基于“抑木扶土”法探讨经典名方化肝煎治疗消化系统疾病的研究进展

Discussing the Research Progress of the Classic Formula Huagan Decoction in Treating Digestive System Diseases from the Perspective of the “Yimu Futu” Method

摘要: 消化系统疾病多具有病程迁延、进展缓慢、反复发作的特点，长期影响患者生活质量并带来持续诊疗压力。化肝煎源自明代医家张介宾《景岳全书》，是治疗肝郁化火证的代表方，其通过其靶点、多通路、多成分的协同作用在治疗消化系统疾病，如胃食管反流病、消化性溃疡、肝损伤等消化系统疾病中展现明显优势。本文基于“抑木扶土”理论对化肝煎的组方配伍进行分析，并对其在消化系统疾病的应用进行了综述，展现了经典名方的“异病同治”优势，阐明其治疗消化系统疾病的潜在作用机制。然而，当前对化肝煎的研究仍存在不足，其全方协同药理机制与制剂研发亦有待深化，未来仍需借助多学科技术开展深入探索。

Abstract: Digestive system diseases are often characterized by prolonged course, slow progression, and recurrent attacks, which affect the quality of life of patients for a long time and bring continuous diagnosis and treatment pressure. Huagan decoction is derived from the Ming Dynasty physician Zhang Jiebin’s “Jingyue Quanshu”, which is a representative prescription for the treatment of liver stagnation and fire syndrome, and it shows obvious advantages in the treatment of digestive system diseases, such as gastroesophageal reflux disease, peptic ulcer, liver injury and other digestive system diseases through its target, multi-pathway and multi-component synergistic effect. Based on the theory of “Yimu Futu”, this paper analyzes the compatibility of the formula of Huagan Decoction, reviews its application in digestive system diseases, shows the advantages of “treating different diseases together” of classic prescriptions, and clarifies its potential mechanism of action in the treatment of digestive system diseases. However, the current research on Huagan Decoction is still insufficient, and the research and development of its synergistic pharmacological mechanism and preparation of the whole prescription need to be deepened, and in-depth exploration is still needed with the help of multidisciplinary technology in the future.