DAT阳性联合网织红细胞参数对新生儿ABO溶血病致严重高胆红素血症的研究进展
Research Progress on Direct Antiglobulin Test Positivity Combined with Reticulocyte Parameters in Severe Hyperbilirubinemia Due to ABO Hemolytic Disease of the Newborn
DOI: 10.12677/acm.2026.1693030, PDF,    科研立项经费支持
作者: 马文静, 邓远强：山东第一医科大学(山东省医学科学院)研究生部，山东 济南；张 辉, 李 静*：山东第一医科大学第二附属医院新生儿科，山东 泰安
关键词: 新生儿ABO溶血病；高胆红素血症；直接抗人球蛋白试验；网织红细胞参数；ABO Hemolytic Disease of the Newborn (ABO-HDN)； Hyperbilirubinemia； Direct Antiglobulin Test (DAT)； Reticulocyte Parameters
摘要: 新生儿ABO溶血病(ABO-HDN)是新生儿期引起病理性黄疸的常见病因之一，严重者可遗留后遗症，甚至危及患儿生命。及早识别并准确评估病情严重程度，对减少后遗症、改善预后至关重要。近年来，围绕ABO-HDN病情评估的研究多集中于溶血三项、碳氧血红蛋白(COHb)、血清总胆红素与白蛋白比值(B/A)、以及网织红细胞参数等指标，但尚未形成系统化的严重程度评估体系。本文主要围绕新生儿ABO溶血病相关性研究进展进行综述。
Abstract: ABO hemolytic disease of the newborn (ABO-HDN) is a neonatal emergency caused by maternal–fetal blood group incompatibility. Severe cases may leave permanent sequelae and can even be life-threatening. Early identification and accurate assessment of disease severity are therefore essential to reduce sequelae and improve prognosis. In recent years, studies on HDN severity assessment have largely focused on indicators such as the three hemolysis tests, carboxyhemoglobin (COHb), the bilirubin-to-albumin ratio (B/A), and novel reticulocyte parameters; however, a systematic severity assessment framework has not yet been established. This review summarizes the research progress related to neonatal ABO hemolytic disease.
文章引用：马文静, 张辉, 邓远强, 李静. DAT阳性联合网织红细胞参数对新生儿ABO溶血病致严重高胆红素血症的研究进展[J]. 临床医学进展, 2026, 16(9): 143-151. https://doi.org/10.12677/acm.2026.1693030

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