|
[1]
|
Lavalle, S., Vitello, A., Masiello, E., Dell’Anna, G., Romeo, P., Montana, A., et al. (2025) The Role of Imaging in Inflammatory Bowel Diseases: From Diagnosis to Individualized Therapy. Diagnostics, 15, Article 2457.
https://doi.org/10.3390/diagnostics15192457
|
|
[2]
|
中华医学会消化病学分会炎症性肠病学组, 中国炎症性肠病诊疗质量控制评估中心. 中国溃疡性结肠炎诊治指南(2023年·西安) [J]. 中华炎性肠病杂志(中英文), 2024, 8(1): 33-58.
|
|
[3]
|
Swaminathan, A., Day, A.S., Sparrow, M.P., Peyrin‐Biroulet, L., Siegel, C.A. and Gearry, R.B. (2024) Review Article: Measuring Disease Severity in Inflammatory Bowel Disease—Beyond Treat to Target. Alimentary Pharmacology & Therapeutics, 60, 1176-1199.
https://doi.org/10.1111/apt.18231
|
|
[4]
|
Wine, E., Aloi, M., Van Biervliet, S., Bronsky, J., di Carpi, J.M., Gasparetto, M., et al. (2025) Management of Paediatric Ulcerative Colitis, Part 1: Ambulatory Care—An Updated Evidence‐Based Consensus Guideline from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition and the European Crohn’s and Colitis Organisation. Journal of Pediatric Gastroenterology and Nutrition, 81, 765-815.
https://doi.org/10.1002/jpn3.70097
|
|
[5]
|
Naganuma, M., Nakamura, N., Kunisaki, R., Matsuoka, K., Yamamoto, S., Kawamoto, A., et al. (2024) Medical Treatment Selection and Outcomes for Hospitalized Patients with Severe Ulcerative Colitis as Defined by the Japanese Criteria. Journal of Gastroenterology, 59, 302-314.
https://doi.org/10.1007/s00535-024-02079-x
|
|
[6]
|
Solitano, V., Panaccione, R., Sands, B.E., Wang, Z., Hogan, M., Zou, G., et al. (2025) Responsiveness of Different Disease Activity Indices in Moderate-to-Severe Ulcerative Colitis. Med, 6, Article 100512.
https://doi.org/10.1016/j.medj.2024.09.001
|
|
[7]
|
Kochhar, G.S. and Pal, P. (2025) Endoscopy in Inflammatory Bowel Disease: What Every Endoscopist Should Know. Gastrointestinal Endoscopy, 102, 499-513.
https://doi.org/10.1016/j.gie.2025.04.044
|
|
[8]
|
Uchiyama, K., Takagi, T., Murakami, E. and Naito, Y. (2025) Mucosal Healing of Ulcerative Colitis Based on Endoscopic Diagnosis, Histopathology, and Mucosal Inflammatory Mediators. Inflammatory Intestinal Diseases, 10, 233-245.
https://doi.org/10.1159/000547580
|
|
[9]
|
宋孝美, 于劲, 史立伟, 等. 炎症性肠病内镜评分的临床应用及评价[J]. 中华炎性肠病杂志(中英文), 2023, 7(1): 2-6.
|
|
[10]
|
Kim, K.O. (2022) Endoscopic Activity in Inflammatory Bowel Disease: Clinical Significance and Application in Practice. Clinical Endoscopy, 55, 480-488.
https://doi.org/10.5946/ce.2022.108
|
|
[11]
|
Di Ruscio, M. (2022) How to Assess Endoscopic Disease Activity in Ulcerative Colitis in 2022. Annals of Gastroenterology, 35, 1-9.
https://doi.org/10.20524/aog.2022.0732
|
|
[12]
|
王茸茸, 田玲琳, 霍丽娟. 肠道超声在炎症性肠病中的应用[J]. 中华消化杂志, 2024, 44(4): 283-286.
|
|
[13]
|
Villanacci, V., Maconi, G., Laschi, L. and Bassotti, G. (2025) Diagnosing Ulcerative Colitis: Should We Go Beyond the Surface? Journal of Clinical Medicine, 14, Article 3690.
