肺力咳合剂联合阿奇霉素对支原体肺炎患儿肺功能的影响
Effects of Feilike Mixture Combined with Azithromycin on Pulmonary Function in Children with Mycoplasma Pneumoniae Pneumonia
DOI: 10.12677/tcm.2026.159477, PDF,   
作者: 王艺璁：北京儿童医院黑龙江医院呼吸内科，黑龙江 哈尔滨
关键词: 肺力咳合剂；阿奇霉素；支原体肺炎；肺功能；Feilike Mixture； Azithromycin； Mycoplasma Pneumoniae Pneumonia； Pulmonary Function
摘要: 目的：探讨肺力咳合剂联合阿奇霉素对支原体肺炎患儿肺功能的影响。方法：选取北京儿童医院黑龙江医院2023年2月~2026年3月的70例支原体肺炎患儿，随机分为两组。对照组采取阿奇霉素，观察组采取肺力咳合剂联合阿奇霉素。结果：观察组患儿的有效率高于对照组(P < 0.05)；治疗前，两组的潮气量、呼吸气流量峰值、用力呼气25%流速和呼气时间比较差异无统计学意义(P > 0.05)，治疗后，观察组的潮气量、呼吸气流量峰值、用力呼气25%流速和呼气时间均明显高于对照组(P < 0.05)；治疗前两组血清CRP、PCT水平比较差异无统计学意义(P > 0.05)；治疗后两组CRP、PCT水平均明显下降，且观察组CRP、PCT水平低于对照组(P < 0.05)。结论：肺力咳合剂联合阿奇霉素对支原体肺炎患儿有显著的疗效，能降低炎症指标，提升肺功能。
Abstract: Objective: To investigate the effects of Feilike Mixture combined with azithromycin on pulmonary function in children with Mycoplasma pneumoniae pneumonia. Methods: A total of 70 children diagnosed with Mycoplasma pneumoniae pneumonia admitted to Heilongjiang Hospital of Beijing Children’s Hospital from February 2023 to March 2026 were enrolled and randomly divided into two groups. The control group received azithromycin monotherapy, while the observation group was treated with Feilike Mixture combined with azithromycin. Results: The total clinical effective rate of the observation group was significantly higher than that of the control group (P < 0.05). Before treatment, there were no statistically significant differences between the two groups in tidal volume, peak expiratory flow, forced expiratory flow at 25% of vital capacity (FEF25%), and expiratory time (P > 0.05). After treatment, tidal volume, peak expiratory flow, FEF25%, and expiratory time in the observation group were remarkably superior to those in the control group (P < 0.05). No significant intergroup differences were found in serum C-reactive protein (CRP) and procalcitonin (PCT) levels before treatment (P > 0.05). After intervention, serum CRP and PCT levels decreased markedly in both groups, with lower levels observed in the observation group compared with the control group (P < 0.05). Conclusion: The combination therapy of Feilike Mixture and azithromycin achieves remarkable therapeutic efficacy for children with Mycoplasma pneumoniae pneumonia. It can reduce inflammatory biomarkers and improve pulmonary function.
文章引用：王艺璁. 肺力咳合剂联合阿奇霉素对支原体肺炎患儿肺功能的影响[J]. 中医学, 2026, 15(9): 12-17. https://doi.org/10.12677/tcm.2026.159477

参考文献

[1] 林伟松, 严万德. 甲泼尼龙联合特布他林治疗支原体肺炎患儿疗效及对血清sB7-H3, ESR的影响[J]. 首都食品与医药, 2025, 32(16): 78-81.
[2] 许杰, 李建建. 理肺化痰汤联合孟鲁司特钠治疗支原体肺炎患儿的效果及对血清免疫球蛋白, 中医证候积分的影响[J]. 妇儿健康导刊, 2024, 3(24): 43-46.
[3] 陈娴, 董程. 小儿咳喘灵口服液联合阿奇霉素序贯疗法对肺炎支原体肺炎患儿疗效及炎症反应的影响[J]. 中国妇幼保健, 2024, 39(15): 2866-2869.
