住院患者脓毒症管理的急诊护理实践进展
Progress in Emergency Nursing Practice for the Management of Hospitalized Patients with Sepsis
摘要: 脓毒症作为急诊科最常见、病情进展最快的急危重症,也是全球致死率最高的疾病之一,其核心为感染诱发宿主反应失调导致的危及生命的器官功能障碍。急诊科作为脓毒症早期识别、复苏与分级处置的第一环节,急诊护理决策十分重要。本文基于最新内科学年鉴(Annals of Internal Medicine, AIM)住院患者脓毒症管理权威综述,结合拯救脓毒症运动(Surviving Sepsis Campaign, SSC)指南与急诊护理实践,从急诊护理角度出发将脓毒症急诊识别、监测评估、核心救治、并发症防治及延续性护理等方面进行全面综述,为构建标准化、规范化的急诊脓毒症护理体系提供循证学依据。
Abstract: Sepsis is one of the most common and rapidly‑progressing critical emergencies in the emergency department, as well as a disease with the highest mortality worldwide. Its core pathogenesis is life‑threatening organ dysfunction caused by dysregulated host responses to infection. The emergency department serves as the frontline for early recognition, resuscitation and stratified management of sepsis, where emergency nursing decision‑making plays a vital role. Based on the authoritative review on sepsis management among hospitalized patients published in Annals of Internal Medicine (AIM), combined with the Surviving Sepsis Campaign (SSC) guidelines and clinical emergency nursing practice, this paper comprehensively reviews emergency‑department‑based sepsis care from the perspectives of early identification, monitoring and assessment, core treatment, complication prevention and management, and continuous nursing. It aims to provide evidence‑based references for establishing a standardized and normative emergency nursing system for sepsis.
文章引用:杨燕, 邵博阳, 冉霖玲, 向可佳. 住院患者脓毒症管理的急诊护理实践进展[J]. 临床医学进展, 2026, 16(9): 1177-1184. https://doi.org/10.12677/acm.2026.1693152

参考文献

[1] Palakshappa, J.A. and Taylor, S.P. (2025) Management of Sepsis in Hospitalized Patients. Annals of Internal Medicine, 178, ITC161-ITC176.
https://doi.org/10.7326/annals-25-02685
[2] Delaney, A., Borges-Sa, M., Chew, M.S., De Waele, J.J., Dye, J., Khanna, A.K., et al. (2026) Current Standard of Care for Septic Shock. Intensive Care Medicine, 52, 89-103.
https://doi.org/10.1007/s00134-025-08211-6
[3] Sanchez E., C., Taha, A., Tolba, Y., Hernandez, G. and Pinsky, M.R. (2025) Assessment of Tissue Perfusion Pressure in Patients with Septic Shock: Beyond Mean Arterial Pressure. Critical Care Medicine, 53, e2305-e2317.
https://doi.org/10.1097/ccm.0000000000006805
[4] Azoulay, E., Zafrani, L., Nates, J., Maillard, A., Chean, D., Ferreyro, B., et al. (2025) Advances in the Critical Care Management for Patients with Hematological Malignancies. Blood Reviews, 74, Article ID: 101306.
https://doi.org/10.1016/j.blre.2025.101306
[5] Deinhardt-Emmer, S., Chousterman, B.G., Schefold, J.C., Flohé, S.B., Skirecki, T., Kox, M., et al. (2025) Sepsis in Patients Who Are Immunocompromised: Diagnostic Challenges and Future Therapies. The Lancet Respiratory Medicine, 13, 623-637.
https://doi.org/10.1016/s2213-2600(25)00124-9
[6] Tan, R., Ge, C., Li, Z., Yan, Y., Guo, H., Song, W., et al. (2025) Early Prediction of Mortality Risk in Acute Respiratory Distress Syndrome: Systematic Review and Meta-Analysis. Journal of Medical Internet Research, 27, e70537.