https://doi.org/10.3390/jcm14113690
|
|
[14]
|
周青杨, 马莉, 唐颢, 等. 免疫检查点抑制剂相关结肠炎的经腹肠道超声特征及其与内镜相关性分析[J]. 中华炎性肠病杂志(中英文), 2025, 9(1): 67-73.
|
|
[15]
|
张福桃, 张雅乐, 孙圆圆, 等. 肠道超声在溃疡性结肠炎诊治中的研究进展[J]. 胃肠病学和肝病学杂志, 2025, 34(3): 448-452.
|
|
[16]
|
黄捷欣, 胡炜, 刘卉, 等. 弥散加权成像在活动期溃疡性结肠炎定量评估中的应用[J]. 分子影像学杂志, 2023, 46(2): 302-306.
|
|
[17]
|
Mirică, R.E., Matură, T.F., Craciun, E. and Pavel, D. (2025) The Importance of Magnetic Resonance Enterography in Monitoring Inflammatory Bowel Disease: A Review of Clinical Significance and Current Challenges. Diagnostics, 15, Article 1540.
https://doi.org/10.3390/diagnostics15121540
|
|
[18]
|
Alyami, A.S. (2024) Imaging of Ulcerative Colitis: The Role of Diffusion-Weighted Magnetic Resonance Imaging. Journal of Clinical Medicine, 13, Article 5204.
https://doi.org/10.3390/jcm13175204
|
|
[19]
|
Lutz, M., Horst, S. and Caldera, F. (2025) Applying Biomarkers in Treat-to-Target Approach for IBD. Current Gastroenterology Reports, 27, Article No. 41.
https://doi.org/10.1007/s11894-025-00991-7
|
|
[20]
|
Ahmed, M., Yuan, P., Lei, J., Tang, Z., Yang, Z., Potempa, L.A., et al. (2025) From Homeostasis to Inflammation to Autoimmunity: The Potential Impact of CRP. Inflammation, 48, 3747-3762.
https://doi.org/10.1007/s10753-025-02303-7
|
|
[21]
|
Vuyyuru, S.K., Alphonsus, L., De Silva, T.A., Solitano, V., Guizzetti, L., Ponich, T., et al. (2025) Day 3 Oxford Criteria Predict Steroid Non-Response for Acute Severe Ulcerative Colitis in the Post Biologic Era. Journal of Crohn’s and Colitis, 19, jjaf131.
https://doi.org/10.1093/ecco-jcc/jjaf131
|
|
[22]
|
Ohta, R., Ryu, Y., Tanaka, K., Sano, C. and Hayashi, H. (2025) C-Reactive Protein in Immune Checkpoint Inhibitor-Associated Colitis: A Scoping Review of Evidence and Knowledge Gaps. Cancer Management and Research, 17, 2631-2641.
https://doi.org/10.2147/cmar.s555819
|
|
[23]
|
Li, P., Xu, Y., Zhou, Y., Sun, R., Gu, Z. and Meng, J. (2025) Fecal Calprotectin Combined with Blood Inflammatory Biomarkers Enhances Diagnostic Evaluation and Supports Mucosal Healing Assessment in Pediatric Crohn’s Disease. Journal of Inflammation Research, 18, 11073-11081.
https://doi.org/10.2147/jir.s535552
|
|
[24]
|
Ishida, N., Takebe, T., Takahashi, K., Asai, Y., Matsuura, T., Yamade, M., et al. (2025) Optimal Positioning of Biomarkers According to Ulcerative Colitis Activity. Scientific Reports, 15, Article No. 19916.
https://doi.org/10.1038/s41598-025-04908-2
|
|
[25]
|
宋玉君, 袁泽宇, 郭静, 等. 病程和病变范围对粪便钙卫蛋白评估溃疡性结肠炎患者内镜下疾病活动度的效能的影响[J]. 国际消化病杂志, 2024, 44(3): 191-195.
