乳腺癌前哨淋巴结活检示踪剂应用现状及进展
Current Status and Progress of Sentinel Lymph Node Biopsy Tracers in Breast Cancer
DOI: 10.12677/acm.2026.1682989, PDF,    科研立项经费支持
作者: 黄 雷, 孙洪光, 王玉华, 贾中明, 张国强*：滨州医学院附属医院乳腺外科，山东 滨州；王艳苹：滨州市人民医院医务处，山东 滨州
关键词: 乳腺癌；前哨淋巴结活检；示踪剂；盐酸米托蒽醌注射液；亚甲蓝；吲哚菁绿；Breast Cancer； Sentinel Lymph Node Biopsy； Tracers； Mitoxantrone Hydrochloride Injection； Methylene Blue； Indocyanine Green
摘要: 前哨淋巴结活检(SLNB)目前已经成为早期乳腺癌进行腋窝分期的“金标准”。目前常用示踪剂辅助SLNB，传统示踪剂包括蓝染料、放射性同位素，虽然取得了良好效果，但放射性同位素存在辐射暴露及操作复杂等问题，蓝染料存在过敏、假阴性率高的问题。近年来，随着吲哚菁绿(ICG)和超顺磁性氧化铁(SPIO)等新型示踪剂的出现，进一步提高了SLNB技术的准确性、操作简便性及安全性。本文系统综述当前乳腺癌SLNB中各类示踪剂的应用现状，分析新型示踪剂未来发展方向。
Abstract: Sentinel lymph node biopsy (SLNB) has now become the “gold standard” for axillary staging in early breast cancer. Currently, commonly used tracers assist SLNB, with traditional tracers including blue dye and radioactive isotopes. Although good results have been achieved, radioactive isotopes pose issues such as radiation exposure and operational complexity, while blue dye has problems with allergies and high false-negative rates. In recent years, the emergence of new tracers such as Indocyanine green (ICG) and superparamagnetic iron oxide (SPIO) has further improved the accuracy, operational simplicity, and safety of SLNB technology. This article systematically reviews the current application status of various tracers in breast cancer SLNB and analyzes the future development direction of new tracers.
文章引用：黄雷, 王艳苹, 孙洪光, 王玉华, 贾中明, 张国强. 乳腺癌前哨淋巴结活检示踪剂应用现状及进展[J]. 临床医学进展, 2026, 16(8): 2009-2016. https://doi.org/10.12677/acm.2026.1682989

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