血脂特征谱与骨代谢的相关性研究进展
Research Progress on the Correlation between Serum Lipid Profiles and Bone Metabolism
DOI: 10.12677/acm.2026.1693068, PDF,    科研立项经费支持
作者: 李 宁, 杨家昌:山东第一医科大学第二临床学院,山东 泰安;王 丽:山东第一医科大学第二附属医院,山东 泰安;王 燕*:山东第一医科大学第二临床学院,山东 泰安;山东第一医科大学第二附属医院,山东 泰安
关键词: 血脂;骨代谢;骨矿物质密度;骨质疏松症;载脂蛋白;Serum Lipids; Bone Metabolism; Bone Mineral Density; Osteoporosis; Apolipoproteins
摘要: 骨质疏松症(Osteoporosis)与血脂异常作为两种患病率高、危害性大的代谢性疾病,其共病机制以及交互作用已成为当前研究的热点。本文对血脂特征谱与骨代谢之间的相关性进行综述,尤其关注了非特征性血脂标志物,探讨了血脂异常对骨代谢的影响机制。通过深入分析血脂组分与骨密度、骨折及骨质疏松症的关系,以及降脂药物对骨代谢的影响,旨在为骨质疏松症与心血管代谢性疾病的双重防控提供科学依据。
Abstract: Osteoporosis and dyslipidemia are two highly prevalent metabolic disorders associated with substantial health burdens, and their comorbid mechanisms and interactions have become an important focus of current research. This review summarizes the association between lipid profiles and bone metabolism, with particular emphasis on nontraditional lipid biomarkers, and discusses the potential mechanisms through which dyslipidemia affects bone metabolism. By comprehensively analyzing the relationships of lipid components with bone mineral density, fractures, and osteoporosis, as well as the effects of lipid-lowering drugs on bone metabolism, this review aims to provide a scientific basis for the integrated prevention and management of osteoporosis and cardiometabolic diseases.
文章引用:李宁, 王丽, 王燕, 杨家昌. 血脂特征谱与骨代谢的相关性研究进展[J]. 临床医学进展, 2026, 16(9): 455-463. https://doi.org/10.12677/acm.2026.1693068

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