|
|
[26]
|
Gallo, A., Covino, M., Baroni, S., Camilli, S., Ibba, F., Andaloro, S., et al. (2024) Diagnostic Accuracy of Fecal Calprotectin in Discriminating Organic-Inflammatory Gastrointestinal Diseases and Functional Gastrointestinal Disorders in Older Patients. Journal of Personalized Medicine, 14, Article 227.
https://doi.org/10.3390/jpm14030227
|
|
[27]
|
Ahmad, R., Habib, S., Siddiqui, S., Zofair, S.F.F., Mustafa, M., Ashraf, H., et al. (2026) Peroxynitrite-Induced Structural Alterations Render Human Fibrinogen More Immunogenic: A Possible Mechanism of Auto-Immune Response That Acts as a Proatherogenic Marker. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 348, Article 127154.
https://doi.org/10.1016/j.saa.2025.127154
|
|
[28]
|
李新艳, 霍江波, 薛建波, 等. NLR、PLR、FIB、D-二聚体在溃疡性结肠炎中的临床价值[J]. 现代消化及介入诊疗, 2022, 27(3): 302-305.
|
|
[29]
|
Yu, Z., Zhao, D., Zhang, Y., Shen, K., Shao, S., Chen, X., et al. (2023) Uncovering Novel Therapeutic Clues for Hypercoagulable Active Ulcerative Colitis: Novel Findings from Old Data. Gastroenterology Report, 12, goae105.
https://doi.org/10.1093/gastro/goae105
|
|
[30]
|
Olatunji, A.O., Sarsour, M., Wuescher, L. and Worth, R. (2025) Platelets and Neutrophil Apoptosis: A New Frontier in Inflammation Resolution. Cureus, 17, e89916.
https://doi.org/10.7759/cureus.89916
|
|
[31]
|
肖静雯, 奥迪, 丛古一, 等. CAR、CBR、PLT与溃疡性结肠炎活动性的相关性研究[J]. 齐齐哈尔医学院学报, 2026, 47(5): 429-434.
|
|
[32]
|
高成超, 程永波. 血小板异常与溃疡性结肠炎关系的研究进展[J]. 山东医药, 2020, 60(35): 109-111.
|
|
[33]
|
Niu, Y., Li, A., Xu, W., Zhang, R., Mei, R., Zhang, L., et al. (2025) Platelet Activation Stimulates Macrophages to Enhance Ulcerative Colitis through PF4/CXCR3 Signaling. International Journal of Molecular Medicine, 55, 1-20.
https://doi.org/10.3892/ijmm.2025.5519
|
|
[34]
|
Zhang, Z., Zhou, X., Zhou, X., Cheng, Z. and Hu, Y. (2025) Role of Platelets and Their Interaction with Immune Cells in Venous Thromboembolism. Seminars in Thrombosis and Hemostasis, 51, 870-878.
https://doi.org/10.1055/s-0044-1789022
|
|
[35]
|
王菁菁, 刘丽改, 谢雯. 白蛋白生理功能再认识[J]. 临床肝胆病杂志, 2025, 41(3): 404-408.
|
|
[36]
|
Cameron, K., Nguyen, A.L., Gibson, D.J., Ward, M.G., Sparrow, M.P. and Gibson, P.R. (2025) Review Article: Albumin and Its Role in Inflammatory Bowel Disease: The Old, the New, and the Future. Journal of Gastroenterology and Hepatology, 40, 808-820.
https://doi.org/10.1111/jgh.16895
|
|
[37]
|
Li Wai Suen, C.F.D., Choy, M.C., Con, D., Cheng, K., Nigro, J., Breheney, K., et al. (2026) Early Infliximab Levels and Clearance Predict Outcomes after Infliximab Rescue in Acute Severe Ulcerative Colitis: Results from Predict-UC. Gastroenterology, 170, 118-131.
https://doi.org/10.1053/j.gastro.2025.07.020
|
|
[38]
|
Li, J., Lyu, H., Yang, H., Li, Y., Tan, B., Wei, M., et al. (2016) Preoperative Corticosteroid Usage and Hypoalbuminemia Increase Occurrence of Short-Term Postoperative Complications in Chinese Patients with Ulcerative Colitis. Chinese Medical Journal, 129, 435-441.