https://doi.org/10.2196/70537
[7] Al-Juhani, A., Desoky, R., Iskander, Z., Alshehri, K.T., Alshehri, A.A., Almuhaimid, A., et al. (2025) Advances in Data-Driven Early Warning Systems for Sepsis Recognition and Intervention in Emergency Care: A Systematic Review of Diagnostic Performance and Clinical Outcomes. Cureus, 17, e89882.
https://doi.org/10.7759/cureus.89882
[8] Harrison, C.H., Tupper, P., Gerry, S., Michael, V., Bedford, J.P., Smith, C., et al. (2025) Oxygen Therapy in Early Warning Scores: A Systematic Review and Meta-Analysis. Thorax, 80, 693-701.
https://doi.org/10.1136/thorax-2024-222663
[9] Goulas, K., Müller, M. and Exadaktylos, A.K. (2025) Assessing Monoclonal and Polyclonal Antibodies in Sepsis and Septic Shock: A Systematic Review of Efficacy and Safety. International Journal of Molecular Sciences, 26, Article No. 8859.
https://doi.org/10.3390/ijms26188859
[10] Monnet, X., Messina, A., Greco, M., Bakker, J., Aissaoui, N., Cecconi, M., et al. (2025) ESICM Guidelines on Circulatory Shock and Hemodynamic Monitoring 2025. Intensive Care Medicine, 51, 1971-2012.
https://doi.org/10.1007/s00134-025-08137-z
[11] Miller, A., Wilkinson, J. and Kasal, J. (2025) Diagnosis of Shock States. Critical Care Clinics, 41, 397-428.
https://doi.org/10.1016/j.ccc.2025.03.001
[12] Scott, L.J., Jackson, J., Dawson, S., Knight, T. and Savović, J. (2026) Does the Use of National Early Warning Scores (NEWS or NEWS2) in Healthcare Settings Improve Patient Outcomes: A Systematic Review. Systematic Reviews, 15, Article No. 73.
https://doi.org/10.1186/s13643-026-03088-y
[13] Kotta, P.A., Uppalapati, L., Elango, M., Triska, J. and Senussi, M.H. (2026) Resuscitative Mean Arterial Pressure Targets in Cardiovascular Disease: A Narrative Review of Clinical Outcomes. Cardiovascular Drugs and Therapy, 40, 757-777.
https://doi.org/10.1007/s10557-025-07738-6
[14] Leone, M., Myatra, S.N., Dugar, S., Wieruszewski, P.M., Russell, L., Evans, L., et al. (2026) Clinical Criteria for the Definition of Refractory Septic Shock: A Joint Delphi Consensus from the Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM). Critical Care Medicine, 54, 1073-1091.
https://doi.org/10.1097/ccm.0000000000007124
[15] Giannakoulas, G., Farmakis, I.T., Hobohm, L., Verbrugge, F.H., Tedford, R.J. and Sanz, J. (2025) Acute Right Ventricular Failure: Pathophysiology, Aetiology, Assessment, and Management. European Heart Journal, 46, 2520-2535.
https://doi.org/10.1093/eurheartj/ehaf215
[16] Cerda, J., Kashani, K., Ostermann, M., Basu, R.K., Bell, S., Cantaluppi, V., et al. (2026) The Global Epidemiology of Acute Kidney Injury: Challenges and Opportunities. Nature Reviews Nephrology, 22, 179-198.
https://doi.org/10.1038/s41581-025-01030-4
[17] Etienne, S., Hoheisel, A., Agarwal, P., Kiefer, S., Wehrle, J., Renz, H., et al. (2025) Quantitative Computed Tomography and Predictive Modelling for COPD Exacerbations. European Respiratory Review, 34, Article ID: 250097.
https://doi.org/10.1183/16000617.0097-2025
[18] Zhang, J., Wu, D., Zeng, F., Gu, H., Li, C., Cata, J.P., et al. (2025) Lactate Metabolic Reprogramming and Histone Lactylation Modification in Sepsis. International Journal of Biological Sciences, 21, 5034-5055.
https://doi.org/10.7150/ijbs.116088
[19] Li, X.-Y., Chen, W.-S., Qu, Z.-K., Chen, J.-G., Li, L., Li, S.-N., et al. (2025) Early Use of Albumin May Increase the Risk of Sepsis-Associated Acute Kidney Injury in Sepsis Patients: A Target Trial Emulation. Military Medical Research, 12, Article No. 51.
