盆腔脏器脱垂术前隐匿性尿失禁评估及手术治疗策略的研究进展
Research Progress on Preoperative Assessment of Concealed Urinary Incontinence and Surgical Treatment Strategies for Pelvic Organ Prolapse
摘要: 盆腔脏器脱垂(Pelvic Organ Prolapse, POP)与压力性尿失禁(Stress Urinary Incontinence, SUI)是两种高度共存的盆底功能障碍性疾病。隐匿性尿失禁(Occult Stress Urinary Incontinence, OSUI)作为其间的一种特殊类型,指患者在脱垂状态下无漏尿症状,但在脱垂复位后出现SUI表现。OSUI的存在使POP手术决策变得复杂:若未识别OSUI,术后可能发生新发SUI (de novo SUI);若对所有患者常规行预防性抗尿失禁手术,又可能导致过度治疗。本文从评估技术视角、风险预测视角和临床决策视角出发,系统综述OSUI的病理机制、诊断方法、预测模型及治疗策略的研究进展。研究表明,术前OSUI的阳性预测值约为40%,但其阴性预测值可高达91%,这一特征决定了OSUI评估的核心价值在于“排除风险”而非“确定诊断”。当前评估手段仍以咳嗽压力试验和尿动力学检查为主,盆底超声作为无创补充手段展现出潜力,但缺乏统一的诊断标准和截断值。在治疗策略上,同期行抗尿失禁手术可显著降低术后SUI发生率,但需权衡过度治疗的风险。未来研究应致力于建立标准化的OSUI诊断流程、开发更精准的预测模型,并通过高质量随机对照试验明确不同人群的最佳治疗策略。
Abstract: Pelvic organ prolapse (POP) and stress urinary incontinence (SUI) are two highly coexisting pelvic floor functional disorders. Occult stress urinary incontinence (OSUI), as a special type among them, refers to the situation where patients have no leakage symptoms during prolapse but exhibit SUI manifestations after prolapse is restored. The existence of OSUI complicates the decision-making for POP surgeries: if OSUI is not identified, new-onset SUI (de novo SUI) may occur after surgery; if preventive anti-incontinence surgeries are routinely performed for all patients, it may lead to over-treatment. This article reviews the research progress in the pathogenesis, diagnostic methods, prediction models, and treatment strategies of OSUI from the perspectives of assessment techniques, risk prediction, and clinical decision-making. The study shows that the positive predictive value of OSUI before surgery is approximately 40%, but its negative predictive value can reach up to 91%. This characteristic determines that the core value of OSUI assessment lies in “risk exclusion” rather than “diagnosis confirmation”. Current assessment methods mainly rely on cough pressure tests and urodynamic examinations, and pelvic floor ultrasound as a non-invasive supplementary method shows potential. However, there is a lack of unified diagnostic criteria and cut-off values. In terms of treatment strategies, concurrent anti-incontinence surgeries can significantly reduce the incidence of SUI after surgery, but the risk of over-treatment needs to be weighed. Future research should focus on establishing standardized OSUI diagnostic procedures, developing more accurate prediction models, and conducting high-quality randomized controlled trials to clarify the best treatment strategies for different populations.
文章引用:蒋芙蓉, 周卫华, 田欣, 向虹橙, 金波. 盆腔脏器脱垂术前隐匿性尿失禁评估及手术治疗策略的研究进展[J]. 临床医学进展, 2026, 16(8): 2001-2008. https://doi.org/10.12677/acm.2026.1682988

参考文献

[1] Baessler, K., Christmann-Schmid, C., Haya, N., Mowat, A., Chen, Z., Wallace, S.A., et al. (2026) Surgery for Women with Pelvic Organ Prolapse with or without Stress Urinary Incontinence. Cochrane Database of Systematic Reviews, 2026, CD013108.
https://doi.org/10.1002/14651858.cd013108.pub2
[2] Sato, H., Abe, H., Ikeda, A., Miyagawa, T. and Tsukada, S. (2022) Severity of Cystocele and Risk Factors of Postoperative Stress Urinary Incontinence after Laparoscopic Sacrocolpopexy for Pelvic Organ Prolapse. Gynecology and Minimally Invasive Therapy, 11, 28-35.
https://doi.org/10.4103/gmit.gmit_2_21
[3] Haylen, B.T., de Ridder, D., Freeman, R.M., et al. (2010) An International Urogynecological Association (IUGA)/International Continence Society (ICS) Joint Report on the Terminology for Female Pelvic Floor Dysfunction. Neurourology and Urodynamics, 29, 4-20.
