IL-6/IL-4、纤维蛋白原对重症急性胰腺炎继发感染性胰腺坏死的预测价值
The Predictive Value of IL-6/IL-4 and Fibrinogen for Infectious Pancreatic Necrosis in Severe Acute Pancreatitis
DOI: 10.12677/acm.2026.1693053, PDF,   
作者: 徐少杰*, 王 琪：安徽医科大学第二附属医院急诊外科，安徽 合肥；高 明：安徽医科大学第二附属医院急诊外科，安徽 合肥；安徽医科大学第二附属医院霍邱医院急诊科，安徽 六安；李宣毅：安徽医科大学第二附属医院放射科，安徽 合肥
关键词: 重症急性胰腺炎；感染性胰腺坏死；白介素-6；白介素-4；MCTSI评分；预测价值；Severe Acute Pancreatitis； Infectious Pancreatic Necrosis； Interleukin-6； Interleukin-4； MCTSI Score； Predictive Value
摘要: 目的：探究血清中IL-6/IL-4、纤维蛋白原(FIB)水平对于重症急性胰腺炎(SAP)继发感染性胰腺坏死(IPN)的预测价值。方法：回顾性分析60例重症急性胰腺炎患者的临床资料，将33例未并发IPN的患者作为非IPN组，27例并发IPN的患者作为IPN组。采用多因素Logistic回归模型分析重症急性胰腺炎患者并发IPN的影响因素，绘制受试者工作特征(ROC)曲线评估IL-6/IL-4、FIB对重症急性胰腺炎患者并发IPN的预测价值，采用Spearman相关法分析IL-6/IL-4、FIB与IPN组患者MCTSI评分的相关性。结果：多因素Logistic回归分析结果显示，IL-6/IL-4、FIB、MCTSI评分是重症急性胰腺炎患者并发IPN的独立危险因素(P < 0.05)。ROC曲线分析结果显示，IL-6/IL-4、FIB单独和联合预测重症急性胰腺炎患者并发IPN的曲线下面积(AUC)分别为0.932、0.823、0.965，联合检测的AUC更大。Spearman相关分析结果显示，IPN组患者的IL-6/IL-4、FIB与MCTSI评分均呈正相关(P < 0.05)。结论：血清IL-6/IL-4、FIB水平对于SAP继发IPN的早期诊断以及病情严重程度评估具有一定的临床意义，并且两项指标进行联合评估的临床价值更高。
Abstract: Objective: To investigate the predictive value of serum IL-6/IL-4 and fibrinogen (FIB) levels for infectious pancreatic necrosis (IPN) secondary to severe acute pancreatitis (SAP). Methods: A retrospective analysis was conducted on the clinical data of 60 patients with severe acute pancreatitis. The 33 patients without IPN were classified as the non-IPN group, and the 27 patients with IPN were classified as the IPN group. A multivariate Logistic regression model was used to analyze the risk factors for IPN in patients with severe acute pancreatitis. Receiver operating characteristic (ROC) curves were plotted to evaluate the predictive value of IL-6/IL-4 and FIB for IPN in patients with severe acute pancreatitis. Spearman’s correlation analysis was used to assess the correlation between IL-6/IL-4, FIB, and the MCTSI scores in patients in the IPN group. Results: Results of multivariate Logistic regression analysis showed that the IL-6/IL-4, FIB, and MCTSI score were independent risk factors for IPN in patients with severe acute pancreatitis (P < 0.05). ROC curve analysis showed that the areas under the curve (AUC) for predicting IPN in patients with severe acute pancreatitis using IL-6/IL-4, FIB, and their combination were 0.932, 0.823, and 0.965, respectively, with the combined test yielding the highest AUC. Spearman’s correlation analysis revealed that IL-6/IL-4, FIB, and the MCTSI score were all positively correlated in patients with IPN (P < 0.05). Conclusion: Serum IL-6/IL-4 and FIB levels have clinical significance for the early diagnosis of IPN secondary to SAP and for assessing disease severity; furthermore, the combined evaluation of these two markers offers even greater clinical value.
文章引用：徐少杰, 王琪, 高明, 李宣毅. IL-6/IL-4、纤维蛋白原对重症急性胰腺炎继发感染性胰腺坏死的预测价值[J]. 临床医学进展, 2026, 16(9): 343-349. https://doi.org/10.12677/acm.2026.1693053

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