基于“壮火食气”理论探讨酒精性骨质疏松的发病机制

Exploring the Pathogenesis of Alcohol-Induced Osteoporosis from the Perspective of the “Excessive Fire Consumes Qi” Theory

摘要: 本文基于《黄帝内经》“壮火食气”理论探讨酒精性骨质疏松(Alcohol-Induced Osteoporosis, AOP)的发病机制，将“壮火”分为实火和虚火两大类，其中，实火包含酒精本身的火热之性、肝火、病理产物内郁所化之火；虚火则为肝肾阴虚所化之火，四者协同作用，形成“因火致虚，因虚生火”的恶性循环，最终发为骨痿。本文系统梳理历代医家对“壮火食气”的多元诠释，融合中医经典理论和现代医学研究成果，从宏观、微观角度深入阐释AOP的病机演变规律，为后续研究提供理论参考。

Abstract: Based on the “Excessive Fire Consumes Qi” (Zhuang Huo Shi Qi) theory from The Yellow Emperor’s Classic of Internal Medicine, this paper investigates the pathogenesis of alcohol-induced osteoporosis (AOP). The concept of “Excessive Fire” is categorized into two major types: Real Fire and Empty Fire. Real Fire encompasses the inherent fiery nature of alcohol, Liver Fire, and fire transformed from the internal stagnation of pathological products. Empty Fire refers to fire arising from Liver-Kidney Yin deficiency. The synergistic action of these four types of fire establishes a vicious cycle of “fire causing deficiency, and deficiency generating fire”, ultimately culminating in bone atrophy (Wei syndrome). This paper systematically reviews the diverse interpretations of the “Excessive Fire Consumes Qi” theory by renowned physicians throughout history, integrating classical Chinese medicine theories with findings from modern medical research. By elaborating on the pathogenetic evolution of AOP from both macroscopic and microscopic perspectives, this paper aims to provide theoretical references for future investigations.