[4] 吴琮璋, 刘婷婷, 倪茗, 等. 盆底重建术联合抗尿失禁手术对盆腔器官脱垂合并隐匿性尿失禁患者的临床效果研究[J]. 现代诊断与治疗, 2023, 34(5): 725-728.
[5] 李星辰. 盆底重建术后新发压力性尿失禁的影响因素研究及风险预测[D]: [硕士学位论文]. 济南: 山东大学, 2023.
[6] van der Ploeg, J., van der Steen, A., Zwolsman, S., van der Vaart, C. and Roovers, J. (2018) Prolapse Surgery with or without Incontinence Procedure: A Systematic Review and Meta-Analysis. BJOG: An International Journal of Obstetrics & Gynaecology, 125, 289-297.
https://doi.org/10.1111/1471-0528.14943
[7] Richardson, D.A., Bent, A.E. and Ostergard, D.R. (1983) The Effect of Uterovaginal Prolapse on Urethrovesical Pressure Dynamics. American Journal of Obstetrics and Gynecology, 146, 901-905.
https://doi.org/10.1016/0002-9378(83)90961-4
[8] Rosato, E., Vacca, L., Lombisani, A., Campagna, G., Orecchia, L., Bianchi, D., et al. (2025) Is There a Role for Urodynamic Investigation in the Management of Pelvic Organ Prolapse? Journal of Clinical Medicine, 14, Article 1163.
https://doi.org/10.3390/jcm14041163
[9] Wang, H., Shen, J., Li, S., Gao, Z., Ke, K. and Gu, P. (2022) The Feasibility of Uterine-Vaginal Axis MRI-Based as Evaluation of Surgical Efficacy in Women with Pelvic Organ Prolapse. Annals of Translational Medicine, 10, 447.
[10] Yang, X., Wang, X., Gao, Z., Li, L., Lin, H., Wang, H., et al. (2022) The Anatomical Pathogenesis of Stress Urinary Incontinence in Women. Medicina, 59, Article 5.
https://doi.org/10.3390/medicina59010005
[11] Wang, X., Li, L., Gao, Z., Tian, D., Li, Y., Gu, J., et al. (2026) Is Occult Stress Urinary Incontinence Truly “Occult”? Gynecology and Pelvic Medicine, 9, Article 14.
https://doi.org/10.21037/gpm-25-49
[12] 王东升, 郭佳恒, 段永飞, 等. 盆腔器官脱垂术后新发压力性尿失禁研究现状[J]. 疑难病杂志, 2022, 21(11): 1211-1215.
[13] Barbier, H., Carberry, C.L., Karjalainen, P.K., Mahoney, C.K., Galán, V.M., Rosamilia, A., et al. (2023) International Urogynecology Consultation Chapter 2 Committee 3: The Clinical Evaluation of Pelvic Organ Prolapse Including Investigations into Associated Morbidity/Pelvic Floor Dysfunction. International Urogynecology Journal, 34, 2657-2688.
https://doi.org/10.1007/s00192-023-05629-8
[14] Espuña-Pons, M., Diez-Itza, I., Anglès-Acedo, S. and Covernton, P.J.O. (2020) Cough Stress Tests to Diagnose Stress Urinary Incontinence in Women with Pelvic Organ Prolapse with Indication for Surgical Treatment. Neurourology and Urodynamics, 39, 819-825.
https://doi.org/10.1002/nau.24288
[15] Hwang, S.M., de Toledo, L.G.M., da Silva Carramão, S., Frade, A.B., Matos, A.C. and Auge, A.P.F. (2019) Is Urodynamics Necessary to Identify Occult Stress Urinary Incontinence? World Journal of Urology, 37, 189-193.
https://doi.org/10.1007/s00345-018-2366-8
[16] Hwang, S.M., de Toledo, L.G.M., da Silva Carramão, S., de Jesus, C.R.M., de Carvalho, S.Z. and Auge, A.P.F. (2026) Preoperative Urodynamics and the Risk of Overdiagnosis and Overtreatment of Occult Urinary Incontinence in Continent Women with Advanced Pelvic Organ Prolapse. World Journal of Urology, 44, Article No. 350.
https://doi.org/10.1007/s00345-026-06404-2
[17] Schierlitz, L., Dwyer, P.L., Rosamilia, A., De Souza, A., Murray, C., Thomas, E., et al. (2014) Pelvic Organ Prolapse Surgery with and without Tension-Free Vaginal Tape in Women with Occult or Asymptomatic Urodynamic Stress Incontinence: A Randomised Controlled Trial. International Urogynecology Journal, 25, 33-40.
