青藤碱在结肠癌中的研究进展——从分子机制到临床转化新策略
Research Progress of Sinomenine in Colon Cancer—From Molecular Mechanisms to Novel Strategies for Clinical Translation
DOI: 10.12677/acm.2026.1693148, PDF,    科研立项经费支持
作者: 沈乾龙, 刘秋霞*：绍兴大学医学院，浙江 绍兴；绍兴大学附属第一医院肿瘤内科，浙江 绍兴
关键词: 青藤碱；结肠癌；抗肿瘤机制；联合治疗；化学预防；Sinomenine； Colon Cancer； Anti-Tumor Mechanisms； Combination Therapy； Chemical Prevention
摘要: 青藤碱是一种从中药青风藤中提取的生物碱，具有抗炎、抗风湿及免疫调节等作用，并在临床前研究中展现出良好的抗肿瘤潜力。本文系统综述了青藤碱可以通过多靶点途径发挥协同抗肿瘤效应治疗结肠癌的作用机制：调控PI3K/Akt/mTOR通路、诱导细胞周期阻滞以抑制肿瘤细胞增殖；调控ERK/MAPK信号通路及代谢重编程以促进肿瘤细胞凋亡；抑制慢性炎症并改善肿瘤微环境；以及调节肠道菌群–免疫轴等。文章还探讨了青藤碱在未来临床应用中的优势与前景，如在联合用药中减轻化疗或靶向药物的耐药性，以及通过化学预防阻断“结肠炎癌转化”进程等。此外，本文分析了当前青藤碱药物研发与临床转化中面临的挑战，并提出相应对策，以期青藤碱能尽早实现临床转化并能为结肠癌的防治提供一种新的选择。
Abstract: Sinomenine is an alkaloid extracted from the traditional Chinese medicine Sinomenii caulis. It has anti-inflammatory, anti-rheumatic and immunomodulatory effects, and has shown good anti-tumor potential in preclinical studies. This article systematically reviews the mechanism by which sinophylline can exert a synergistic anti-tumor effect in the treatment of colon cancer through multiple target pathways: Regulating the PI3K/Akt/mTOR pathway and inducing cell cycle arrest to inhibit tumor cell proliferation; regulating the ERK/MAPK signaling pathway and metabolic reprogramming to promote tumor cell apoptosis; suppressing chronic inflammation and improving the tumor microenvironment; and modulating the gut microbiota-immune axis, among others. The article also explores the advantages and prospects of sinomenine in future clinical applications, such as reducing the resistance to chemotherapy or targeted drugs in combination therapy, and blocking the process of “colitis cancer transformation” through chemopprophylaxis. In addition, this article analyzes the challenges currently faced in the research and development and clinical transformation of sinomenine drugs, and proposes corresponding countermeasures, with the aim of achieving clinical transformation of sinomenine as soon as possible and providing a new option for the prevention and treatment of colon cancer.
文章引用：沈乾龙, 刘秋霞. 青藤碱在结肠癌中的研究进展——从分子机制到临床转化新策略[J]. 临床医学进展, 2026, 16(9): 1147-1156. https://doi.org/10.12677/acm.2026.1693148

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