2D-STI在VEGF抑制剂所致肺癌患者心脏毒性防治中的研究进展

Research Progress of 2D-STI in the Prevention and Treatment of Cardiotoxicity in Lung Cancer Patients Caused by VEGF Inhibitors

摘要: 肺癌已经连续12年位居我国恶性肿瘤发病、死亡双第一，其中非小细胞肺癌占据绝大多数。目前临床针对非小细胞肺癌主要应用VEGF抑制剂进行靶向治疗，VEGF抑制剂是非小细胞肺癌一线抗血管生成药物，但有研究证实，该药物在治疗过程中对患者心脏产生了严重的心脏毒性作用，且早期难以被常规超声心动图发现。二维斑点追踪成像(2D-STI)可定量分析心肌整体及局部应变功能，能够敏感捕捉靶向药物所致微小心肌形变异常，是目前肿瘤心脏病学的热门监测技术，对肺癌患者亚临床心脏病变的早发现、早诊断、早治疗有重要意义。

Abstract: Lung cancer has ranked first in both incidence and mortality of malignant tumors in China for 12 consecutive years, among which non-small cell lung cancer accounts for the vast majority. Currently, VEGF inhibitors are the main targeted therapy for non-small cell lung cancer in clinical practice, and they are first-line anti-angiogenic agents for non-small cell lung cancer. However, existing studies have confirmed that this drug induces severe cardiotoxicity on patients’ hearts during treatment, and such toxicity can hardly be detected by conventional echocardiography at the early stage. Two-dimensional speckle tracking imaging (2D-STI) can quantitatively analyze the global and regional myocardial strain function, and sensitively capture subtle abnormal myocardial deformation induced by targeted drugs. It is currently a popular monitoring technique in cardio-oncology, and is of great significance for the early detection, early diagnosis and early treatment of subclinical cardiac lesions in lung cancer patients.