomy； Futile Recanalization
摘要: 急性前循环大血管闭塞(ACALVO)是神经血管外科的急重症，具有极高的致死致残率。尽管机械取栓(MT)已成为其标准治疗方案，但仍有约50%的患者面临“无效再通”的困境。因此急需一个简便、经济且易于获取的生物标志物来辅助临床进行早期风险分层和预后判断。系统性炎症反应指数(SIRI)作为一种基于外周血中性粒细胞、单核细胞和淋巴细胞计数所得的新型炎症标志物，对ACALVO患者MT后无效再通、功能预后具有独特的预测价值。本文系统地梳理了SIRI预测ACALVO患者MT预后的相关研究进展，旨在为临床医生提供有价值的参考，以促进其临床决策的科学化。未来还需多中心、大样本的前瞻性研究来验证其临床效用，以推动其在临床的广泛应用。
Abstract: Acute Anterior Circulation Large Vessel Occlusion (ACALVO) is a critical emergency in neurovascular surgery. It has extremely high rates of death and disability. Mechanical thrombectomy (MT) has become the standard treatment. Yet about 50% of patients still face the problem of “futile recanalization”. Therefore, a simple, inexpensive, and easily accessible biomarker is urgently needed. It can assist in early risk stratification and prognosis assessment. The systemic inflammation response index (SIRI) is a novel inflammatory biomarker. It is calculated from peripheral blood neutrophil, monocyte, and lymphocyte counts. SIRI has unique predictive value for futile recanalization after MT in ACALVO patients. It also has predictive value for functional outcome. This article systematically reviews the relevant research progress. The aim is to provide a valuable reference for clinicians. This can help make clinical decision-making more scientific. Future multicenter, large-sample prospective studies are needed to validate its clinical utility. This will promote its widespread clinical application.
文章引用：郭城余, 郭杰, 吕哲, 周杰. 系统性炎症反应指数预测急性前循环大血管闭塞取栓预后的研究进展[J]. 临床个性化医学, 2026, 5(4): 511-518. https://doi.org/10.12677/jcpm.2026.54277

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