https://doi.org/10.4103/0366-6999.176072
|
|
[39]
|
Zhang, L., Ma, W., Qiu, Z., Kuang, T., Wang, K., Hu, B., et al. (2023) Prognostic Nutritional Index as a Prognostic Biomarker for Gastrointestinal Cancer Patients Treated with Immune Checkpoint Inhibitors. Frontiers in Immunology, 14, Article ID: 1219929.
https://doi.org/10.3389/fimmu.2023.1219929
|
|
[40]
|
Chen, Z., Zeng, L., Cai, W., Song, X., Xu, Q., Xu, J., et al. (2024) Predictive Value of Three Nutritional Indexes for Disease Activity in Patients with Inflammatory Bowel Disease. Annals of Medicine, 57, Article 2443256.
https://doi.org/10.1080/07853890.2024.2443256
|
|
[41]
|
Kato, H., Seishima, R., Nakamura, K., Matsui, S., Shigeta, K., Okabayashi, K., et al. (2023) The Prognostic Nutritional Index Is a Predictive Marker for Postoperative Complications in Patients with Late‐Onset Ulcerative Colitis. World Journal of Surgery, 47, 2867-2875.
https://doi.org/10.1007/s00268-023-07118-x
|
|
[42]
|
Liddicoat, D.R., Kyparissoudis, K., Berzins, S.P., Cole, T.J. and Godfrey, D.I. (2014) The Glucocorticoid Receptor 1A3 Promoter Correlates with High Sensitivity to Glucocorticoid‐Induced Apoptosis in Human Lymphocytes. Immunology & Cell Biology, 92, 825-836.
https://doi.org/10.1038/icb.2014.57
|
|
[43]
|
Singh, A.K., Sachdeva, S., Srivastava, S., Sonika, U., Kumar, A., Sharma, B.C., et al. (2023) Comparing Myelosuppression Frequency in Indian Inflammatory Bowel Disease Patients: A Randomized Trial of Full Dose versus Gradual Escalation of Thiopurines. Cureus, 15, e50969.
https://doi.org/10.7759/cureus.50969
|
|
[44]
|
Su, K., Xiao, S., Wang, M., Wang, K., Fan, Q., Sha, S., et al. (2025) Predictive Value of Albumin to Fibrinogen Ratio and Cally Index for Diagnosis of Ulcerative Colitis and Mucosal Healing after Vedolizumab Treatment. Journal of Inflammation Research, 18, 589-600.
https://doi.org/10.2147/jir.s500600
|
|
[45]
|
Gao, A., Newhart, V., Flory, M., et al. (2025) Pro-Restitutive Bacteroides thetaiotaomicron Reprograms the Transcriptome of Intestinal Epithelial Cells by Modulating the Expression of Genes Essential for Proliferation and Migration. bio-Rxiv.
|
|
[46]
|
Zhang, J., Huang, Y., Trapecar, M., Wright, C., Schneider, K., Kemmitt, J., et al. (2024) An Immune-Competent Human Gut Microphysiological System Enables Inflammation-Modulation by Faecalibacterium Prausnitzii. npj Biofilms and Microbiomes, 10, Article No. 31.
https://doi.org/10.1038/s41522-024-00501-z
|
|
[47]
|
Shah, D., Phan, F., Yu, Z., Choi, J.D.W. and Toh, J.W.T. (2025) Is the Microbiome the Answer to Inflammatory Bowel Disease: Systematic Review. Langenbeck’s Archives of Surgery, 411, Article No. 2.
https://doi.org/10.1007/s00423-025-03897-0
|
|
[48]
|
冯云, 朱军, 潘蓓, 等. 溃疡性结肠炎患者肠道双歧杆菌、肠球菌及真杆菌失调及血清TLR4、MPO表达与疾病活动度的关系[J]. 临床医学, 2023, 43(11): 9-12.