https://doi.org/10.1186/s40779-025-00641-z
[20] Pecci, J., van Dyk, N., Myer, G.D. and Sañudo, B. (2026) Return-to-Play Criteria Following Lower Limb Muscle Injuries in Soccer: A Systematic Review with Evidence Synthesis. Sports Medicine, 56, 1433-1465.
https://doi.org/10.1007/s40279-026-02404-9
[21] Yang, W., Cao, Y., Li, J., Zhang, X., Liu, X., Tian, Y., et al. (2025) Pathogenesis and Treatment Strategies of Sepsis-Induced Myocardial Injury: Modern and Traditional Medical Perspectives. International Journal of Biological Sciences, 21, 3478-3504.
https://doi.org/10.7150/ijbs.111288
[22] Tong, S.Y.C., Fowler, V.G., Skalla, L. and Holland, T.L. (2025) Management of Staphylococcus aureus Bacteremia: A Review. JAMA, 334, 798-808.
https://doi.org/10.1001/jama.2025.4288
[23] Thomas, A., Almsallaty, N., Chalati, T., Boateng, J., Buanz, A. and Totea, A.M. (2025) Role of Methicillin-Resistant Staphylococcus aureus in Cutaneous Infections: Current Treatments and Therapeutic Approaches for Future Advancement. International Journal of Pharmaceutics, 684, Article ID: 126030.
https://doi.org/10.1016/j.ijpharm.2025.126030
[24] Braun, C., Graham, F., Fleischer, D.M., Molloy, J., Bégin, P. and Eigenmann, P. (2025) The Evolution of IgE-Based Allergy Testing in Atopic Dermatitis: Where Do We Stand? The Journal of Allergy and Clinical Immunology: In Practice, 13, 1879-1886.
https://doi.org/10.1016/j.jaip.2025.05.013
[25] Zhu, L.X., Chen, Y., Chen, X.F., Sheng, N. and Feng, P.F. (2025) Systematic Review and Meta-Analysis of the Clinical Efficacy of Octreotide in Combination with Ulinastatin in the Treatment of Acute Pancreatitis. Drugs in R&D, 25, 195-207.
https://doi.org/10.1007/s40268-025-00518-5
[26] Jones, B.E., Ramirez, J.A., Oren, E., Soni, N.J., Sullivan, L.R., Restrepo, M.I., et al. (2026) Diagnosis and Management of Community-Acquired Pneumonia. an Official American Thoracic Society Clinical Practice Guideline. American Journal of Respiratory and Critical Care Medicine, 212, 24-44.
https://doi.org/10.1164/rccm.202507-1692st
[27] Shi, R., Braïk, R., Monnet, X., Gu, W., Ospina-Tascon, G., Permpikul, C., et al. (2025) Early Norepinephrine for Patients with Septic Shock: An Updated Systematic Review and Meta-Analysis with Trial Sequential Analysis. Critical Care, 29, Article No. 182.
https://doi.org/10.1186/s13054-025-05400-z
[28] Lajoye, Q., Orieux, A., Boyer, A., Prevel, R. and Jozwiak, M. (2025) Vasopressin and Its Analogues in Patients with Septic Shock: Holy Grail or Unfulfilled Promise? Critical Care, 29, Article No. 333.
https://doi.org/10.1186/s13054-025-05540-2
[29] Guo, L., Wang, Q. and Li, X. (2025) The Role of SR-BI in Sepsis: Leveraging Mechanistic Insights to Advance Precision Steroid Therapy. Frontiers in Immunology, 16, Article ID: 1643395.
https://doi.org/10.3389/fimmu.2025.1643395
[30] Li, J., Zhang, Y., Jiang, F., Shi, X., Tu, M., Liu, Z., et al. (2026) Precision Medicine in Sepsis: Reappraising Glucocorticoid Therapy through the Lens of Molecular Endotypes. Inflammation Research, 75, Article No. 38.
