KLF2、GBP5、DUSP3在结核病中的研究进展
Research Progress of KLF2, GBP5 and DUSP3 in Tuberculosis
DOI: 10.12677/acm.2026.1693049, PDF,    科研立项经费支持
作者: 任 恪*, 刘思谨：延安大学医学院，陕西 延安；李建英#：西安市胸科医院呼吸与危重症医学科，陕西 西安
关键词: 结核病；KLF2；GBP5；DUSP3；Tuberculosis； Krüppel-Like Transcription Factor 2 (KLF2)； Guanylate-Binding Protein 5 (GBP5)； Dual Specificity Phosphatase 3 (DUSP3)
摘要: 结核病是由结核分枝杆菌(Mycobacterium tuberculosis, Mtb)感染的一种慢性呼吸道传染病，给社会经济及公众健康带来了巨大威胁，目前仍是全球传染病的重大挑战，现阶段结核病诊断及疗效监测主要依赖结核分枝杆菌培养及影像学，但其存在明显缺陷，发展基于非痰样本的结核病诊断和疗效监测技术可能是有效的解决方案，近年来发现Krüppel样转录因子2 (Krüppel-Like transcription Factor 2, KLF2)、鸟苷酸结合蛋白5 (Guanylate-Binding Protein 5, GBP5)及双特异性磷酸酶3 (Dual Specificity Phosphatase 3, DUSP3)是与结核病密切相关的宿主转录标志物，其在结核病诊断与疗效评估方面有很大潜力，本文就KLF2、GBP5、DUSP3在结核病发生发展中相关机制、诊断价值、疗效监测等方面进行综述，为结核病的精准防控及新型诊疗策略开发提供参考。
Abstract: Tuberculosis (TB) is a chronic respiratory infectious disease caused by Mycobacterium tuberculosis (Mtb), which poses a severe threat to socioeconomic development and public health and remains a major global challenge in infectious disease control. At present, mycobacterial culture and imaging examinations serve as the primary tools for TB diagnosis and therapeutic response monitoring, yet both methods possess prominent limitations. Developing diagnostic and therapeutic monitoring techniques based on non-sputum specimens may provide an effective alternative strategy. In recent years, Krüppel-like transcription factor 2 (KLF2), guanylate-binding protein 5 (GBP5), and dual specificity phosphatase 3 (DUSP3) have been identified as host transcriptional biomarkers closely associated with tuberculosis, exhibiting great potential for TB diagnosis and therapeutic efficacy evaluation. This review systematically summarizes the research progress regarding KLF2, GBP5 and DUSP3, including their molecular mechanisms underlying TB pathogenesis, diagnostic performance, and capacity for therapeutic response monitoring, so as to offer evidence and insights for precise prevention and control of tuberculosis as well as the development of novel diagnostic and therapeutic regimens.
文章引用：任恪, 刘思谨, 李建英. KLF2、GBP5、DUSP3在结核病中的研究进展[J]. 临床医学进展, 2026, 16(9): 307-314. https://doi.org/10.12677/acm.2026.1693049

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