奥赛利定与舒芬太尼复合丙泊酚用于无痛胃镜检查的对比

Comparison of Oliceridine and Sufentanil Combined with Propofol for Painless Gastrointestinal Endoscopy

摘要: 目的：比较两种阿片类药物复合丙泊酚用于无痛胃肠镜检查的麻醉效果与安全性。方法：择期行无痛胃肠镜检查患者100例，随机分为O组与S组，各50例。记录两组基线资料；监测不同时间点心率(HR)、平均动脉压(MAP)、脉搏血氧饱和度(SpO₂)；记录麻醉起效时间、苏醒时间、丙泊酚总用量；统计术中各类不良事件发生情况。结果：两组患者年龄、性别、BMI、ASA分级及术前生命体征基线资料均衡可比(P > 0.05)。麻醉诱导完成与胃镜置入即刻O组HR低于S组、SpO₂高于S组(P < 0.05)；各时点组间MAP比较差异无统计学意义(P > 0.05)。O组麻醉起效时间显著短于S组(P < 0.001)；两组苏醒时间、丙泊酚总用量差异无统计学意义(P > 0.05)。O组亚临床低氧发生率低于S组(P < 0.05)；呛咳体动、低血压、心动过缓等不良事件发生率两组差异无统计学意义(P > 0.05)。结论：该麻醉方案用于无痛胃肠镜镇静起效更快，可更好维持术中氧合，降低亚临床低氧风险，安全性更优。

Abstract: Objective: To compare the anesthetic efficacy and safety of two opioids combined with propofol for painless gastrointestinal endoscopy. Methods: A total of 100 patients scheduled for elective painless gastrointestinal endoscopy were randomly divided into group O and group S, with 50 patients in each group. Baseline demographic data were collected. Heart rate (HR), mean arterial pressure (MAP) and pulse oxygen saturation (SpO₂) were monitored at different time points. The anesthesia onset time, recovery time and total consumption of propofol were recorded. The incidence of various intraoperative adverse events was statistically analyzed. Results: There were no significant between-group differences in age, gender, body mass index, ASA physical status classification and preoperative vital signs (P > 0.05). At the completion of anesthesia induction and immediately after gastroscope insertion, group O exhibited lower HR and higher SpO₂ than group S (P < 0.05). No intergroup difference in MAP was observed at any time point (P > 0.05). The anesthesia onset time in group O was significantly shorter than that in group S (P < 0.001). Recovery time and total propofol dosage were comparable between the two groups (P > 0.05). The incidence of subclinical hypoxemia was lower in group O (P < 0.05). No significant differences were found in the incidences of cough, body movement, hypotension and bradycardia between the two groups (P > 0.05). Conclusion: This anesthetic regimen achieves faster sedation onset, better intraoperative oxygenation maintenance and reduces the risk of subclinical hypoxemia, conferring superior safety during painless gastrointestinal endoscopy.