|
|
[49]
|
Earley, H., Lennon, G., Coffey, J.C., Winter, D.C. and O’Connell, P.R. (2021) Colonisation of the Colonic Mucus Gel Layer with Butyrogenic and Hydrogenotropic Bacteria in Health and Ulcerative Colitis. Scientific Reports, 11, Article No. 7262.
https://doi.org/10.1038/s41598-021-86166-6
|
|
[50]
|
Poppe, J., Boesmans, L., Vieira-Silva, S., Deroover, L., Tito, R., Vandeputte, D., et al. (2024) Differential Contributions of the Gut Microbiota and Metabolome to Pathomechanisms in Ulcerative Colitis: An in Vitro Analysis. Gut Microbes, 16, Article 2424913.
https://doi.org/10.1080/19490976.2024.2424913
|
|
[51]
|
Kushkevych, I., Martínková, K., Mráková, L., Giudici, F., Baldi, S., Novak, D., et al. (2024) Comparison of Microbial Communities and the Profile of Sulfate-Reducing Bacteria in Patients with Ulcerative Colitis and Their Association with Bowel Diseases: A Pilot Study. Microbial Cell, 11, 79-89.
https://doi.org/10.15698/mic2024.03.817
|
|
[52]
|
Lee, J.W.J., Plichta, D., Hogstrom, L., Borren, N.Z., Lau, H., Gregory, S.M., et al. (2021) Multi-Omics Reveal Microbial Determinants Impacting Responses to Biologic Therapies in Inflammatory Bowel Disease. Cell Host & Microbe, 29, 1294-1304.e4.
https://doi.org/10.1016/j.chom.2021.06.019
|
|
[53]
|
Liu, X., Li, Y., Wu, K., Shi, Y. and Chen, M. (2021) Fecal Microbiota Transplantation as Therapy for Treatment of Active Ulcerative Colitis: A Systematic Review and Meta-Analysis. Gastroenterology Research and Practice, 2021, 1-13.
https://doi.org/10.1155/2021/6612970
|
|
[54]
|
刘续, 严春日. 肠道菌群与代谢性疾病研究进展[J]. 延边大学医学学报, 2026, 49(5): 13-17.
|
|
[55]
|
Zhao, C. and Lin, S. (2025) Panoptosis in Intestinal Epithelium: Its Significance in Inflammatory Bowel Disease and a Potential Novel Therapeutic Target for Natural Products. Frontiers in Immunology, 15, Article ID: 1507065.
https://doi.org/10.3389/fimmu.2024.1507065
|
|
[56]
|
Buldukoglu, O.C., Ocal, S., Akca, S., Atar, G.E., Kaya, B., Isik, M.D., et al. (2025) A Novel Inflammatory Biomarker in Assessing Disease Activity in Ulcerative Colitis: Gasdermin D. BMC Gastroenterology, 25, Article No. 418.
https://doi.org/10.1186/s12876-025-04009-4
|
|
[57]
|
Rong, S.J., Yang, C.L., Wang, F.X., Sun, F., Luo, J.H., Yue, T.T., et al. (2022) The Essential Role of Foxo1 in the Regulation of Macrophage Function. BioMed Research International, 2022, Article ID: 1068962.
https://doi.org/10.1155/2022/1068962
|
|
[58]
|
Cao, W., Cheng, Y., Wang, X., Wang, L., Li, R., Pei, S., et al. (2026) Alkaline Sphingomyelinase (ENPP7) Attenuates DSS-Induced Colitis by Modulating FOXO1-Mediated Antioxidative Stress Responses. BMC Gastroenterology, 26, Article No. 315.
https://doi.org/10.1186/s12876-026-04832-3
|
|
[59]
|
侯宇格, 段花玲, 魏小娟, 等. 溃疡性结肠炎患者血清叉头框蛋白O1和高迁移率族蛋白A1与疾病活动度及短期预后的关系[J]. 中华实用诊断与治疗杂志, 2025, 39(1): 50-55.