[4] 中华中医药学会儿童肺炎联盟. 儿童肺炎支原体肺炎中西医结合诊治专家共识(2017年制定) [J]. 中国实用儿科杂志, 2017, 32(12): 881⁃885.
[5] 刘梦莹, 郑武田, 方辉, 等. 不同年龄难治性支原体肺炎患儿支气管镜治疗后T细胞亚群变化特点及其与疾病转归的关系[J]. 检验医学, 2025, 40(8): 782-788.
[6] 王丽静, 李娟, 孙娜. 小儿肺热咳喘颗粒辅助多西环素治疗肺炎支原体肺炎患儿的疗效及对TRAIL水平及MP-DNA载量的影响[J]. 临床和实验医学杂志, 2026, 25(4): 412-416.
[7] 胡霏, 储振宇, 唐赞. 射麻口服液联合吸入用布地奈德混悬液对肺炎支原体肺炎患儿免疫功能与外周血Toll样受体2信号通路表达水平的影响[J]. 中国药业, 2025, 34(9): 101-105.
[8] 罗慧攀, 李宵宵. 阿奇霉素联合布地奈德治疗支原体肺炎的疗效及对患儿潮气功能, 炎症因子水平的影响[J]. 哈尔滨医药, 2025, 45(5): 84-87.
[9] 刘景, 张景岚, 胡靖, 等. 特布他林联合阿奇霉素序贯疗法对肺炎支原体肺炎患儿TLR4/MyD88/NF-κB通路的影响[J]. 中华医院感染学杂志, 2025, 35(2): 265-269.
[10] 李会, 徐杰, 杨蓓蕾, 等. 微生态制剂联合阿奇霉素治疗肺炎支原体肺炎合并哮喘患儿的效果[J]. 西北药学杂志, 2025, 40(6): 43-49.
[11] 李金霞, 刘慧慧. 热毒宁注射液联合氨溴特罗口服溶液和阿奇霉素注射液治疗支原体肺炎患儿的效果[J]. 中国民康医学, 2024, 36(3): 122-124.
[12] 陈妍, 徐鸽, 俞静云, 等. 阿奇霉素联合小儿豉翘清热颗粒治疗支原体肺炎患儿的效果及对血清炎症细胞因子相关产物表达水平的影响[J]. 中国妇幼保健, 2024, 39(7): 1234-1237.
[13] 冯锴, 李亚男, 刘畅, 等. 中药溻渍联合皮内针治疗肺炎支原体肺炎临床疗效及患儿免疫功能, 炎症因子水平观察[J]. 北京中医药, 2023, 42(12): 1294-1297.
[14] 梁璐, 高伟霞, 曾苑, 等. 肺力咳合剂联合雾化吸入重组人干扰素α2b治疗RSV肺炎患儿的疗效与安全性研究[J]. 海南医学, 2025, 36(17): 2490-2494.
[15] 薛凤莲 谢宁宁. 肺力咳合剂联合氨溴索注射液治疗小儿哮喘合并肺炎的效果及对炎症和肺功能的影响[J]. 基层医学论坛, 2024, 28(26): 42-44.
[16] 刘惠清, 容立炽, 曾华荣. 肺力咳合剂联合哌拉西林钠舒巴坦钠对支原体肺炎合并细菌感染患儿的疗效[J]. 现代医学与健康研究(电子版), 2025, 9(5): 123-125.
[17] 杨珂, 吕云, 乔晓霞. 特布他林雾化吸入联合肺力咳合剂治疗小儿支原体肺炎的效果及对GM-CSF, MPO水平的影响[J]. 临床医学研究与实践, 2024, 9(21): 83-86.
[18] 胡艳, 郝静, 闫慧敏. 儿童肺炎支原体肺炎中西医结合诊疗方案(2023版) [J]. 北京中医药, 2023, 42(11): 1175-1179.