https://doi.org/10.1007/s00192-013-2150-7
[18] Glass, D., Lin, F.C., Khan, A.A., Van Kuiken, M., Drain, A., Siev, M., et al. (2020) Impact of Preoperative Urodynamics on Women Undergoing Pelvic Organ Prolapse Surgery. International Urogynecology Journal, 31, 1663-1668.
https://doi.org/10.1007/s00192-019-04084-8
[19] Serati, M., Salvatore, S., Siesto, G., Cattoni, E., Braga, A., Sorice, P., et al. (2011) Urinary Symptoms and Urodynamic Findings in Women with Pelvic Organ Prolapse: Is There a Correlation? Results of an Artificial Neural Network Analysis. European Urology, 60, 253-260.
https://doi.org/10.1016/j.eururo.2011.03.010
[20] 张秀敏. 经会阴盆底超声在女性隐匿性压力性尿失禁诊断中的应用价值[C]//天津市互联网医学科普协会. 临床医学研究创新学术交流会论文集(第一册). 2026: 1432-1434.
[21] 孙璐璐, 吴宏匀, 陶芸飞, 等. 经阴道三维超声结合POP-Q评分对盆腔器官脱垂盆底重建术前隐匿性压力性尿失禁的诊断价值[J]. 中国医药导报, 2023, 20(10): 138-141.
[22] 杨佳怡, 王珏. 基于经会阴盆底超声参数及阴道三维超声参数的盆腔器官脱垂合并隐匿性压力性尿失禁预测模型构建及验证[J]. 医学临床研究, 2026, 43(2): 193-197.
[23] 张红彬, 孟欣雨, 申朵朵, 等. 隐匿性尿失禁患者盆底超声检查价值[J]. 中国超声医学杂志, 2024, 40(2): 202-205.
[24] 王莹, 黄涵, 吴桐雨, 等. 经会阴三维超声对盆腔器官脱垂合并隐匿性尿失禁诊断价值的研究[J]. 中国医药指南, 2025, 23(7): 1-5.
[25] Hong, Y., Tao, D., Xiao, L., Zhou, Z., Zhang, C., Su, M., et al. (2026) Application Value of Biplane Ultrasound Combined with Multimodal Ultrasound Elastography and Ultra-Micro Angiography in Stress Urinary Incontinence: A Prospective Clinical Study. Quantitative Imaging in Medicine and Surgery, 16, 411.
https://doi.org/10.21037/qims-2025-1147
[26] 盆底功能障碍评估与干预技术多学科共识专家组, 何洪波, 贾小强. 盆底功能多模态评估体系的专家共识[J]. 中国循证医学杂志, 2024, 24(8): 869-875.
[27] Jelovsek, J.E., Chagin, K., Brubaker, L., Rogers, R.G., Richter, H.E., Arya, L., et al. (2014) A Model for Predicting the Risk of De Novo Stress Urinary Incontinence in Women Undergoing Pelvic Organ Prolapse Surgery. Obstetrics & Gynecology, 123, 279-287.
https://doi.org/10.1097/aog.0000000000000094
[28] Su, M., Wang, S. and Liu, X. (2025) Predicting Postoperative Stress Urinary Incontinence after Prolapse Surgery via Machine Learning and Regression Models: Development and Validation Study. JMIR Medical Informatics, 13, e76021.
https://doi.org/10.2196/76021
[29] 丁吉祥. 盆底修复术后新发压力性尿失禁风险预测模型的构建和验证[D]: [硕士学位论文]. 南京: 南京医科大学, 2020.
[30] Kobashi, K.C., Vasavada, S., Bloschichak, A., Hermanson, L., Kaczmarek, J., Kim, S.K., et al. (2023) Updates to Surgical Treatment of Female Stress Urinary Incontinence (SUI): AUA/SUFU Guideline (2023). Journal of Urology, 209, 1091-1098.
https://doi.org/10.1097/ju.0000000000003435
[31] Borstad, E., Abdelnoor, M., Staff, A.C. and Kulseng-Hanssen, S. (2010) Surgical Strategies for Women with Pelvic Organ Prolapse and Urinary Stress Incontinence. International Urogynecology Journal, 21, 179-186.
https://doi.org/10.1007/s00192-009-1007-6
[32] Wei, J.T., Nygaard, I., Richter, H.E., Nager, C.W., Barber, M.D., Kenton, K., et al. (2012) A Midurethral Sling to Reduce Incontinence after Vaginal Prolapse Repair. New England Journal of Medicine, 366, 2358-2367.
https://doi.org/10.1056/nejmoa1111967