|
|
[60]
|
Jiang, N., Liu, Z., Wang, H., Zhang, L., Li, M., Li, G., et al. (2024) Alterations in Metabolome and Microbiome: New Clues on Cathelicidin-Related Antimicrobial Peptide Alleviates Acute Ulcerative Colitis. Frontiers in Microbiology, 15, Article ID: 1306068.
https://doi.org/10.3389/fmicb.2024.1306068
|
|
[61]
|
Tratenšek, A., Locatelli, I., Grabnar, I., Drobne, D. and Vovk, T. (2024) Oxidative Stress-Related Biomarkers as Promising Indicators of Inflammatory Bowel Disease Activity: A Systematic Review and Meta-Analysis. Redox Biology, 77, Article 103380.
https://doi.org/10.1016/j.redox.2024.103380
|
|
[62]
|
Wang, X., Jiang, N., Yin, W. and Cui, X. (2025) MicroRNAs as Multifaceted Regulators and Therapeutic Targets in Ulcerative Colitis. Frontiers in Immunology, 16, Article ID: 1697059.
https://doi.org/10.3389/fimmu.2025.1697059
|
|
[63]
|
Vestergaard, M.V., Allin, K.H., Nøhr, A.K., Torresano Lominchar, J.V., Christensen, H.S., Krarup, H., et al. (2026) Genetic Risk of Inflammatory Bowel Disease Is Associated with Disease Course Severity. Gastroenterology, 170, 721-734.
https://doi.org/10.1053/j.gastro.2025.09.018
|
|
[64]
|
Vestergaard, M.V., Nøhr, A.K., Allin, K.H., Krarup, H., Larsen, L., Sazonovs, A., et al. (2024) HLA-DRB1*01:03 and Severe Ulcerative Colitis. JAMA, 332, 1941-1943.
https://doi.org/10.1001/jama.2024.20429
|
|
[65]
|
Minea, H., Singeap, A., Minea, M., Juncu, S., Muzica, C., Sfarti, C.V., et al. (2024) The Contribution of Genetic and Epigenetic Factors: An Emerging Concept in the Assessment and Prognosis of Inflammatory Bowel Diseases. International Journal of Molecular Sciences, 25, Article 8420.
https://doi.org/10.3390/ijms25158420
|
|
[66]
|
Urbančič, D., Pasha, F., Šmid, A. and Mlinarič-Raščan, I. (2024) Personalization of Thiopurine Therapy: Current Recommendations and Future Perspectives. Acta Pharmaceutica, 74, 355-381.
https://doi.org/10.2478/acph-2024-0030
|
|
[67]
|
Kennedy, A.M., Griffiths, A.M., Muise, A.M., Walters, T.D., Ricciuto, A., Huynh, H.Q., et al. (2024) Landscape of TPMT and NUDT15 Pharmacogenetic Variation in a Cohort of Canadian Pediatric Inflammatory Bowel Disease Patients. Inflammatory Bowel Diseases, 30, 2418-2427.
https://doi.org/10.1093/ibd/izae109
|
|
[68]
|
Kapel, N., Ouni, H., Benahmed, N.A. and Barbot-Trystram, L. (2023) Fecal Calprotectin for the Diagnosis and Management of Inflammatory Bowel Diseases. Clinical and Translational Gastroenterology, 14, e00617.
https://doi.org/10.14309/ctg.0000000000000617
|
|
[69]
|
DʼHaens, G., Ferrante, M., Vermeire, S., Baert, F., Noman, M., Moortgat, L., et al. (2012) Fecal Calprotectin Is a Surrogate Marker for Endoscopic Lesions in Inflammatory Bowel Disease. Inflammatory Bowel Diseases, 18, 2218-2224.
https://doi.org/10.1002/ibd.22917
|
|
[70]
|
Ai, J., Duan, X., Wang, R. and Chen, P. (2025) Use of Cellular Free Nucleic Acids for Diagnosis and Treatment of Inflammatory Bowel Disease. Chinese Medical Journal, 139, 1405-1407.
https://doi.org/10.1097/cm9.0000000000003547
|