https://doi.org/10.1007/s00011-025-02173-7
[31] Cardona, Z., Friedman, J.G., Kamal, N., Oakes, D.J., Wallia, A., Aleppo, G., et al. (2025) Developing a Protocol for Management of Euglycemic Diabetic Ketoacidosis. Current Diabetes Reports, 25, Article No. 48.
https://doi.org/10.1007/s11892-025-01604-3
[32] Thammakosol, K., Vongtangton, P., Numthavaj, P., Auttara‐atthakorn, A. and Sriphrapradang, C. (2026) Early Subcutaneous Basal Insulin with Intravenous Insulin Infusion for Diabetic Ketoacidosis Management: A Systematic Review and Meta‐Analysis of Randomised Controlled Trials. Diabetes, Obesity and Metabolism, 28, 1036-1048.
https://doi.org/10.1111/dom.70276
[33] Manley, G.T., Dams-O’Connor, K., Alosco, M.L., Awwad, H.O., Bazarian, J.J., Bragge, P., et al. (2025) A New Characterisation of Acute Traumatic Brain Injury: The NIH-NINDS TBI Classification and Nomenclature Initiative. The Lancet Neurology, 24, 512-523.
[34] Juarez-Martinez, E.L., Araia, A., Prasad, D., Dhar, S., Nandoliya, K., Sherrington, I.G., et al. (2025) Five-Decade Prevalence of Delirium in Pneumonia, Risk Factors and Associated Mortality: A Systematic Review and Meta-Analysis. European Respiratory Review, 34, Article ID: 250111.
https://doi.org/10.1183/16000617.0111-2025
[35] Tang, A.B., Lewsey, S.C., Yancy, C.W., Heidenreich, P.A., Greene, S.J., Allen, L.A., et al. (2025) Get with the Guidelines-Heart Failure: Twenty Years in Review, Lessons Learned, and the Road Ahead. Circulation: Heart Failure, 18, e012936.
https://doi.org/10.1161/circheartfailure.125.012936
[36] Yahya, F.B., Van Abel, A.L., Brakke, B.D., Palraj, R., Szymanski, L.M., Chapman, M.L., et al. (2025) Maternal Sepsis Review and Update. Mayo Clinic Proceedings, 100, 1212-1230.
https://doi.org/10.1016/j.mayocp.2025.03.024
[37] Munroe, E.S., Spicer, A., Castellvi-Font, A., Zalucky, A., Dianti, J., Graham Linck, E., et al. (2025) Evidence-Based Personalised Medicine in Critical Care: A Framework for Quantifying and Applying Individualised Treatment Effects in Patients Who Are Critically Ill. The Lancet Respiratory Medicine, 13, 556-568.
https://doi.org/10.1016/s2213-2600(25)00054-2
[38] Marra, A., Smith, R.J., Pandharipande, P.P. and Hayhurst, C.J. (2025) Optimal Sedation in Ventilated Patients with Sepsis and Septic Shock. Critical Care Clinics, 41, 775-790.
https://doi.org/10.1016/j.ccc.2025.05.004
[39] Garcia Valencia, O.A., Suppadungsuk, S., Thongprayoon, C., Ho, Y., Siranart, N., Wathanavasin, W., et al. (2025) Health Insurance and Kidney Transplantation Outcomes in the United States: A Systematic Review and AI-Driven Analysis of Disparities in Access and Survival. Renal Failure, 47, Article ID: 2513007.
https://doi.org/10.1080/0886022x.2025.2513007
[40] Gainza, P., Bunker, R.D., Townson, S.A. and Castle, J.C. (2025) Machine Learning to Predict De Novo Protein-Protein Interactions. Trends in Biotechnology, 43, 3056-3070.
https://doi.org/10.1016/j.tibtech.2025.04.013
[41] Shanmugam, D., Agrawal, M., Movva, R., Chen, I.Y., Ghassemi, M., Jacobs, M., et al. (2025) Generative Artificial Intelligence in Medicine. Annual Review of Biomedical Data Science, 8, 199-226.
https://doi.org/10.1146/annurev-biodatasci-103123-095332