放疗诱导肿瘤细胞周期再分布的双阶段混合模型

Two-Stage Hybrid Model of Radiation-Induced Tumor Cell Cycle Redistribution

摘要: 放疗是肿瘤治疗的主要手段之一。不同细胞周期阶段的肿瘤细胞对射线的敏感性存在显著差异，且射线照射后的肿瘤细胞会出现细胞周期阻滞现象，引起肿瘤细胞周期的动态再分布。掌握细胞周期再分布的规律，有助于优化放疗的时间间隔，提高放疗的疗效。本文针对放射诱导肿瘤细胞周期的再分布过程，构建了一种由蒙特卡罗模型和仓室模型所组成的双阶段混合模型，前者用于描述每个肿瘤细胞在射线照射后的细胞周期阻滞现象以及细胞周期演进过程，后者用于刻画不同细胞周期阶段的细胞周期种群的动态变化过程。数值结果表明，与单纯使用仓室模型相比较，本文的模型可以更好地模拟射线诱导的细胞周期再分布过程。

Abstract: Radiotherapy is one of the primary modalities for tumor treatment. Tumor cells in different cell cycle phases exhibit distinct radiosensitivity. Following radiation exposure, tumor cells undergo cell cycle arrest, which leads to dynamic redistribution of the cell cycle population. Understanding the mechanisms of cell cycle redistribution is helpful for optimizing radiotherapy intervals, so as to enhance therapeutic efficacy. This paper establishes a two-stage hybrid model combining a Monte Carlo model and a compartment model to characterize the dynamics of radiation-induced tumor cell cycle redistribution. The Monte Carlo component describes cell cycle arrest and subsequent cell cycle evolution of individual tumor cells after irradiation, whereas the compartment model captures the dynamic changes in cell populations across different cell cycle phases. Numerical results demonstrate that the proposed hybrid model outperforms the compartment model in simulating radiation-induced cell cycle redistribution.